Pharmacogenomics in Clinical Therapeutics

Overview

Pharmacogenomics is the process of analyzing patients' genes to predict the onset of adverse reactions or forecast the effectiveness of therapeutic drugs. This useful text is written to discuss both the theory and the clinical application of the principles of pharmacogenomics. Current research has clearly established that a range of treatments may be greatly improved through genetic profiling of individual patients before certain therapies begin. Aimed at clinicians, pharmacologists, and clinical laboratory ...

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Overview

Pharmacogenomics is the process of analyzing patients' genes to predict the onset of adverse reactions or forecast the effectiveness of therapeutic drugs. This useful text is written to discuss both the theory and the clinical application of the principles of pharmacogenomics. Current research has clearly established that a range of treatments may be greatly improved through genetic profiling of individual patients before certain therapies begin. Aimed at clinicians, pharmacologists, and clinical laboratory professionals this book discusses the important role of laboratory tests in the practice of personalized medicine. An important new book, Pharmacogenomics in Clinical Therapeutics serves as a guide to the basic principles of pharmacogenomics in a range of common therapeutic areas and as the basis of the personalized medicine of the future.

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Editorial Reviews

Doody's Review Service
Reviewer: Xiaochao Ma, PhD (University of Kansas Medical Center)
Description: This practical book covers principles, applications, and methodology of pharmacogenomics in clinical therapeutics.
Purpose: It is intended to present comprehensive coverage of pharmacogenomics and to highlight the applications in clinical therapeutics.
Audience: This book is valuable for physicians and scientists who use or want to use genetic approaches to monitor drug safety and efficacy.
Features: It starts with principles of pharmacogenomics and personalized medicine. The main body of the book illustrates applications of pharmacogenomics in warfarin therapy, cancer chemotherapy, anesthesia and pain management, immunosuppressants, cardiovascular drugs, antiretroviral therapy, psychoactive drugs, and adverse drug-drug interactions. It also details methodology of pharmacogenomics for clinical practice.
Assessment: This book is unique in its focus on the application of pharmacogenomics in clinical therapeutics.
From the Publisher
“This book is unique in its focus on the application of pharmacogenomics in clinical therapeutics.”  (Doody’s,
19 January 2013)
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Product Details

  • ISBN-13: 9780470657348
  • Publisher: Wiley
  • Publication date: 2/28/2012
  • Edition number: 2
  • Pages: 256
  • Product dimensions: 7.50 (w) x 9.80 (h) x 0.80 (d)

Table of Contents

List of Contributors, vii

Preface, ix

1 Pharmacogenomics Principles: Introduction to Personalized Medicine, 1
Parvaz Madadi, PhD and Gideon Koren, MD

2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? 15
Christine L.H. Snozek, PhD, Loralie J. Langman, PhD, and Amitava Dasgupta, Ph.D

3 Pharmacogenomics Aspect of Warfarin Therapy, 26
Matthew D. Krasowski, MD, PhD

4 Pharmacogenetics and Cancer Chemotherapy, 39
Christine L.H. Snozek

5 Pharmacogenomic Considerations in Anesthesia and Pain Management, 53
Christine M. Formea, PharmD and Wayne T. Nicholson, MD, PharmD

6 Pharmacogenomics of Immunosuppressants, 70
Nicolas Picard, PharmD, PhD and Pierre Marquet, MD, PhD

7 Pharmacogenomics of Cardiovascular Drugs, 98
Linnea M. Baudhuin, PhD

8 Pharmacogenomic Aspects of Antiretroviral Therapy, 127
Natella Y. Rakhmanina, MD, PhD and John N. van den Anker, MD, PhD

9 Pharmacogenetics of Psychoactive Drugs, 144
Jorge L. Sepulveda, MD, PhD

10 Pharmacogenomic Aspects of Adverse Drug–Drug Interactions, 176
Loralie J. Langman, PhD and Christine L.H. Snozek, PhD

11 Microarray Technology and Other Methods in Pharmacogenomics Testing, 185
Jorge L. Sepulveda, MD, PhD

12 Pharmacogenetic Testing in the Clinical Laboratory Environment, 201
Mark P. Borgman, PhD and Mark W. Linder, PhD

Index, 225

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