Pharmacogenomics: Social, Ethical, and Clinical Dimensions / Edition 1

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Pharmacogenomics promises to revolutionize medicine by enabling the prevention, diagnosis, and treatment of diseases at the genome level. While a substantial amount of public and private research focuses on new pharmacogenomic applications, notably less attention has been directed to the ethical, legal, and social implications of "individualized medicine." Mark Rothstein's timely anthology reduces that scholarship deficit, presenting a multidisciplinary analysis of the scientific, clinical, economic, ethical, social, and legal implications of pharmacogenomics. Assembling an all-star cast of bioethical scholars, medical researchers, legal scholars, and social scientists, Mark Rothstein examines the promises, questions, and concerns these revolutionary therapies implicitly present. Among other features, Pharmacogenomics: Reports for the first time the results of the first detailed, national survey of public attitudes regarding pharmacogenomics Covers informed consent, privacy, confidentiality, and risk-benefit evaluations Analyzes the potentially enormous changes in the standard of care and the approach to treatment with the development and application of pharmacogenomic technology Addresses practical considerations of education, training, oversight, guidelines and protocols, and continuing education requirements Recommends approaches to respond to the more complex issues of safety, efficacy, and quality in the distribution and development of individualized therapies Explores the new legal standards and implementation challenges Offers a policy framework that balances the benefits and risks and considers the wide range of legislative, regulatory, and professional options Biotechnology and pharmaceutical researchers and regulators, health care professionals and students, and academics and policymakers will find Pharmacogenomics to be a valuable resource.

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Editorial Reviews

From the Publisher
"The discussion of societal, legal, economic, and governmental issues go well beyond the sphere of pharmogenomics." (American Journal for Medical Genetics, September 1, 2005)

"...indispensable timely as it can impressive multidisciplinary analysis...a 'must read'..." (Bioethics, Vol 18(4), August 2004)

"…Pharmacogenomics is highly recommended for anyone with an interest in the field…. Given this book's uniqueness…libraries at any institution teaching pharmcogenomics should have a copy of this book.” (Journal of Pharmacy Technology, Sept/Oct 2003)

"...well written, clear, and informative...a restrained sense of excitement...permeates throughout...clearly...a solid contribution to the discourse." (Nature Biotechnology, May 1, 2003)

"...chapters offer fascinating glimpses into fields that may not be familiar to geneticists, genomicists, or clinicians...they will be informative...and provide a reminder that many people outside this field are going to be paying a lot of attention as discoveries...are reported." (New England Journal of Medicine, July 24, 2003)

" excellent summary of aspects of phamacogenomics...a solid reference for those working in the field and a unique textbook for those new to the subject area." (Clinical Chemistry, Vol. 49, No. 9)

"...a welcome addition to the growing body of literature...highly recommended for anyone with an interest in the field...should be required reading for anyone conducting pharmacogenomic research and for all clinicians who use pharmacogenomics..." (Journal of Pharmacy Technology, Vol. 19September/October 2003)

"...addresses the ethical, legal, and social implications of the individualized medicine that pharmacogenomics stands to create..." (Genetic Engineering News, Vol 23(14), 2003)

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Product Details

  • ISBN-13: 9780471227694
  • Publisher: Wiley
  • Publication date: 1/23/2003
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 384
  • Product dimensions: 6.40 (w) x 9.69 (h) x 0.92 (d)

Table of Contents

Foreword (F. Collins).



Public Attitudes About Pharmacogenomics (M. Rothstein, et al.).

Pharmacogenomics:  Pharmacology and Toxicology in the Genomics (H. Mohrenweiser).

The Implications of Population Genetics for Pharmacogenomics (C. Hanis).


Genome Research and Minorities (H. Greely).

Drug Development Strategies (P. Manasco & T. Arledge).

Drug Development,  Regulation, and Genetically Guided Therapy Pharmacogenomics (D. Feigal & S. Gutman).

Intellectual Property and Commercial Aspects of Pharmacogenomics (A. Nunnally,  et al.).


Integration of Pharmacogenomics into Medical Practice (G. Omenn & A. Motulsky).

Clinical Utility Pharmacogenetics and Pharmacogenomics (N. Holtzman).

Medical Liability for Pharmacogenomics (L. Palmer).

The Challenges of Pharmacogenomics for Pharmacy Education, Practice, and Regulation  (D. Brushwood).


Economic Implications of Pharmacogenomics (C. Reeder & W. Dickson). 

 Pharmacogenomics and the Social Construction of Identity (M. Foster).

Pharmacogenomics: Considerations for Communities of Color (L. Nsiah-Jefferson).

Constitutional Issues in the Use of Pharmacogenomic Variations Associated with Race (J. Robertson).


Pharmacogenomics and Minority Populations: General Population Survey Questionnaire (M. Rothstein).


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  • Anonymous

    Posted August 19, 2003

    Pharmacogenomics: Social, Ethical, and Clinical Dimensions

    '...chapters offer fascinating glimpses into fields that may not be familiar to geneticists, genomicists, or clinicians...they will be informative...and provide a reminder that many people outside this field are going to be paying a lot of attention as discoveries...are reported.' (New England Journal of Medicine, July 24, 2003)

    Was this review helpful? Yes  No   Report this review
  • Anonymous

    Posted June 19, 2003

    Pharmacogenomics: Social, Ethical, and Clinical Dimensions

    ¿¿well written, clear, and informative¿a restrained sense of excitement¿permeates throughout¿clearly¿a solid contribution to the discourse.¿ (Nature Biotechnology, May 1, 2003)

    Was this review helpful? Yes  No   Report this review
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