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Doody's Review ServiceReviewer: Michael Easton, MD (Rush University Medical Center)
Description: This is a review of the neuropharmacology and behavioral pharmacology of drugs of abuse.
Purpose: The purpose is to comprehensively review the basic science and animal research regarding drug addiction and how this relates to present pharmacotherapy development and research for these disorders.
Audience: It is intended for individuals interested in the basic science and preclinical research in addiction, those interested in therapeutic drug development for these disorders, and other interested clinicians. It is a technical publication, and some fundamental understanding of neurobiology is necessary to fully comprehend this text.
Features: The book has an appropriate number of illustrations, tables, and charts. It is well referenced, and the editors and multiple authors are experts in their areas.
Assessment: This is a highly specialized and technical publication looking at a number of areas, including genetic vulnerability, neurobiology, cellular mechanisms of action, neurobehavioral pharmacology, and systemic effects of drugs of abuse. The book focuses on cocaine, opiates, nicotine, caffeine, alcohol, PCP, and hallucinogens. The final chapters look at the clinical application of pharmacotherapy in addictions. It extensively reviews treatments for opiate dependence and to a lesser degree nicotine dependence. There is some information on cocaine dependence, and it is devoid of any information on pharmacotherapy for alcoholism. This is a fairly comprehensive text, but it offers little new information or insights. Most of this information can be found in other resources.