Pharmacological Control of Calcium and Potassium Homeostasis: Biological, Therapeutical, and Clinical Aspects / Edition 1

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This up to date treatment of calcium and potassium channel pharmacology first presents both molecular and preclinical pharmacology data, followed by contributions on the clinical application of the drugs that modulate calcium and potassium channels. Cardiovascular data prevail, but other chapters also discuss possible roles and application to the nervous system. Further, some contributions deal with future prospects in the area.
Audience: Researchers, both pharmacological and medical, working in cardiovascular medicine with strong interests in the treatment of myocardial infarction and hypertension.

The book contains black-and-white illustrations.

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Editorial Reviews

Thirty papers from the 6th International Symposium on Pharmacological Control of Calcium and Potassium Homeostasis: Biological, Therapeutical, and Clinical Aspects, in Florence, Italy, October 1994. The presentations discuss the numerous drugs which act on calcium and potassium channels, and the cellular machinery controlling them; and provide updates on basic knowledge, the molecular targets of the two channels, and the importance that the drugs which bind them have as pharmacological tools and therapeutic agents. These themes are divided into eight sections which deal with specific issues in cardiovascular, cerebral, and molecular areas. The index is very small considering the scope of the work. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780792336044
  • Publisher: Springer Netherlands
  • Publication date: 8/22/2007
  • Series: Medical Science Symposia Series, #9
  • Edition description: 1995
  • Edition number: 1
  • Pages: 275
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.69 (d)

Table of Contents

Preface. I: Molecular biology and pharmacology of cell calcium and potassium. II: Calcium and potassium regulation in cardiovascular pathophysiology. III: Calcium antagonists in cardiovascular therapy and organ protection. IV: Calcium and potassium manipulation in the prevention and reversal of structural changes in hypertension. V: Beyond blood pressure reduction: tissue protection by calcium antagonism can be enhanced by ACE inhibitors. VI: Multicenter Israpidine diuretic atherosclerosis study (MIDAS): results and lessons learned. VII: Calcium and potassium homeostasis in cerebral ischemia and neurodegenerative disorders. VIII: Molecular and clinical aspects of current and novel uses of potassium channel openers. Index.
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