Pharmacogenomics of Alcohol and Drugs of Abuse

Overview

Pharmacogenomics is the basis of personalized medicine, which is said to be the medicine of the future. Understanding genetic variation in drug and alcohol response is vital for professionals working in rehabilitation programs. The same principles that are applicable for therapeutic drugs are also applicable for drugs of abuse. Pharmacogenomics can supplement traditional therapeutic drug monitoring, potentially predicting correct dosage before initiation of the drug therapy.

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Overview

Pharmacogenomics is the basis of personalized medicine, which is said to be the medicine of the future. Understanding genetic variation in drug and alcohol response is vital for professionals working in rehabilitation programs. The same principles that are applicable for therapeutic drugs are also applicable for drugs of abuse. Pharmacogenomics can supplement traditional therapeutic drug monitoring, potentially predicting correct dosage before initiation of the drug therapy.

Applying these principles to testing and treatment, Pharmacogenomics of Alcohol and Drugs of Abuse discusses the role of the clinical laboratory in the practice of personalized medicine. With contributions from a range of experts, the book presents the genetic aspects of alcohol metabolism and other drugs including marijuana, cocaine, and amphetamines. In addition to basic pharmacogenomic aspects, the book addresses slate and trait markers of drugs of abuse so readers can consider setting appropriate biomarker tests in their clinical laboratory.

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Product Details

  • ISBN-13: 9781439856116
  • Publisher: CRC Press
  • Publication date: 5/3/2012
  • Pages: 252
  • Product dimensions: 6.20 (w) x 9.20 (h) x 0.80 (d)

Meet the Author

Amitava Dasgupta is a Professor of Pathology and Laboratory Medicine at the University of Texas-Houston Medical School. Loralie Langman is an Associate Professor of Laboratory Medicine at the Mayo Clinic, Rochester, Minnesota.

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Table of Contents

Pharmacogenomics Principles and Molecular Mechanisms of Action of Alcohol and Abused Drugs
Christine L.H. Snozek and Loralie J. Langman
Alcohol: Use and Abuse
Amitava Dasgupta
Slate and Trait Markers of Alcohol Abuse
Joshua Bornhorst, Annjanette Stone, John Nelson, and Kim Light
Introduction to Drugs of Abuse
Larry Broussard and Catherine Hammett-Stabler
Pharmacogenomics of Amphetamine and Related Drugs
Steven C. Kazmierczak
Pharmacogenomics of Cocaine
Loralie J. Langman and Christine L.H. Snozek
Genetic Aspect of Marijuana Metabolism and Abuse
Pradip Datta
Genetic Aspect of Opiate Metabolism and Addiction
Jorge L. Sepulveda
Pharmacogenomics Aspects of Addiction Treatment
F. Gerard Moeller
Methodologies in Pharmacogenetics Testing
Jorge L. Sepulveda
Index

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