Pharmacotherapy: A Pathophysiologic Approach / Edition 3

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* Comprehensive: acclaimed in a prior edition as “the best pharmacotherapy textbook available,”* it offers you the most detailed pathophysiologic approach to selecting and using pharmaceutical agents in disease management and pharmaceutical care
* Current: the 5th Edition presents the latest information on new drugs and new approaches to treatment and disease management in all therapy sections
* New Chapters: now covers evidence-based medicine, pharmacogenetics, benign prostatic hyperplasia, endometriosis, erectile dysfunction, urinary incontinence, and much more
* Disease Management Focus: meets the needs of pharmacy curriculum and establishes a strong pathophysiologic basis for treatment
* Student-Friendly: provides clear explanations on how a particular organ system and related drug therapy is evaluated; includes dozens of treatment algorithms, figures and tables for quick readability; also offers the necessary background to understand topics including pharmacoeconomics and the used of evidence-based decision-making in practice
*Annals of Pharmacotherapy on the 4th Edition

The book contains color illustrations.

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Editorial Reviews

The present edition contains 132 chapters contributed by educators and practitioners affiliated with various college and university pharmacy departments. The overall organization of previous editions is retained, as is the emphasis on understanding disease mechanisms and principles of therapy. New chapters have been added on disorders of the pituitary gland and substance-related disorders, and treatment sections in each chapter are now boxed, making them easier to locate. The first seven chapters cover fundamentals, such as pharmacoeconomics, pharmacoepidemiology, pharmacokinetics, drug interactions, and clinical toxicology. Most of the remaining chapters focus on the epidemiology, pathophysicology, clinical presentation, desired outcomes, treatment, and treatment evaluation of specific disease states. Annotation c. Book News, Inc., Portland, OR (
Doody's Review Service
Reviewer: Joan Stachnik, PharmD, BCPS (University of Illinois at Chicago College of Pharmacy)
Description: This is the fifth edition of a book on treatment of major disease states, with an emphasis on medication selection based on the pathophysiology of the disorder. It is an update of the 1999 edition.
Purpose: The purpose of the book is to provide healthcare professionals, primarily pharmacists, and students with a pathophysiologic basis for medication selection. The authors recognize the important role of pharmacists in assuring that patients receive appropriate and optimal drug therapy. This role can only be fulfilled if the practicing clinician has a strong foundation in pathophysiology and pharmacotherapy. Given the complexity of disease state management and continual advances in pharmacotherapy, this is a necessary book. As with previous editions, the authors exceed the book's objectives.
Audience: This book is written for practicing clinicians, primarily pharmacists, who are responsible for recommending or managing a patient's drug therapy. It is also written for students, to provide them with a strong foundation in these areas. The authors of each chapter are selected for their expertise in various areas. The editors are all recognized educators and clinicians.
Features: The book covers the basic concepts of pharmacotherapy as well as major disease states. Each chapter includes a review of the epidemiology, etiology, pathophysiology, clinical presentation, and treatment of major disease states. Although new information has been added, the format of each chapter remains consistent with previous editions. This makes the book familiar to long-time users, and easy to use for students. Several new chapters have been added. Graphs, illustrations, and tables are used frequently to illustrate major concepts.
Assessment: This is likely one of the most well-established references in use by practicing pharmacist-clinicians and students. It is more comprehensive than other similar books and has expanded its content since first published in 1988. This new edition continues to provide valuable information for the pharmacotherapeutic management of disease states.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780838578926
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 8/28/1996
  • Edition description: Older Edition
  • Edition number: 3
  • Pages: 2885
  • Product dimensions: 8.72 (w) x 11.24 (h) x 3.47 (d)

Meet the Author

Dipiro, Joseph T., PharmD(Univ of Georgia)

Talbert, Robert L., PharmD(Univ of Texas) Yee, Gary C., PharmD(Univ of Nebraska)

Matzke, Gary R., PharmD(Univ of Pittsburgh)

Wells, Barbara G., PharmD(Idaho State Univ)

Posey, L. Michael, RPh(Pharmacy Editorial & News Services)

