Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation

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by Yui-Wing Francis Lam
     
 

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Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and

Overview

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.

  • Multi-contributed book and chapters are written by contributors who are experts in their field
  • Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be
  • Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications
  • Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research
  • A companion website offers an elaboration on key points and discussion questions and provides patient case scenarios that illustrate how pharmacogenomics may be applied to a clinical setting

Editorial Reviews

From the Publisher
"...a practical and indispensable resource on both the opportunities and challenges that allows readers to reflect on the future direction of pharmacogenomics while applying these observations to their own work or research."—Anticancer Research, February 2015

"Lam and Cavallari bring together pharmacy and other specialists from North America, Europe, and Asia for 13 chapters aimed at scientists, clinicians, and students in health and pharmaceutical sciences. The chapters consider the translation of pharmacogenomic findings into therapeutic applications from academic, regulatory, pharmaceutical, clinical, socioethical, and economic perspectives."—Reference and Research Book News, August 2013 "This book succeeds in providing a relevant and unique perspective, by international experts in the field, on the progress and challenges facing the translation of pharmacogenomics into clinical practice. I highly recommended it to anyone with an interest in the topic, from the essential basics to its role in the future practice of medicine."—Doody.com, August 2, 2013

Doody's Review Service
Reviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: Although much progress has been made translating information gained from the Human Genome Project to its application in personalized medicine, there are still many challenges. This book deals with the successes as well as the challenges that must be addressed.
Purpose: The goal is to provide a timely discussion of a broad range of topics and viewpoints from academic, regulatory, pharmaceutical, clinical, socio-ethical, and economic perspectives facing the translation of personalized medicine into clinical practice. It is very well done.
Audience: This book is written for scientists, clinicians, and students who are interested in any aspect of pharmacogenomics and the translation of the scientific principles of this discipline into clinical practice.
Features: The first three chapters cover introductory information germane to the discipline, including basic principles of pharmacogenomics, translating this science into therapeutic potentials, and, finally, the role of governmental and academic groups in advancing the field of pharmacogenomics. Chapters 4 to 7 deal with the advances that have occurred in applying pharmacogenomics to the treatment of cancer, cardiovascular disease, psychiatric disorders, diabetes, HIV infections, and pain management. Each of these areas has an addendum section addressing future perspectives. The final four chapters explore molecular approaches, experimental design and modeling strategies, clinical studies, ethnobridging issues, relevance to general health assessment, and integrating genomics into pharmacy education and practice. Chapters have a uniform format, beginning with a textbox giving the objectives, an introductory section, a concise presentation, and ending with a concise conclusion and a list of questions for discussion. Each chapter presents state-of-the-art progress information as well as challenges that have to be met for the successful application of this discipline to clinical practice. A companion website offers elaboration on key points and discussion questions and provides patient scenarios that illustrate how pharmacogenomics may be applied to clinical practice.
Assessment: This book succeeds in providing a relevant and unique perspective, by international experts in the field, on the progress and challenges facing the translation of pharmacogenomics into clinical practice. I highly recommended it to anyone with an interest in the topic, from the essential basics to its role in the future practice of medicine.

Product Details

ISBN-13:
9780123983039
Publisher:
Elsevier Science
Publication date:
02/12/2013
Sold by:
Barnes & Noble
Format:
NOOK Book
Pages:
510
File size:
9 MB

Meet the Author

Professor of Pharmacology, Department of Pharmacology and Associate Professor, Department of Medicine, The University of Texas Health Science Center at San Antonio

Associate Professor, Department of Pharmacy Practice, University of Illinois at Chicago

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Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation 5 out of 5 based on 0 ratings. 4 reviews.
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