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Pharmaceutical Inhalation Aerosol Technology

Overview

This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging ...

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Overview

This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.

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Product Details

Table of Contents

Foreword
Foreword to the First Edition
Preface
Contributors
1 Physiology of the Airways 1
2 Pharmacology of Therapeutic Aerosols 31
3 Targeting by Deposition 65
4 Drug Targeting to the Lung: Chemical and Biochemical Considerations 89
5 Lung Deposition Simulation 155
6 Practical Aspects of Imaging Techniques Employed to Study Aerosol Deposition and Clearance 171
7 Pharmacokinetics and Pharmacodynamics of Drugs Delivered to the Lungs 215
8 Theoretical Principles and Devices Used to Generate Aerosols for Research 253
9 The Design and Development of Inhalation Drug Delivery Systems 279
10 Aerosol-Filling Equipment for the Preparation of Pressurized-Pack Pharmaceutical Formulations 311
11 Methods of Aerosol Particle Size Characterization 345
12 Summary of Common Approaches to Pharmaceutical Aerosol Administration 385
13 Therapeutic Aerosols: An Overview from a Clinical Perspective 423
14 Aerosolized Pentamidine for Treatment and Prophylaxis of Pneumocystis carinii Pneumonia in Patients with Acquired Immunodeficiency Syndrome 459
15 The Application of Aerosolized Antimicrobial Therapies in Lung Infections 473
16 Gene Delivery to the Lung 489
17 Recent Advances Related to the Systemic Delivery of Therapeutic Molecules by Inhalation 541
18 Modulated Drug Therapy with Inhalation Aerosols: Revisited 551
19 Pulmonary Delivery Technology: Recent Advances and Potential for the New Millennium 571
Index 593
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