Description: This book contains excellent discussions on current pharmacokinetic and pharmacodynamic topics and regulatory issues that affect drug discovery and development.
Purpose: The purpose is to present the latest concepts and developments in the area of pharmacokinetics from the perspective of authorities in the regulatory, industrial, and academic environments. This second edition of the textbook has new topics and current issues that have rapidly evolved since the first edition in 1988.
Audience: The intended audience includes industrial, regulatory, and research scientists interested in the areas of pharmacokinetics, pharmacodynamics, and biopharmaceutics. The book will is also be useful to pharmacologists, pharmacists, and graduate students.
Features: The book is well organized and arranged with a logical separation of chapters. The tables and black-and-white figures are well presented. All chapters have thorough and up-to-date references. The book is enhanced by an excellent index. The editors and authors are recognized experts actively involved in pharmacokinetic research. This book represents volume 67 of the excellent series, Drugs and the Pharmaceutical Sciences.
Assessment: The book contains wonderful discussions on good laboratory practice regulations; issues of drug, peptide, and protein drug delivery; membrane and blood-brain barrier transport; and methodologies for assessing drug metabolism. Detailed descriptions are given on the clinical and nonclinical aspects of pharmacokinetics in drug discovery and development. Extensive overviews are included on pharmacokinetic and pharmacodynamic modeling relationships and population data analysis. The statistical and regulatory perspectives of bioavailability and bioequivalence are presented. The book will serve as an excellent reference to scientists and graduate students who are interested in pharmacokinetics, pharmacodynamics, and biopharmaceutics.