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Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation

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Overview

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis...

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Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation

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Overview

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.

  • Multi-contributed book and chapters are written by contributors who are experts in their field
  • Provides perspectives from those involved in all aspects of pharmacogenomics-including academic, regulatory, economic, industry and medical-to illustrate how all of the pieces fit together and where the challenges may be
  • Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications
  • Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research
  • A companion website offers an elaboration on key points and discussion questions and provides patient case scenarios that illustrate how pharmacogenomics may be applied to a clinical setting
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Editorial Reviews

From the Publisher
"Lam and Cavallari bring together pharmacy and other specialists from North America, Europe, and Asia for 13 chapters aimed at scientists, clinicians, and students in health and pharmaceutical sciences. The chapters consider the translation of pharmacogenomic findings into therapeutic applications from academic, regulatory, pharmaceutical, clinical, socioethical, and economic perspectives."—Reference and Research Book News, August 2013 "This book succeeds in providing a relevant and unique perspective, by international experts in the field, on the progress and challenges facing the translation of pharmacogenomics into clinical practice. I highly recommended it to anyone with an interest in the topic, from the essential basics to its role in the future practice of medicine."—Doody.com, August 2, 2013
Doody's Review Service
Reviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: Although much progress has been made translating information gained from the Human Genome Project to its application in personalized medicine, there are still many challenges. This book deals with the successes as well as the challenges that must be addressed.
Purpose: The goal is to provide a timely discussion of a broad range of topics and viewpoints from academic, regulatory, pharmaceutical, clinical, socio-ethical, and economic perspectives facing the translation of personalized medicine into clinical practice. It is very well done.
Audience: This book is written for scientists, clinicians, and students who are interested in any aspect of pharmacogenomics and the translation of the scientific principles of this discipline into clinical practice.
Features: The first three chapters cover introductory information germane to the discipline, including basic principles of pharmacogenomics, translating this science into therapeutic potentials, and, finally, the role of governmental and academic groups in advancing the field of pharmacogenomics. Chapters 4 to 7 deal with the advances that have occurred in applying pharmacogenomics to the treatment of cancer, cardiovascular disease, psychiatric disorders, diabetes, HIV infections, and pain management. Each of these areas has an addendum section addressing future perspectives. The final four chapters explore molecular approaches, experimental design and modeling strategies, clinical studies, ethnobridging issues, relevance to general health assessment, and integrating genomics into pharmacy education and practice. Chapters have a uniform format, beginning with a textbox giving the objectives, an introductory section, a concise presentation, and ending with a concise conclusion and a list of questions for discussion. Each chapter presents state-of-the-art progress information as well as challenges that have to be met for the successful application of this discipline to clinical practice. A companion website offers elaboration on key points and discussion questions and provides patient scenarios that illustrate how pharmacogenomics may be applied to clinical practice.
Assessment: This book succeeds in providing a relevant and unique perspective, by international experts in the field, on the progress and challenges facing the translation of pharmacogenomics into clinical practice. I highly recommended it to anyone with an interest in the topic, from the essential basics to its role in the future practice of medicine.
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Product Details

  • ISBN-13: 9780123919182
  • Publisher: Elsevier Science
  • Publication date: 3/22/2013
  • Pages: 510
  • Sales rank: 1,098,077
  • Product dimensions: 7.50 (w) x 9.40 (h) x 1.00 (d)

Meet the Author

Professor of Pharmacology, Department of Pharmacology and Associate Professor, Department of Medicine, The University of Texas Health Science Center at San Antonio

Associate Professor, Department of Pharmacy Practice, University of Illinois at Chicago

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Table of Contents

SECTION 1

1Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications 2Translating Pharmacogenomic Research to Therapeutic Potentials 3Governmental and Academic Efforts to Advance the Field of Pharmacogenomics (PGRN CPIC, PharmGKB)

Section 2

4aPharmacogenomics in Cancer Therapeutics 4bA Look to the Future: Cancer epigenetics 5aPharmacogenomics in Cardiovascular Diseases 5bA Look to the Future: Cardiovascular Pharmaco-epigenetics 6aPharmacogenomics in Psychiatry Disorders 6bA Look to the Future: Epigenetics in psychiatric disorders and treatment 7Role of Pharmacogenomics in Diabetes and Other Therapeutic Areas

SECTION 3

8aMolecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development 8bMolecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development 9aIncorporating Pharmacogenomics in Drug Development Part 1: Rational study designs for pharmacogenetic research and therapy - A perspective from academia 9bIncorporating Pharmacogenomics in Drug Development Part 2: A perspective from industry 10Ethnobridging and Pharmacogenomics

SECTION 4

11Beyond ELSIs - Where to from here? From 'Regulator' to Anticipating and Shaping the Innovation Trajectory in Personalized Medicine 12The Economics of Pharmacogenomics

SECTION 5

13Integrating Genomics into Pharmacy Education and Practice: Pharmacogenomics is not enough

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Customer Reviews

Average Rating 4.5
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  • Anonymous

    Posted June 16, 2014

    Bw

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    Posted July 8, 2013

    Trev

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    Posted March 31, 2013

    Can i b shadowfites mate

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    Posted March 31, 2013

    Silverwings

    Silverwings calls her cloud and helps Shadowfire up. They float over twoleg roofs and land softly to 'cloud' result one.

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    Posted March 31, 2013

    Silvertail

    A beautiful sheek she she sits in the farthest corner to the left. Her wandering stain glass window eyes shine and give off a beautiful reflection. She slowely moves her paw out of the corner and into a blossom of sun. She then moves all the way, thats when you see her face. Its a slim and beautiful face, surrounded by the softest of fur. Her tail is all the way silver but her body is silver and a shimmery creme. "Hello, my name is Silvertail." She mews softly looking at her paws, on the top of her head theres a scar. A cougar had attacked her and killed her newly born niece. She feels she os showing the scar so swiftly moves her head upwards and meets your eyes.

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    Posted March 31, 2013

    Shadowfire

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