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The Pharmacology of Sleep / Edition 1

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Overview

A review of the current state of the clinical and basic science of the pharmacology of sleep. The information provided ranges from a historical perspective to current concepts of sleep mechanisms, including the interaction between pharmacology and sleep-wake regulation and between chronopahrmacology and sleep-wake rhythms. For the first time in one single volume, both the basic mechanisms of sleep, and the basic and clinical aspects of the pharmacology of sleep are dealt with in a thorough, comprehensive and authoritative manner. The chapters, written by the foremost scientific authorities in this field, integrate the latest information on the basic mechanisms of drugs as they relate to their effects on sleep.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Ruzica K. Ristanovic, MD (Rush University Medical Center)
Description: This long-awaited book on pharmacology of sleep incorporates the contributions of a variety of experts (neurologists, psychiatrists, pharmacologists, chronobiologists, and scientists), most from universities in Europe, with some from the U.S.
Purpose: The purpose is to present the state-of-the-art of the pharmacology of sleep. It is organized in three sections: (1) basic mechanisms of sleep and wakefulness; (2) basic pharmacology of neurotransmitters involved in sleep and wakefulness; and (3) clinical applications with a focus on the effects of drugs on sleep. Such a comprehensive review of the pharmacology of sleep enables clinicians to treat sleep disorders, and it also provides neuroscientists with important information. The book meets its overall objective.
Audience: Targeted especially for sleep disorder specialists and neuroscientists involved in sleep research, this book will be useful to other physicians (neurologists, psychiatrists) and fellows specializing in sleep medicine in a variety of settings. Contributors are credible in the subject matter. The editor, also contributor, is a recognized authority in the field.
Features: This book includes a reasonable number of tables and graphs. A rare chapter was underillustrated. The references are extensive and up-to-date. In-depth coverage of specific clinically important topics such as sleep disturbances as side effects of therapeutic drugs is especially useful for practicing physicians.
Assessment: This is a very useful book for sleep disorder specialists, neurologists, psychiatrists, and other physicians as well as neuroscientists involved in sleep research. It combines up-to-date information on fundamental mechanisms of sleep and wakefulness, pharmacology of neurotransmitters involved in regulation of states of vigilance, and clinical pharmacology of sleep (hypnotics, stimulants, other drugs, and sleep). This book fills the void and the educational needs of professionals in the field of sleep medicine and research.
Ruzica K. Ristanovic
This long-awaited book on pharmacology of sleep incorporates the contributions of a variety of experts (neurologists, psychiatrists, pharmacologists, chronobiologists, and scientists), most from universities in Europe, with some from the U.S. The purpose is to present the state-of-the-art of the pharmacology of sleep. It is organized in three sections: (1) basic mechanisms of sleep and wakefulness; (2) basic pharmacology of neurotransmitters involved in sleep and wakefulness; and (3) clinical applications with a focus on the effects of drugs on sleep. Such a comprehensive review of the pharmacology of sleep enables clinicians to treat sleep disorders, and it also provides neuroscientists with important information. The book meets its overall objective. Targeted especially for sleep disorder specialists and neuroscientists involved in sleep research, this book will be useful to other physicians (neurologists, psychiatrists) and fellows specializing in sleep medicine in a variety of settings. Contributors are credible in the subject matter. The editor, also contributor, is a recognized authority in the field. This book includes a reasonable number of tables and graphs. A rare chapter was underillustrated. The references are extensive and up-to-date. In-depth coverage of specific clinically important topics such as sleep disturbances as side effects of therapeutic drugs is especially useful for practicing physicians. This is a very useful book for sleep disorder specialists, neurologists, psychiatrists, and other physicians as well as neuroscientists involved in sleep research. It combines up-to-date information on fundamental mechanisms of sleep and wakefulness, pharmacology ofneurotransmitters involved in regulation of states of vigilance, and clinical pharmacology of sleep (hypnotics, stimulants, other drugs, and sleep). This book fills the void and the educational needs of professionals in the field of sleep medicine and research.

3 Stars from Doody
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Product Details

  • ISBN-13: 9783540589617
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 12/11/1995
  • Series: Handbook of Experimental Pharmacology Series , #116
  • Edition description: 1995
  • Edition number: 1
  • Pages: 583
  • Product dimensions: 1.44 (w) x 6.14 (h) x 9.21 (d)

Table of Contents

Ch. 1 Evolution of Concepts of Mechanisms of Sleep 1
Ch. 2 Principles of Sleep Regulation: Implications for the Effect of Hypnotics on Sleep 29
Ch. 3 Principles of Chronopharmacology and the Sleep-Wake Rhythm 47
Ch. 4 Pharmacology of the Catecholaminergic System 65
Ch. 5 The Serotoninergic System and Sleep-Wakefulness Regulation 91
Ch. 6 Pharmacology of the Histaminergic System 117
Ch. 7 Pharmacology of the Cholinergic System 143
Ch. 8 Pharmacology of the GABAergic/Benzodiazepine System 211
Ch. 9 Pharmacology of the CNS Peptides 243
Ch. 10 Hormones and Sleep 279
Ch. 11 Pharmacology of the Adenosine System 307
Ch. 12 Methodological Issues in Pharmacological Studies of Sleep 323
Ch. 13 Hypnotic Drugs 345
Ch. 14 Anxiolytic Drugs 387
Ch. 15 Stimulant Drugs 421
Ch. 16 Neuroleptics, Antihistamines and Antiparkinsonian Drugs: Effect on Sleep 443
Ch. 17 Antidepressant and Antimanic Drugs 465
Ch. 18 Anticonvulsant Drugs 491
Ch. 19 Mechanisms of Benzodiazepine Drug Dependence 503
Ch. 20 Sleep Disturbances as Side Effects of Therapeutic Drugs 537
Subject Index 569
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