Pharmacokinetics is the study of the absorption, distribution, metabolism, and excretion of drugs in humans. This book, written by an internationally known researcher, teaches the basic principles, including drug transport, parenteral and enteral routes of drug administration, and factors affecting drug absorption, distribution, and metabolism. Extensively revised, this edition presents the mathematics of pharmacokinetics with various single- and multi-compartment models including detailed descriptions of metabolite and nonlinear pharmacokinetics. It also describes renal and hepatic drug clearance, and the influence of kidney and liver impairment on these functions. Taking a tutorial approach throughout, the author provides both a clear introduction to pharmacokinetics and a critical look at how this science affects drug discovery and development.
Revised to reflected changes in pharmacokinetics and drug metabolism since the first edition of 1986, this book provides new material on drug transport and drug disposition in patients with hepatic or renal function impairment. A new section on the applications of pharmacokinetics and drug metabolism in drug discovery and development offers a critical comparison of pharmacokinetics and toxicokinetics as contributing disciplines in drug development. Annotation c. by Book News, Inc., Portland, Or.