Pharmacotherapy: A Pathophysiologic Approach, Eighth Edition [NOOK Book]


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Pharmacotherapy: A Pathophysiologic Approach, Eighth Edition

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The most comprehensive, widely used, and evidence-based pharmacotherapy text available

Full-color design!

A Doody's Core Title ESSENTIAL PURCHASE for 2011!


"This is a gold standard reference in pharmacy and the information it provides equips readers with the knowledge base and confidence to provide the highest quality of patient care."--Doody's Review Service

Hailed by Doody's Review Service as "one of the best in pharmacy" Pharmacotherapy: A Pathophysiologic Approach is unmatched in its ability to help students develop a mastery of evidence-based medicine for optimum patient outcomes. The eighth edition will feature the addition of SI units throughout and an increased number of global examples and clinical questions.


  • Unparalleled guidance in the development of pharmaceutical care plans

  • Full-color presentation

  • Key Concepts in each chapter

  • Critical Presentation boxes summarize common disease signs and symptoms

  • Clinical Controversies boxes examin complicated issues you face when providing drug therapy

  • NEW material added to the online learning center

  • EXPANDED evidence-based recommendations

  • EXPANDED coverage of timely issues such as palliative care and pain medicine

  • Therapeutic recommendations in each disease-specific chapter

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Editorial Reviews

From The Critics
Reviewer: Melissa M. Ranieri, BS, PharmD (Temple University School of Pharmacy)
Description: This is the eighth edition of a comprehensive reference dedicated to providing the latest information on the pathophysiology and therapeutic management of a range of disease states. Information is evidence-based, current, and outlined in a way that emphasizes key points and can be applied in clinical practice.
Purpose: The editors are renowned, well-established experts in the field of pharmacy who are dedicated to providing information that is complete and reflective of the latest guidelines and practice standards. They accomplish this goal yet again with this new edition. A multitude of authors, all experts in their respective fields, have contributed chapters.
Audience: This is versatile reference that can be used by pharmacists, pharmacy students, instructors, and other healthcare practitioners who are seeking the latest and most comprehensive information on disease state pathophysiology and management. Summarized concepts in tables and flow algorithms make information easily accessible and ready to be applied in practice. As with any reference, the one caveat is that the most current information cannot always be provided since guidelines and evidence-based medicine are constantly changing. However, the authors make every effort to be current and in accord with practice standards.
Features: This edition adds six new chapters and covers a wide variety of disease states. Novel topics reflect the evolving practice of medicine and include palliative care, health literacy, cultural competency and medication safety. Learning strategies that emphasize important concepts are used throughout. Each section opens with key concepts, which highlight the most critical information. Charts and flow algorithms present information in a way that can be easily referenced and applied in clinical practice. For example, the osteoporosis chapter covers dosing, adverse effects, and drug interactions clearly outlined in table format. The osteoporosis treatment algorithm clearly denotes which therapies are first-line and when in the course of the disease to institute preventive measures, as well as treatment modalities. A section in each chapter of clinical controversies highlights topics that are currently being debated in practice. These topics are well chosen, are clinically relevant, and include how healthcare practitioners are handling these issues in practice. Finally, the book is well referenced with over 100 references for each chapter, which directs readers to further information if needed. As a clinical assistant professor of pharmacy, I find the book clearly written, as well as thorough and current. However, students sometimes describe the information as dense, and the authors have addressed this concern by summarizing topics more succinctly than in previous editions. I think they have succeeded, and the change is noticeable when perusing topics and it will help students and newer practitioners grasp important concepts more easily.
Assessment: This is a gold standard reference in pharmacy and the information it provides equips readers with the knowledge base and confidence to provide the highest quality of patient care.
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Product Details

  • ISBN-13: 9780071784993
  • Publisher: McGraw-Hill Education
  • Publication date: 4/4/2011
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 8
  • Pages: 2700
  • File size: 179 MB
  • Note: This product may take a few minutes to download.

