Pharmaceutical Profiling in Drug Discovery for Lead Selection / Edition 1

Pharmaceutical Profiling in Drug Discovery for Lead Selection / Edition 1

by Ronald Borchardt
     
 

ISBN-10: 0971176795

ISBN-13: 9780971176799

Pub. Date: 06/28/2004

Publisher: American Association of Pharmaceutical Scientists

This volume focuses on how to increase the efficiency of drug discovery and development. It is written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences. The volume details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties to select

Overview

This volume focuses on how to increase the efficiency of drug discovery and development. It is written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences. The volume details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties to select and improve potential drug candidates.

Product Details

ISBN-13:
9780971176799
Publisher:
American Association of Pharmaceutical Scientists
Publication date:
06/28/2004
Series:
Biotechnology: Pharmaceutical Aspects Series, #1
Edition description:
2004
Pages:
482
Product dimensions:
7.01(w) x 10.00(h) x 0.06(d)

Related Subjects

Table of Contents

Absorption Prediction.- Predicting Molecular Physical Properties.- In Silico Transporter Modeling and Its Application in Drug Discovery.- Models for Cyhrome P450-Mediated Metabolism.- Future of In Silico Methods in Toxicology.- Solubility in Water and DMSO: Issues and Potential Solutions.- Measurements of Lipophilicity and Acid/Base Character Using HPLC Methods.- How Do We Study Oxidative Chemical Stability in Discovery? Some Ideas, Trials, and Outcomes.- Physiochemical Methods for Estimating Permeability and Related Properties.- Cultured Epithelial Cell Assays Used to Estimate Intestinal Absorption Potential.- In Vitro Cell-based Assays for Estimating the Effects of Efflux Transporters on Cell Permeation.- In Vitro Models for Estimating Hepatobiliary Clearance.- Challenges in Drug Discovery: Lead Optimization and Prediction of Human Pharmacokinetics.- Free Drug! The Critical Importance of Plasma Protein Binding in NewDrug Discovery.- Use of In Vitro ADME Screens to Develop Orally Bioavailable and CNS-Permeable Neuropeptide Y Y5 Antagonists.- Applying Computational and In Vitro Approaches to Lead Selection.- Strategies for In Silico and Experimental Screening of Physiochemical Properties.- The Challenge of Quality in Candidate Optimization.- A Comprehensive Strategy for ADME Screening in Drug Discovery.- Scientific, Educational, and Communication Issues Associated with Integrating and Applying Drug-Like Properties in Drug Discovery.

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