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Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future.
Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.
"This book presents detailed discussions of the published process chemistry of the ten top-selling small molecule drugs in the US in 2007, information which is usually carefully protected by the current and future manufacturers." (TMCnet.com, 17 March 2011)
Chapter 2: Actos® (pioglitazone hydrochloride).
Chapter 3: Lexapro® (escitalopram oxalate).
Chapter 4: Efferox XR® (venlafaxine hydrochloride).
Chapter 5: Seroquel® (quetiapine hemifumarate).
Chapter 6: Singulair® (montelukast sodium).
Chapter 7: Prevacid® (lansoprazole).
Chapter 8: Advair Diskus® (salmeterol xinafoate).
Chapter 9: Lipitor® (atorvastatin calcium).
Overview
Providing insights about ...