Pharmacology of Alcohol and Alcohol Dependence / Edition 1

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Overview

This is a comprehensive review of the pharmacological effects of alcohol and the mechanisms underlying the pathogenesis of alcoholism. The book draws on general pharmacology, neuropharmacology, and alcohol studies to explore its theme. The second volume in the ALCOHOL AND ALCOHOLISM series, it focuses on the pharmacologic mechanisms underlying the development of alcoholism. The first section on basic pharmacology is concerned with those aspects that are common to all of alcohol's effects. These include pharmacokinetics, general metabolism, and cross-tolerance. The second section on neuropharmacology describes the effects of alcohol on various brain functions, including circulation and metabolism. The third section provides an in-depth review of the neurobiology of physical dependence, withdrawal, and physiological tolerance. The book as a whole gives a comprehensive and authoritative picture of the complex pharmacologic actions of alcohol, particularly on the nervous system. For clinicians and researchers in the field of alcohol and alcoholism, it will serve as a fundamental reference.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Michael Easton, MD (Rush University Medical Center)
Description: This is a detailed review of the pharmacokinetics of alcohol, its neurochemical and neurophysiological effects.
Purpose: The purpose is to add to the present body of information on this topic and add new dimensions to our understanding of the biological mechanisms that may underlie the disease of alcoholism.
Audience: This book is intended for those involved in the basic sciences and those interested in research regarding alcohol's effects from both a biochemical and neurophysiological perspective. It is not particularly useful for clinicians.
Features: It contains an appropriate number of illustrations, tables, and charts. It is well referenced, and the editors and authors are experts in there areas.
Assessment: This is a highly specialized and technical publication with a narrow focus on alcohol kinetics and its biophysiological and neurophysiological effects. It is divided into three parts — alcohol's general pharmacology, the neuropharmacology of alcohol, and finally the neurophysiology of physical dependence, withdrawal, and tolerance. The book reviews known information and brings some new information to light. It is a highly specific but important book intended for individuals involved in this area.
Michael Easton
This is a detailed review of the pharmacokinetics of alcohol, its neurochemical and neurophysiological effects. The purpose is to add to the present body of information on this topic and add new dimensions to our understanding of the biological mechanisms that may underlie the disease of alcoholism. This book is intended for those involved in the basic sciences and those interested in research regarding alcohol's effects from both a biochemical and neurophysiological perspective. It is not particularly useful for clinicians. It contains an appropriate number of illustrations, tables, and charts. It is well referenced, and the editors and authors are experts in there areas. This is a highly specialized and technical publication with a narrow focus on alcohol kinetics and its biophysiological and neurophysiological effects. It is divided into three parts -- alcohol's general pharmacology, the neuropharmacology of alcohol, and finally the neurophysiology of physical dependence, withdrawal, and tolerance. The book reviews known information and brings some new information to light. It is a highly specific but important book intended for individuals involved in this area.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780195100945
  • Publisher: Oxford University Press, USA
  • Publication date: 1/28/1996
  • Series: Alcohol and Alcoholism Series , #2
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 536
  • Product dimensions: 6.40 (w) x 9.30 (h) x 1.50 (d)

Table of Contents

Introduction
1 Pharmacokinetics of Ethanol: Absorption, Distribution, and Elimination 15
2 Metabolism of Ethanol, Acetaldehyde, and Condensation Products 59
3 Cross-Tolerance: Theoretical and Experimental Issues 110
4 Effects of Alcohol on Overall Brain Metabolism 145
5 Effects of Alcohol on Brain Circulation 181
6 Effects of Alcohol on Electrophysiological Activity of the Brain 207
7 Alcohol, Alcoholism, and the Autonomic Nervous System: A Critical Account 248
8 Effects of Alcohol on Membrane Lipids 309
9 Effect of Ethanol on Voltage-Gated Ion Channels 335
10 Effect of Alcohol on Neurotransmitters and Their Receptors and Enzymes 356
11 Pharmacological Effects in the Development of Physiological Tolerance and Physical Dependence 431
12 Neurobiological Substrates for the Anti-Anxiety Effects of Ethanol 477
Index 507
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