Pharmacology: Drug Actions and Reactions, 5th Edition / Edition 5

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Overview

This is a revised and updated edition of Dr. Levine's classic textbook on basic pharmacological principles and the general concepts of chemical-biological interactions with the human body. Originally written for students majoring in sciences and the humanities, it has been widely accepted by pharmacology students, medical students, pharmacy students, graduate nurses, veterinary students and other allied health students.

The book contains both black-and-white and two-color illustrations.

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Editorial Reviews

Eric M. Scholar
This sixth edition is a description of the science of pharmacology. It has been revised and updated from the previous edition. The purpose is to present a comprehensive and coherent explanation of the science of pharmacology in terms of basic concepts and general principles. This book is designed for pharmacology students, medical students, pharmacy students, graduate nurses, veterinary students, and other allied health students. The editor is well qualified to write this book. The editor has made this a collaborative effort to reaffirm and strengthen the original concept and incorporates the knowledge and experience of Drs. Carol Walsh and Schwartz-Bloom, two long-time teachers of pharmacology. The major portion of the book is composed of chapters on the general principles of pharmacology. Most of these sections are traditionally considered as part of pharmacokinetics and include topics such as drug absorption, excretion, and biotransformation. There are also chapters on drug toxicity, drug abuse and dependence, and the development and evaluation of new drugs. At the end of each chapter is a series of study guides and reviews in question format as well as a list of suggested reading. Many of the concepts are clearly illustrated with helpful and informative figures. There are eight appendixes at the end of the book and each contains a summary of the pharmacology of an individual drug class. This book is an excellent description of the general principles of pharmacology. Unfortunately the editor and contributors fail to provide much information on receptors and receptor signaling. However, I feel the biggest drawback is the lack of information on the pharmacology of most ofthe major drug classes with the individual drug classes being only briefly covered in the appendixes. As a result, this book is most useful as an adjunct textbook for most pharmacology courses and not as the only textbook.
From The Critics
Reviewer: Eric M. Scholar, PhD (University of Nebraska Medical Center)
Description: This sixth edition is a description of the science of pharmacology. It has been revised and updated from the previous edition.
Purpose: The purpose is to present a comprehensive and coherent explanation of the science of pharmacology in terms of basic concepts and general principles.
Audience: This book is designed for pharmacology students, medical students, pharmacy students, graduate nurses, veterinary students, and other allied health students. The editor is well qualified to write this book.
Features: The editor has made this a collaborative effort to reaffirm and strengthen the original concept and incorporates the knowledge and experience of Drs. Carol Walsh and Schwartz-Bloom, two long-time teachers of pharmacology. The major portion of the book is composed of chapters on the general principles of pharmacology. Most of these sections are traditionally considered as part of pharmacokinetics and include topics such as drug absorption, excretion, and biotransformation. There are also chapters on drug toxicity, drug abuse and dependence, and the development and evaluation of new drugs. At the end of each chapter is a series of study guides and reviews in question format as well as a list of suggested reading. Many of the concepts are clearly illustrated with helpful and informative figures. There are eight appendixes at the end of the book and each contains a summary of the pharmacology of an individual drug class.
Assessment: This book is an excellent description of the general principles of pharmacology. Unfortunately the editor and contributors fail to provide much information on receptors and receptor signaling. However, I feel the biggest drawback is the lack of information on the pharmacology of most of the major drug classes with the individual drug classes being only briefly covered in the appendixes. As a result, this book is most useful as an adjunct textbook for most pharmacology courses and not as the only textbook.
Booknews
This update of the 1996 edition<-->used in teaching pharmacology at Boston U. (evidently where the author is based) and Duke U. <-->incorporates current understanding of vital processes and their interactions with exogenous substances (including caffeine but not herbal medicines). Substantially revised are the chapters on environmental and occupational toxicology and drug design and development. Appendices cover drugs affecting various bodily systems and disorders, and weights and measures. Includes two- color illustrations, and the foreword and preface to the now classic first edition published circa 1980. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9781850707806
  • Publisher: Informa Healthcare
  • Publication date: 1/28/1996
  • Edition description: Older Edition
  • Edition number: 5
  • Pages: 569

Table of Contents

Foreword to the First Edition
Preface to the Sixth Edition
Preface to the First Edition
1 The Heritage of Pharmacology 1
2 The Scope of Pharmacology 17
3 How Drugs Act on the Living Organism 27
4 How Drugs Reach their Site of Action: I. General Principles of Passage of Drugs Across Biologic Barriers 51
5 How Drugs Reach their Site of Action: II. Absorption 75
6 How Drugs Reach their Site of Action: III. Distribution 107
7 How the Actions of Drugs are Terminated: I. Excretion 123
8 How the Actions of Drugs are Terminated: II. Biotransformation 151
9 General Principles of the Quantitative Aspects of Drug Action: I. Dose-Response Relationships 181
10 General Principles of the Quantitative Aspects of Drug Action: II. Time-Response Relationships 219
11 Factors Modifying the Effects of Drugs in Individuals: I. Variability in Response Attributable to the Biologic System 259
12 Factors Modifying the Effects of Drugs in Individuals: II. Variability in Response Attributable to the Conditions of Administration 287
13 Drug Toxicity 323
14 How Drugs Alter Physiologic Function: A Recapitulation 367
15 The Pharmacologic Aspects of Drug Abuse and Drug Dependence 389
16 The Development and Evaluation of New Drugs 425
Glossary 453
App. 1 Drugs Affecting the Gastrointestinal Tract 475
App. 2 Drugs Influencing Renal Function 485
App. 3 Chemotherapy 491
App. 4 Drugs Used to Alter the Perception of and Response to Pain 503
App. 5 Sedatives and Hypnotics 521
App. 6 Drugs Used in the Treatment of Psychiatric Disorders 527
App. 7 Central Nervous System Stimulants 535
App. 8 Weights and Measures 541
Index 545
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