Pharmacology / Edition 4

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2001 Trade paperback 4th ed. New. No dust jacket as issued. lt shelf wear...Book Is New! Trade paperback (US). Glued binding. 839 p. Contains: Illustrations. Audience: ... General/trade. Read more Show Less

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Overview

Adapted for the U.S., this New Edition of PHARMACOLOGY, a popular UK text, describes what drugs do and emphasizes the mechanisms by which they act. The U.S. edition is revised and updated to reflect the substantial differences in drug names, FDA approvals, terminology, and guidelines for use. It also boasts new and revised chapters to ensure that students are up to date on the very latest information. Each chapter begins with a summary of information essential to the chapter and key points are highlighted within the text to alert students to crucial concepts.

Spanish version also available, ISBN: 84-8174-492-1

"...a concise introduction to the fundamental principles of pharmacology and mechanisms of drug action that focuses on how drugs work--on the cellular and molecular level when possible...features FDA-approved drugs only."

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Editorial Reviews

From The Critics
Reviewer: Jean Deupree, PhD(University of Nebraska Medical Center)
Description: "This comprehensive pharmacology textbook describes the therapeutic effects of drugs and their mechanisms of action. The previous edition was published in 1995. "
Purpose: The purpose is to provide basic pharmacology information for medical and pharmacy students. This has been a popular pharmacology textbook in Europe and Asia. This and the previous edition were adapted for the North American market, taking into consideration the differences in drug names and more complex changes attributed to differences in approved drugs and drug usage in the United States. The approach of this book has been to describe what the drugs do and how they act.
Audience: The primary market for this book is for medical, dental, and pharmacy students with a secondary market being graduate students and nurse practitioners. The book contains more information than we usually teach dental or nurse practitioner students. However, it is a very good textbook for graduate students, medical, and pharmacy students. Physician assistant students will also benefit from some aspects of this book.
Features: This book covers all of the major topics taught to medical professionals. The introductory chapters cover the basic pharmacokinetic and pharmacodynamic properties of drugs in more detail than most books, which is helpful for any healthcare professional because it teaches the language of pharmacology and helps in understanding the drug literature. Some of the new chapters cover gene therapy, pathophysiology and treatment of obesity. Chapters on anticancer therapies, cardiovascular pharmacology, peptides and protein mediators, nitric oxide, and immunity and immunosuppressants have been updated to reflect the changes in our knowledge and the new drug treatment strategies. Some particularly helpful features are: key points set off in boxes, introductory summaries of relevant physiological and biochemical processes at the beginning of each chapter, annotation in the references indicating review articles and figures that are helpful to the instructors. The images are easy to understand and the color has been changed to make them more visually appealing. The clinical uses of the drugs are presented in boxes making it easy to get the information at a glance. Pharmacokinetic properties of individual drugs is sufficient information for most physicians, but in less detail than needed by pharmacists, particularly those acting as drug consultants. Historical information on drug discovery and the experimental effects of drugs on animals is in more detail than needed by most medical professionals. Although adverse effects are listed, there is little emphasis on them. A particularly helpful appendix contains a list disease entities and the primary and secondary drugs used for treatment.
Assessment: The field of pharmacology is rapidly changing as new information on mechanism of action is discovered and new drugs are found. The method of teaching pharmacology to medical processionals is also changing from teaching students all there is to know about pharmacology to teaching them the most important things they need to know in order to appropriately use drugs. This textbook does an excellent job of presenting the basic pharmacokinetic and pharmacodynamic information, but for medical personnel it overemphasizes the research aspects of pharmacology and underemphasizes the therapeutic aspects. The balance between these two aspects of pharmacology that this book presents is not as good as that presented in Katzung's Basic and Clinical Pharmacology, 8th edition (McGraw-Hill, 2001). However, this book provides summaries of relevant physiological and biochemical processes at the beginning of each chapter that are particularly helpful for students with weak biochemical and physiological backgrounds.
Booknews
New edition (first in 1987) of a textbook for preclinical medical students and science students, with all sections updated, many new agents included as well as extensions of the basic knowledge which presage further drug development, and new sections on new topics such as 5-HT, peptides as mediators, amino-acid transmitters, agents affecting ion channels, cytokines, and approaches to the therapy of AIDS. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780443065743
  • Publisher: Elsevier Health Sciences
  • Publication date: 5/18/2001
  • Edition description: Older Edition
  • Edition number: 4
  • Pages: 856
  • Product dimensions: 7.50 (w) x 9.52 (h) x 1.39 (d)

Table of Contents

Sect. 1 General Principles
1 How drugs act: general principles 2
2 How drugs act: molecular aspects 19
3 Method and measurement in pharmacology 47
4 Absorption and distribution of drugs 61
5 Drug elimination and pharmacokinetics 78
Sect. 2 Chemical Mediators
6 Chemical mediators and the autonomic nervous system 94
7 Cholinergic transmission 110
8 Noradrenergic transmission 139
9 Other peripheral mediators: 5-hydroxytryptamine and purines 164
10 Peptides and proteins as mediators 177
11 Nitric oxide 188
12 Local hormones, inflammation and allergy 198
13 Anti-inflammatory and immunosuppressant drugs 229
Sect. 3 Drugs Affecting Major Organ Systems
14 The heart 250
15 The vascular system 278
16 Atherosclerosis and lipoprotein metabolism 301
17 Hemostasis and thrombosis 310
18 The hemopoietic system 328
19 The respiratory system 338
20 The kidney 351
21 The gastrointestinal system 370
22 The endocrine pancreas and the control of blood glucose 385
23 Obesity 399
24 The pituitary and adrenal cortex 409
25 The thyroid 428
26 The reproductive system 436
27 Bone metabolism 454
Sect. 4 The Central Nervous System
28 Chemical transmission and drug action in the central nervous system 464
29 Amino acid transmitters 470
30 Other transmitters and modulators 483
31 Neurodegenerative disorders 500
32 General anesthetic agents 515
33 Anxiolytic and hypnotic drugs 528
34 Antipsychotic drugs 539
35 Drugs used in affective disorders 550
36 Anti-epileptic drugs and centrally acting muscle relaxants 566
37 Analgesic drugs 579
38 Central nervous system stimulants and psychotomimetic drugs 604
39 Drug dependence and drug abuse 614
40 Local anesthetics and other drugs that affect ion channels 635
Sect. 5 Chemotherapy of Infectious and Malignant Disease
41 Basic principles of chemotherapy 648
42 Cancer chemotherapy 663
43 Antibacterial drugs 686
44 Antiviral drugs 710
45 Antifungal drugs 722
46 Antiprotozoal drugs 727
47 Anthelminthic drugs 742
Sect. 6 General Topics
48 Individual variation and drug Interaction 750
49 Harmful effects of drugs 761
50 Gene therapy 778
App Some Important Pharmacological Agents 787
Index 795
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