Meet the Author

Author Profiles

Joseph DiPiro, PharmD, FCCP

Executive Dean and Professor,

South Carolina School of Pharmacy

Robert Talbert, PharmD, FCCP, BCPS


University of Texas, Health Science Center

Gary Yee, PharmD, FCCP

Professor and Associate Dean for Academic Affairs

University of Nebraska, Medical Center

Gary Matzke, PharmD, FCP, FCCP

Professor and Associate Dean for Clinical Research and Public Policy

Virginia Commonwealth University School of Clinical Research and Public Policy

Barbara Wells, PharmD, FASHP, FCCP, BCPP

Dean and Professor, Executive Director of the Research Institute of Phamaceutical Sciences

University of Mississippi School of Pharmacy

L. Michael Posey, BS Pharm

Editorial Director

American Pharmacists Association

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Table of Contents

Section 1: Foundation Issues Section Editor: L. Michael Posey

1. Pharmacoeconomics: Principles, Methods, and Applications

2. Health Outcomes and Quality of Life

3. Health Literacy and Medication Use

4. Cultural Competency

5. Principles and Practices of Medication Safety

6. Evidence Based Medicine

7. Documentation of Pharmacy Services

8. Clinical Pharmacokinetics and Pharmacodynamics

9. Pharmacogenetics

10. Pediatrics

11. Geriatrics

12. Palliative Care

13. Pharmacoepidemiology

14. Clinical Toxicology

15. Emergency Preparedness: Identification and Management of Biologic Exposures

16. Emergency Preparedness: Identification adn Management of Chemical and Radiologic Exposures

Section 2: Cardiovascular Disorders Section Editor: Robert L. Talbert

17. Cardiovascular Testing

18. Cardiac Arrest

19. Hypertension

20. Systolic Heart Failure

21. Diastolic Heart Failure and the Cardiomyopathies

22. Acute Decompensated Heart

23. Ischemic Heart DiseaseJ

24. Acute Coronary Syndromes

25. The Arrhythmias

26. Venous Thromboembolism

27. Stroke

28. Dyslipidemia

29. Peripheral Arterial Disease

30. Use of Vasopressors and Inotropes in the Pharmacotherapy of Shock

31. Hypovolemic Shock

Section 3: Respiratory Disorders Section Editor: Robert L. Talbert

32. Introduction to Pulmonary Function Testing

33. Asthma

34. Chronic Obstructive Pulmonary Disease

35. Pulmonary Hypertension

36. Drug-Induced Pulmonary Diseases

37. Cystic Fibrosis

Section 4: Gastrointestinal Disorders Section Editor: Joseph T. DiPiro

38. Evaluation of the Gastrointestinal Tract

39. Gastroesophageal Reflux Disease

40. Peptic Ulcer Disease

41. Inflammatory Bowel Disease

42. Nausea and Vomiting

43. Diarrhea, Constipation, and Irritable Bowel Syndrome

44. Portal Hypertension and Cirrhosis

45. Drug-Induced Liver Disease

46. Pancreatitis

47. Viral Hepatitis

48. Drug Therapy Individualization in Patients with Hepatic Disease or Genetic Alterations in Drug Metabolizing Activity

49. Celiac Disease

Section 5: Renal Disorders Section Editor: Gary R. Matzke

50. Clinical Assessment of Kidney Function

51. Acute Kidney Injury

52. Chronic Kidney Disease: Progression-Modifying Therapies

53. Chronic Kidney Disease: Management of Complications

54. Hemodialysis and Peritoneal Dialysis

55. Drug-Induced Kidney Disease

56. Glomerulonephritis

57. Drug Therapy Individualization for Patients with Renal Insufficiency

58. Disorders of Sodium and Water Homeostasis

59. Disorders of Calcium and Phosphorus Homeostasis

60. Disorders of Potassium and Magnesium Homeostasis Donald F. Brophy and Todd W. B. Gehr

61. Acid-Base Disorders

Section 6: Neurologic Disorders Section Editor: Barbara G. Wells

62. Evaluation of Neurologic Illness

63. Alheimer's Disease

64. Multiple Sclerosis

65. Epilepsy

66. Status Epilepticus

67. Acute Management of the Brain Injury Patient

68. Parkinson's Disease

69. Pain Management

70. Headache Disorders

