Pharmacokinetics: Processes, Mathematics, and Applications / Edition 2

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Overview


Pharmacokinetics is the study of the absorption, distribution, metabolism, and excretion of drugs in humans. This book, written by an internationally known researcher, teaches the basic principles, including drug transport, parenteral and enteral routes of drug administration, and factors affecting drug absorption, distribution, and metabolism. Extensively revised, this edition presents the mathematics of pharmacokinetics with various single- and multi-compartment models including detailed descriptions of metabolite and nonlinear pharmacokinetics. It also describes renal and hepatic drug clearance, and the influence of kidney and liver impairment on these functions. Taking a tutorial approach throughout, the author provides both a clear introduction to pharmacokinetics and a critical look at how this science affects drug discovery and development.
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Editorial Reviews

Booknews
Revised to reflected changes in pharmacokinetics and drug metabolism since the first edition of 1986, this book provides new material on drug transport and drug disposition in patients with hepatic or renal function impairment. A new section on the applications of pharmacokinetics and drug metabolism in drug discovery and development offers a critical comparison of pharmacokinetics and toxicokinetics as contributing disciplines in drug development. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780841234819
  • Publisher: American Chemical Society
  • Publication date: 1/28/1997
  • Series: ACS Professional Reference Book Series
  • Edition description: REV
  • Edition number: 2
  • Pages: 400
  • Product dimensions: 9.30 (w) x 7.40 (h) x 1.00 (d)

Table of Contents

Preface
Drug Absorption, Distribution, Metabolism, and Excretion 1
1 Drug Absorption, Distribution, Metabolism, and Excretion 3
2 Drug Transport 11
3 Parenteral Routes of Drug Administration 19
4 Enteral Routes of Drug Administration 43
5 Factors Influencing Absorption and Bioavailability After Enteral Administration 63
6 Physicochemical and Formulation Factors Affecting Drug Absorption 75
7 Clinical Factors and Interactions Affecting Drug Absorption 95
8 Drug Distribution 119
9 Drug Metabolism 145
10 Effect of Liver Disease on Drug Metabolism and Pharmacokinetics 163
11 Renal Excretion 175
12 Drug Elimination in Renal Impairment 187
The Mathematics of Pharmacokinetics 199
13 The One-Compartment Open Model with Intravenous Dosage 201
14 The One-Compartment Open Model with First-Order Absorption and Elimination 223
15 Multiple-Dose Kinetics 245
16 Metabolite Pharmacokinetics 259
17 The Two-Compartment Open Model with Intravenous or Oral Administration 271
18 Physiological Pharmacokinetics Models 297
19 Nonlinear Pharmacokinetics 311
Applications of Pharmacokinetics in Drug Discovery and Development 323
20 Pharmacokinetics and Toxicokinetics 325
21 Role of Pharmacokinetics in Drug Discovery and Development 331
22 Integration of Pharmacokinetics into Research and Development 343
App. I Computer Methods and Software for Pharmacokinetic Data Analysis 357
App. II Worked Answers to Problem Sets 359
App. III Nomenclature 373
App. IV Glossary 377
Index 381
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