Pharmacology / Edition 1

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Overview

Univ. College London, UK. Describes what drugs do and emphasizes the mechanisms by which they act, at the cellular and molecular level. All diagrams have been redrawn, with many new figures added. Concise textbook for medical students.

A concise introduction to the fundamental principles of pharmacology and mechanisms of drug action that focuses on how drugs work--on the cellular and molecular level when possible...features FDA-approved drugs only.

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Editorial Reviews

Booknews
New edition (first in 1987) of a textbook for preclinical medical students and science students, with all sections updated, many new agents included as well as extensions of the basic knowledge which presage further drug development, and new sections on new topics such as 5-HT, peptides as mediators, amino-acid transmitters, agents affecting ion channels, cytokines, and approaches to the therapy of AIDS. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780443075605
  • Publisher: Elsevier Health Sciences
  • Publication date: 3/1/1995
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 855

Table of Contents

Sect. 1 General Principles
1 What is pharmacology? 2
2 How drugs act: general principles 7
3 How drugs act: molecular aspects 22
4 Cellular mechanisms: excitation, contraction and secretion 51
5 Cellular mechanism: cell proliferation and apoptosis 69
6 Method and measurement in pharmacology 80
7 Absorption and distribution of drugs 91
8 Drug elimination and pharmacokinetics 106
Sect. 2 Chemical Mediators
9 Chemical mediators and the autonomic nervous system 122
10 Cholinergic transmission 136
11 Noradrenergic transmission 161
12 Other peripheral mediators: 5-hydroxytrytamine and purines 184
13 Peptides and proteins as mediators 198
14 Nitric oxide 208
15 Local hormones, inflammation and immune reactions 217
16 Anti-inflammatory and immunosuppressant drugs 244
Sect. 3 Drugs Affecting Major Organ Systems
17 The heart 264
18 The vascular system 285
19 Atherosclerosis and lipoprotein metabolism 306
20 Haemostasis and thrombosis 314
21 The haemopoietic system 330
22 The respiratory system 340
23 The kidney 352
24 The gastrointestinal tract 367
25 The endocrine pancreas and the control of blood glucose 380
26 Obesity 394
27 The pituitary and adrenal cortex 404
28 The thyroid 421
29 The reproductive system 429
30 Bone metabolism 446
Sect. 4 The Nervous System
31 Chemical transmission and drug action in the central nervous system 456
32 Amino acid transmitters 462
33 Other transmitters and modulators 474
34 Neurodegenerative disorders 490
35 General anaesthetic agents 503
36 Anxiolytic and hypnotic drugs 515
37 Antipsychotic drugs 525
38 Drugs used in affective disorders 535
39 Antiepileptic drugs 550
40 Analgesic drugs 562
41 CNS stimulants and psychotomimetic drugs 585
42 Drug dependence and drug abuse 594
43 Local anaesthetics 612
Sect. 5 Drugs Used in the Treatment of Infections and Cancer
44 Basic principles of chemotherapy 620
45 Antibacterial drugs 635
46 Antiviral drugs 654
47 Antifungal drugs 666
48 Antiprotozoal drugs 672
49 Anthelminthic drugs 687
50 Cancer chemotherapy 693
Sect. 6 Special Topics
51 Individual variation and drug interaction 712
52 Harmful effects of drugs 724
53 Gene therapy 738
54 Drug discovery and development 747
Appendix 753
Index 761
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