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Table of Contents

Guiding Principles of Pharmacotherapy
Sect. 1 Basic Concepts
1 Pharmacoeconomics: Principles
2 Health Outcomes and Quality of Life
3 Clinical Pharmacokinetics and Pharmacodynamics
4 Pediatrics
5 Geriatrics
6 Pharmacoepidemiology
7 Clinical Toxicology
Sect. 2 Cardiovascular Disorders
8 Cardiovascular Testing
9 Cardiopulmonary Resuscitation
10 Hypertension
11 Heart Failure
12 Ischemic Heart Disease
13 Myocardial Infarction
14 Arrhythmias
15 Cardiomyopathies
16 Cardiac Transplantation
17 Thromboembolic Disorders
18 Stroke
19 Hyperlipidemia
20 Peripheral Vascular Disease
21 Use of Vasopressors and Inotropes in the Pharmacotherapy of Shock
22 Hypovolemic Shock
Sect. 3 Respiratory Disorders
23 Pulmonary Function Testing
24 Asthma
25 Chronic Obstructive Lung Disease
26 Respiratory Distress Syndrome
27 Drug-Induced Pulmonary Diseases
28 Cystic Fibrosis
Sect. 4 Gastrointestinal Disorders
29 Evaluation of the Gastrointestinal Tract
30 Gastroesophageal Reflux Disease
31 Peptic Ulcer Disease
32 Inflammatory Bowel Disease
33 Nausea and Vomiting
34 Diarrhea and Constipation
35 Portal Hypertension and Cirrhosis
36 Drug-Induced Liver Disease
37 Pancreatitis
38 Viral Hepatitis
39 Liver Transplantation
Sect. 5 Renal Disorders
40 Assessment of Renal Function
41 Acute Renal Failure
42 Chronic Renal Insufficiency and End-Stage Renal Disease
43 Renal Transplantation
44 Hemodialysis and Peritoneal Dialysis
45 Drug-Induced Renal Disease
46 Glomerulonephritis
47 Drug Therapy Individualization for Patients with Renal Insufficiency
48 Electrolyte Homeostasis
49 Acid-Base Disorders
Sect. 6 Neurologic Disorders
50 Evaluation of Neurologic Illness
51 Multiple Sclerosis
52 Epilepsy
53 Status Epilepticus
54 Acute Management of the Head Injury Patient
55 Parkinson's Disease
56 Pain Management
57 Headache Disorders: Migraine and Cluster
Sect. 7 Psychiatric Disorders
58 Evaluation of Psychiatric Illness
59 Childhood Disorders
60 Eating Disorders
61 Alzheimer's Disease
62 Substance-Related Disorders: Overview and Depressants, Stimulants, and Hallucinogens
63 Substance-Related Disorders: Alcohol, Nicotine, and Caffeine
64 Schizophrenia
65 Depressive Disorders
66 Bipolar Disorder
67 Anxiety Disorders
68 Obsessive-Compulsive Disorder
69 Sleep Disorders
Sect. 8 Endocrinologic Disorders
70 Diabetes Mellitus
71 Thyroid Disorders
72 Adrenal Gland Disorders
73 Pituitary Gland Disorders
Sect. 9 Gynecologic and Obstetric Disorders
74 Pregnancy and Lactation: Therapeutic Considerations
75 Infertility
76 Contraception
77 Menstrual-Related Disorders
78 Hormone Replacement Therapy
Sect. 10 Immunologic Disorders
79 Function and Evaluation of the Immune System
80 Systemic Lupus Erythematosus and Other Collagen Vascular Diseases
81 Allergic and Pseudoallergic Drug Reactions
Sect. 11 Bone and Joint Disorders
82 Osteoporosis and Osteomalacia
83 Rheumatoid Arthritis
84 Osteoarthritis
85 Gout and Hyperuricemia
Sect. 12 Disorders of the Eyes, Ears, Nose and Throat
86 Glaucoma
87 Allergic Rhinitis
Sect. 13 Dermatologic Disorders
88 Acne and Psoriasis
89 Drug-Induced Skin Reactions
Sect. 14 Hematologic Disorders
90 Hematopoiesis
91 Anemias
92 Coagulation Disorders
93 Sickle Cell Anemia
94 Drug-Induced Hematologic Disorders
Sect. 15 Infectious Diseases
95 Laboratory Tests to Direct Antimicrobial Pharmacotherapy
96 Antimicrobial Regimen Selection
97 Central Nervous System Infections
98 Lower Respiratory Tract Infections
99 Upper Respiratory Tract Infections
100 Skin and Soft Tissue Infections
101 Infective Endocarditis
102 Tuberculosis
103 Gastrointestinal Infections and Enterotoxigenic Poisonings
104 Intra-abdominal Infections
105 Parasitic Diseases
106 Urinary Tract Infections and Prostatitis
107 Sexually Transmitted Diseases
108 Bone and Joint Infections
109 Sepsis and Septic Shock
110 Invasive Fungal Infections
111 Infections in Immunocompromised Patients
112 Antimicrobial Prophylaxis in Surgery
113 Vaccines, Toxoids, and Other Immunobiologics
114 Human Immunodeficiency Virus Infection
Sect. 16 Oncologic Disorders
115 Cancer Treatment and Chemotherapy
116 Breast Cancer
117 Lung Cancer
118 Colorectal Cancer
119 Prostate Cancer
120 Malignant Lymphomas
121 Ovarian Cancer
122 Acute Leukemias
123 Chronic Leukemias
124 Melanoma
125 Bone Marrow Transplantation
Sect. 17 Nutrition and Nutritional Disorders
126 Assessment of Nutrition Status and Nutrition Requirements
127 Prevalence and Significance of Malnutrition
128 Parenteral Nutrition
129 Enteral Nutrition
130 Pediatric and Geriatric Nutrition Support
131 Nutritional Considerations in Major Organ Failure
132 Obesity
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