Pharmacology, Physiology, and Practice in Obstetric Anesthesia

by PhD Kaye MD (Editor), DABA Kaye MD (Editor)

Overview

Pharmacology, Physiology, and Practice in Obstetric Anesthesia provides all the essentials of obstetric anesthesia in a straightforward, user-friendly format that avoids encyclopedic language and lengthy discussions, and is inclusive of other healthcare specialties and subspecialties including obstetrics, neonatal care, and more. Coverage spans the essentials of obstetrics as well as overlooked issues including obstetric pharmacology and physiology safe practice strategies, clinical concepts for vaginal delivery and C-section, high-risk pregnancy states and management of the complicated parturient, complications and medicolegal, fetus and newborn considerations, and guidelines, standards and statements related to obstetric anesthesia.Pharmacology, Physiology, and Practice in Obstetric Anesthesia is the perfect reference for an interdisciplinary group of health professionals, policymakers, and researchers working and training in the field of obstetric anesthesiology - Clearly addresses all the aspects of practice within the context of obstetrics, anesthesiology, and neonatal care - Discusses new and relevant topics that are important to the field - Provides up to date information in an accessible, user-friendly format

Product Details

ISBN-13:	9780443217067
Publisher:	Elsevier Science & Technology Books
Publication date:	03/31/2025
Sold by:	Barnes & Noble
Format:	eBook
Pages:	600
File size:	94 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Alan David Kaye, MD, PhD, attended the University of Arizona in Tucson for college and medical school. He also completed his PhD in Vascular Pharmacology at Tulane School of Medicine in New Orleans. Dr. Kaye is the Immediate Former Vice Chancellor of Academic Affairs, Chief Academic Officer, Provost, Pain Fellowship Program Director, and Tenured Professor in the Department of Anesthesiology and Pharmacology, Toxicology, and Neurosciences at Louisiana State University Health Sciences Center in Shreveport. He is also the Vice Chairman of Research and Tenured Professor in the Department of Anesthesiology and Pharmacology, Toxicology, and Neurosciences at the Louisiana State University School of Medicine. He served as Program Director and Chairman of anesthesia for 21 years, for 6 years at Texas Tech Health Sciences Center in Lubbock, Texas, and for 15 years at LSU Health Sciences Center in New Orleans, Louisiana, and was a member of the FDA Advisory Committee on Anesthetics, Analgesics, and Addiction Medicine from 2012 to 2020.
Dr. Aaron Joshua Kaye, MD, graduated from Stanford University in Palo Alto, California, and the Medical University of South Carolina in Charleston, South Carolina. He completed his anesthesia residency at the Medical University of South Carolina in Charleston, South Carolina, and is in private practice with Wake Anesthesiology in Raleigh, North Carolina.

Table of Contents

Contributors About the editors Preface 1. Physiological maternal adaptive changes during pregnancy, e.g., alterations of endometrium and decidua, menstruation, placenta, fetal membranes, placental hormones, morphological and functional fetal developmentAmber N. Edinoff, Brooke Williams, Layne Landry, Elyse M. Cornett and Alan David Kaye1. Introduction 2. Estrogen and progesterone in pregnancy 2.1 Progesterone 2.2 Estrogen 2.3 Decidualization 3. Physical changes in pregnancy 3.1 Cardiovascular system 3.2 GI system 3.3 Respiratory system 3.4 Skin 3.5 Sensory 3.6 Hematology 4. Pharmacologic changes in pregnancy 4.1 Absorption 4.2 Distribution 4.3 Metabolism 4.4 Elimination 5. Issues arising from the physiologic changes of pregnancy 5.1 Hypertensive disorders of pregnancy 5.2 Peripartum cardiomyopathy 5.3 Pulmonary changes in pregnancy 5.4 Postpartum depression 6. ConclusionReferences2. Anatomy of the reproductive tract: The placenta, uteroplacental circulation, anatomy, transfer of drugs, and respiratory gas exchangeJessica Galey, Amy Zheng and Shobana Bharadwaj1. Anatomy of the female reproductive tract1.1 Organs1.2 Innervation 1.3 Blood flow1.4 Uterine blood flow changes during pregnancy 2. Anatomy of the placenta2.1 Embryology2.2 Macroscopic anatomy2.3 Maternal vasculature2.4 Fetoplacental vasculature3. Placental physiology3.1 Oxygen transfer3.2 Carbon dioxide transfer 3.3 Acid base3.4 Placental drug transfer3.5 Common drugs used during pregnancy3.6 Anesthetic drugs and placental transfer4. Conclusion3. Uterine blood flow and the effects of obstetric anesthesiaJohn Pallan, Amy Zheng, Jessica Galey and Shobana Bharadwaj1. Introduction2. Anatomy3. Uteroplacental blood flow4. Response to vasoactive agents5. Mechanisms of changes6. Determinants of uterine blood flow7. Measuring uterine blood flow8. Regional anesthesia and uterine blood flow9. Doppler ultrasonography and uterine blood flow10. General anesthesia and uterine blood flow11. Effects of obstetric drugs12. Conclusion4. Perinatal pharmacologyRucha Kelkar, Alina Smoleva, Therese Larson, Sahar Shekoohi and Alan David Kaye1. Definition, background2. Maternal factors3. Placental factors4. Basic fetal pathophysiology and risk factors5. Fetal drug uptake, distribution, metabolism, and excretion6. Related issues, historical trendsReferences5. Parturient anesthesia assessment and evaluationHrayr Ghazaryan, Artush Grigoryan and Lincoln Frederick Arbogast1. Introduction2. History of anesthesia in obstetrics3. Physiological changes in pregnancy3.1 Cardiovascular3.2 Respiratory3.3 Gastrointestinal3.4 Urinary3.5 Endocrine3.6 Hematologic 3.7 Coagulation4. Preanesthesia evaluation of parturients4.1 Past surgical history and anesthetic history4.2 Past obstetric history4.3 Past medical history4.4 Physical examination5. Evaluation of parturient with systemic disease5.1 Cardiovascular diseases 5.2 Respiratory diseases 5.3 Anemias 5.4 Coagulation disorders 6. Endocrine diseases 6.1 Diabetes mellitus 6.2 Hyperthyroidism 6.3 Musculoskeletal disorders 6.4 Renal diseases6.5 Liver diseases7. Conclusion References6. How to create and maintain a safe and an efficient obstetric anesthesia practiceAnjum Anwar, Huma Wali and Hina Shamim1. Introduction2. Maternal care framework in the United States3. Preanesthesia evaluation for obstetric patients 3.1 Background 4. Current state of affairs and challenges 4.1 Recommendations 5. Telemedicine 6. Patient education 7. Intrapartum care for parturient 7.1 Introduction 8. Challenges and recommendations 8.1 Medication shortages 8.2 Staffing and training/anesthesia workforce 8.3 Recommendations 8.4 Anesthesia management of high-risk pregnancies 8.5 Peripartum obstetric hemorrhage 8.6 Concept of the pregnancy heart team and cardiac obstetrics 8.7 Critical care in obstetrics 9. Enhanced recovery after CD 10. Process improvement to enhance patient safety in obstetric anesthesia 11. Handoffs and checklists 12. Simulation and team working in obstetric anesthesia 13.