Pharmacometrics: The Science of Quantitative Pharmacology / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $168.60
Usually ships in 1-2 business days
(Save 29%)
Other sellers (Hardcover)
  • All (9) from $168.60   
  • New (7) from $190.18   
  • Used (2) from $168.60   


This book lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy; providing a comprehensive set of tools for the training and development of pharmacometricians. With key updates, the new edition includes new ideas and concepts while at the same time containing ideas that provide a window into the ever-expanding frontier of pharmacometrics and its continued impact on drug development, regulation, and evaluation. In particular, model-based meta-analysis and modeling unusual data is expanded as these approaches have become much more widely used and warrant detailed treatment. A companion website contains pattern for writing codes and appendices featuring pointers to codes.
Read More Show Less

Editorial Reviews

From the Publisher
"…this landmark text is the first to pull together and present in one volume the many facets of pharmacometrics." (American Journal of Pharmaceutical Education, Vol 71, No. 4, 2007)
Read More Show Less

Product Details

  • ISBN-13: 9780471677833
  • Publisher: Wiley
  • Publication date: 2/16/2007
  • Edition number: 1
  • Pages: 1216
  • Product dimensions: 7.34 (w) x 10.04 (h) x 2.74 (d)

Meet the Author

ENE I. ETTE, PhD, is a Fellow of the American Colleges of Clinical Pharmacy and Clinical Pharmacology. He is the President/CEO of Anoixis Corp. and was formerly the senior director and head of clinical pharmacology at Vertex Pharmaceuticals, Inc. He is also an adjunct professor of applied pharmaceutical sciences at the University of Rhode Island. Dr. Ette was a pioneer pharmacometric staff in the Office of Clinical Pharmacology and Biopharmaceutics at the Food and Drug Administration, where he developed the popular reference Guidance for Industry: Population Pharmacokinetics. From 1989 –2001, he was an FDA Consultant. In recognition of his contributions to clinical pharmacy and clinical pharmacology, Dr. Ette is the recipient of The American College of Clinical Pharmacy's Russell Miller Award. He is also the 2006 recipient of The American College of Clinical Pharmacy's Therapeutic Frontiers Lecture Award. Dr. Ette is chairman of the pharmacometrics panel of The Annals of Pharmacotherapy editorial board.

PAUL J. WILLIAMS, PharmD, is a Fellow of the American Colleges of Clinical Pharmacy and Clinical Pharmacology and Professor of Pharmaceutical Sciences and Pharmacy Practice at the Thomas J. Long School of Pharmacy and Health Sciences. Dr. Williams is the Vice President, Strategic Consulting, West Coast Operations in Anoixis Corp. and was formerly a partner at Trials by Design, LLC, a clinical consulting company, and member of the editorial board for The Annals of Pharmacotherapy. Dr. Williams is the 2006 winner of the University of the Pacific Faculty Research Award, the Long's Faculty Fellowship, and Teacher of the Year.

Read More Show Less

Table of Contents





Chapter 1. Pharmacometrics: Impacting Drug Development and Pharmacotherpay.


Chapter 2. General Principles of Programming (Computer and Statistical).

Chapter 3. Validation of Software for Pharmacometric Analyses.

Chapter 4. Linear, Generalized Linear, and Nonlinear Mixed-Effects Models.

Chapter 5. Bayesian Hierarchical Modeling with Markov Chain Monte Carlo Methods.

Chapter 6. Estimating the Dynamics of Drug Regimen Compliance.

Chapter 7. Graphical Display for Modeling Population Data.

Chapter 8. The Epistemology of Pharmacometrics.

Chapter 9. Data Imputation.


Chapter 10. Population Pharmacokinetic Estimation Methods.

Chapter 11. Timing and Efficiency in Population Pharmacokinetic / Pharmacodynamic Data Analysis.

Chapter 12. Designing Population Pharmacokinetic Studies for Efficient Parameter Estimation.

Chapter 13. Population Models for Drug Absorption and Entero-hepatic Recycling.

Chapter 14. Pharmacometric Knowledge Discovery from Clinical trial Data Sets.

Chapter 15. Resampling Techniques and Their Application to Pharmacometrics.

Chapter 16. The Population Approach to Bioequivalence.


Chapter 17. Biomarkers in Drug Development and Pharmacometric Modeling.

Chapter 18. Analysis of Gene Expression Data.

Chapter 19. Pharmacogenomics and Pharmacokinetic/Pharmacodynamic Modeling.

Chapter 20. Empirical Pharmacokinetic/Pharmacodynamic Models.

Chapter 21. Developing Models of Disease Progression.

Chapter 22. Mechanistic Pharmacokinetic/Pharmacodynamic (PK/PD) Models.

Chapter 23. Mechanistic Pharmacokinetic/Pharmacodynamic Models II.

Chapter 24. PK/PD Analysis of Binary (Logistic) Outcome Data.

Chapter 25. Population Pharmacokinetic / Pharmacodynamic Modeling of Ordered Categorical Longitudinal Data.

Chapter 26. Transition Models in Pharmacodynamics.

Chapter 27. Mixed Effects Modeling of Count Data.

Chapter 28. Mixture Modeling with NONMEM.


Chapter 29. Designs for First Time-in-Man Studies in Non-Oncology Indications.

Chapter 30. Design for Phase I Studies in Oncology.

Chapter 31. Design and Analysis of Clinical Exposure - Response Trials.


Chapter 32. Pharmacometric Knowledge Creation: Towards Characterizing an Unexplored Region of the Response Surface.

Chapter 33. Clinical Trial Simulation: Theory.

Chapter 34. Modeling and Simulation: Planning and Execution.

Chapter 35. Clinical Trial Simulation: Efficacy Trials.


Chapter 36. Engineering a Pharmacometrics Enterprise.

Chapter 37. Communication of Pharmacometric Analysis Outcome.


Chapter 38. Pharmacometrics Applications in Population  Exposure-Response Data for New Drug Development and Evaluation.

Chapter 39. Pharmacometrics in Pharmacotherapy and Drug Development: Pediatric Application.

Chapter 40. Pharmacometric Methods for Assessing Drug-Induced QT and QTc Prolongations for Non-Antiarrhythmic Drugs.

Chapter 41. Using Pharmacometrics in the Development of Biologic Therapeutic Agents.

Chapter 42. Analysis of Quantic Pharmacokinetic Study: Robust Estimation of Tissue-to-Plasma Ratio.

Chapter 43. Physiologically Based Pharmacokinetic Modeling: Inhalation, Ingestion and Dermal Absorption.

Chapter 44. Modeling of Metablite Pharmacokinetics in a Large Pharmacokinetic Data Set: An Application.

Chapter 45. Characterizing Nonlinear Pharmacokinetics: An Example Scenario for a Therapeutic Protein.

Chapter 46. Development, Evaluation and Applications of In Vitro/ In Vivo Correlations: A Regulatory Perspective.

Chapter 47. The Confluence of Pharmacometric Knowledge Discovery and Creation in the Characterization of Drug Safety.

Read More Show Less

Customer Reviews

Average Rating 5
( 1 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously
Sort by: Showing 1 Customer Reviews
  • Posted September 12, 2009

    Excellent, it's worth every penny paid for the Text book

    An excellent book who wants to learn quantitative pharmacology. it is a book to keep for a lifetime.

    Was this review helpful? Yes  No   Report this review
Sort by: Showing 1 Customer Reviews

If you find inappropriate content, please report it to Barnes & Noble
Why is this product inappropriate?
Comments (optional)