Pharmacological Effects of Ethanol on the Nervous System / Edition 1

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Overview

This book dissects the effects of ethanol on the major neurotransmitter systems affected by ethanol and correlates these actions with the behavioral consequences. The subject is approached first from the perspective of the neurochemical system and the behaviors resulting from ethanol's effects on that system. The behaviors themselves are discussed in later chapters. Some older theories of the effects of ethanol such as the membrane fluidization hypothesis are evaluated in light of new and updated information. Fetal Alcohol Syndrome (FAS) as well as the structural damage in the brain by long term ethanol exposure are also discussed.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Michael Easton, MD (Rush University Medical Center)
Description: This is a review and update of recent advances regarding the neurobiological effects of alcohol.
Purpose: The purpose is to examine the cellular effects of alcohol that are responsible for mediating behaviors leading to its abuse.
Audience: The book is written for individuals interested in the central nervous system effects of habit-forming substances on a cellular level. It is also intended for individuals involved in the pharmacological treatment of addictive disorders as well as those trying to obtain a better understanding of the biological underpinnings of these disorders.
Features: The book has limited illustrations, tables, and charts, but those present are useful. It is well referenced, and the editors and authors are experts in their particular areas.
Assessment: This is a highly specialized and technical publication looking at the neurobiological consequences of alcohol related to its reinforcing, addictive, and toxic properties. It begins by reviewing the molecular, cellular, and receptor effects of alcohol. It builds on this information by reviewing how these phenomena lead to behavioral effects (in animals). It finishes by looking at the toxic effects of alcohol on the central nervous system. This is an excellent reference for those interested in newer insights into alcohol's neurochemical effects leading to its abuse and toxicity.
Michael Easton
This is a review and update of recent advances regarding the neurobiological effects of alcohol. The purpose is to examine the cellular effects of alcohol that are responsible for mediating behaviors leading to its abuse. The book is written for individuals interested in the central nervous system effects of habit-forming substances on a cellular level. It is also intended for individuals involved in the pharmacological treatment of addictive disorders as well as those trying to obtain a better understanding of the biological underpinnings of these disorders. The book has limited illustrations, tables, and charts, but those present are useful. It is well referenced, and the editors and authors are experts in their particular areas. This is a highly specialized and technical publication looking at the neurobiological consequences of alcohol related to its reinforcing, addictive, and toxic properties. It begins by reviewing the molecular, cellular, and receptor effects of alcohol. It builds on this information by reviewing how these phenomena lead to behavioral effects (in animals). It finishes by looking at the toxic effects of alcohol on the central nervous system. This is an excellent reference for those interested in newer insights into alcohol's neurochemical effects leading to its abuse and toxicity.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780849383892
  • Publisher: CRC Press
  • Publication date: 12/21/1995
  • Series: Handbooks in Pharmacology and Toxicology Series , #32
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 480
  • Product dimensions: 7.20 (w) x 10.30 (h) x 1.10 (d)

Table of Contents

Introduction, R.A. Deitrich and V.G. Erwin
Overview, G. Koob
Section I: Effects of Ethanol at the Molecular/Cellular Level
Cell Membrane Structure, W.G. Wood, F. Schroeder, R.M. Adibhatla, U. Igbavboa, N.A. Avdulov
Calcium Channels, D. Mullikin-Kilpatrick and S.N. Treistman
Chloride Channels/GABA, S.J. Mihic and R. A. Harris
Glutamate Receptors, B. Tabakoff and P.L. Hoffman
Cholinergic Systems, A.C. Collins
Phosphorylation, K. T. Eggeman and M.D. Browning
G-Proteins, F.Y.G. Lee, Sr. and G.S. Wand
Adenosine, T.V. Dunwiddie
Neurotensin, V.G. Erwin
Peptides, G.R. Siggins, Z. Nie, P. Schweitzer, S. Madamba, S.J. Henriksen
Thyrotropin Releasing Hormone, T.J. McCown and G.R. Breese
Section II: Behavioral Effects of Ethanol
Ethanol Intake, H.H. Samson and C.W. Hodge
Initial Sensitivity, L.J. Draski and R.A. Deitrich
Acute Tolerance, A.D. Le and J.M. Mayer
Dependence and Withdrawal, P. Metten and J.C. Crabbe
Ethanol's Acute Effects on Thermoregulation: Mechanisms and Consequences, R. Alkana and A.D. Le
Section III: Toxicity of Ethanol in the Central Nervous System
Free Radicals, R. Nordmann and H. Rouach
Fetal Damage-Mechanisms, W.-J.A. Chen, S.E. Maier, and J.R. West
Structural Damage, M.E. Charness
Neurological Damage and Stroke, M.E. Hillbom
Fetal Damage-Behavior, H.C. Becker

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