Section 7: Psychiatric Disorders Section Editor: Barbara G. Wells

71. Evaluation of Psychiatric Illness

72. Childhood Disorders

73. Eating Disorders

74. Substance Related Disroders: Overview and Depressahts, Stimulants and Hallucinogens

75. Substance-Related Disorders: Alcohol, Nicotine, and Caffeine

76. Schizophrenia

77. Major Depressive Disorders

78. Bipolar Disorder

79. Anxiety Disorders I: Generalized Anxiety, Panic, and Social Anxiety Disorders

80. Anxiety Disorders II: Posttraumatic Stress Disorder and Obsessive-Compulsive Disorder

81. Sleep Disorders

82. Disorders Associated with Intellectual Disabilities

Section 8: Endocrinologic Disorders Section Editor: Robert L. Talbert

83. Diabetes Mellitus

84. Thyroid Disorders

85. Adrenal Gland Disorders

86. Pituitary Gland Disorders

Section 9: Gynecologic and Obstetric Disorders Section Editor: Barbara G. Wells

87. Pregnancy and Lactation: Therapeutic Considerations

88. Contraception

89. Menstruation-Related Disorders

90. Endometriosis

91. Hormone Terapy in Women

Section 10: Urologic Disorders Section Editor: L. Michael Posey

92. Erectile Dysfunction

93. Benign Prostatic Hyperplasia

94. Urinary Incontinence

Section 11: Immunologic Disorders Section Editor: Gary C. Yee

95. Function and Evaluation of the Immune System

96. Systemic Lupus Erythematosus and Other Collagen-Vascular Diseases

97. Allergic and Pseudoallergic Drug Reactions

98. Solid-Organ Transplantation

Section 12: Rheumatologic Disorders Section Editor: L. Michael Posey

99 Osteoporosis and Other Metabolic Bone Diseases

100. Rheumatoid Arthritis

101. Osteoarthritis

102. Gout and Hyperuricemia

Section 13: Ophthalmic and Otolaryngological Disorders Section Editor: L. Michael Posey

103. Glaucoma

104. Allergic Rhinitis

Section 14: Dermatologic Disorders Section Editor: L. Michael Posey

105 Dermatologic Drug Reactions and Common Skin Conditions

106. Acne Vulgaris

107. Psoriasis

108. Atopic Dermatitis

Section 15: Hematologic Disorders Section Editor: Gary C. Yee

109. Anemias

110. Coagulation Disorders

111. Sickle Cell Disease

112. Drug-Induced Hematologic Disorders

Section 16: Infectious Diseases Section Editor: Joseph T. DiPiro

113. Laboratory Tests to Direct Antimicrobial Pharmacotherapy

114. Antimicrobial Regimen Selection

115. Central Nervous System Infections

116. Lower Respiratory Tract Infections

117. Upper Respiratory Tract Infections

118. Influenza

119. Skin and Soft Tissue Infections

120. Infective Endocarditis

121. Tuberculosis

122. Gastrointestinal Infections and Enterotoxigenic Poisonings

123. Intraabdominal Infections

124. Parasitic Diseases

125. Urinary Tract Infections and Prostatitis

126. Sexually Transmitted Diseases

127. Bone and Joint Infections

128. Sepsis and Septic Shock

129. Superficial Fungal Infections

130. Invasive Fungal Infections

131. Infections in Immunocompromised Patients

132. Antimicrobial Prophylaxis in Surgery

133. Vaccines, Toxoids, and Other Immunobiologics

134. Human Immunodeficiency Virus Infection

Section 17: Oncologic Disorders Section Editor: Gary C. Yee

135. Cancer Treatment and Chemotherapy

136. Breast Cancer

137. Lung Cancer

138. Colorectal Cancer

139. Prostate Cancer

140. Lymphomas

141. Ovarian Cancer

142. Acute Leukemias

143. Chronic Leukemias

144. Multiple Myeloma

145. Myelodysplastic Syndromes (Web-only)

146. Skin Cancer

147. Melanoma

148. Hematopoietic Stem Cell Transplantation

Section 18: Nutritional Disorders Section Editor: Gary R. Matzke

149. Assessment of Nutrition Status and Nutrition Requirements

150. Medication Administration Considerations With Specialized Nutrition Support

151. Parenteral Nutrition

152. Enteral Nutrition

153. Nutritional Considerations in Major Organ Failure

154. Obesity



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