Pharmageddon [NOOK Book]

Overview

This searing indictment, David Healy’s most comprehensive and forceful argument against the pharmaceuticalization of medicine, tackles problems in health care that are leading to a growing number of deaths and disabilities. Healy, who was the first to draw attention to the now well-publicized suicide-inducing side effects of many anti-depressants, attributes our current state of affairs to three key factors: product rather than process patents on drugs, the classification of certain drugs as prescription-only, ...
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Pharmageddon

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Overview

This searing indictment, David Healy’s most comprehensive and forceful argument against the pharmaceuticalization of medicine, tackles problems in health care that are leading to a growing number of deaths and disabilities. Healy, who was the first to draw attention to the now well-publicized suicide-inducing side effects of many anti-depressants, attributes our current state of affairs to three key factors: product rather than process patents on drugs, the classification of certain drugs as prescription-only, and industry-controlled drug trials. These developments have tied the survival of pharmaceutical companies to the development of blockbuster drugs, so that they must overhype benefits and deny real hazards. Healy further explains why these trends have basically ended the possibility of universal health care in the United States and elsewhere around the world. He concludes with suggestions for reform of our currently corrupted evidence-based medical system.
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Editorial Reviews

Publishers Weekly
“We are quite literally taking drugs to save the lives of companies who have a greater interest in the vitality of the diseases they market drugs for than in our well-being,” argues British psychiatrist Healy (Let Them Eat Prozac) in this scathing critique of the billion global pharmaceutical industry. Healy chronicles the rise of blockbuster drugs like Prozac and Vioxx and how drug companies hyped them while downplaying their hazards. He takes particular aim at the outsourcing to private companies of clinical drug trials, once the domain of the National Institutes of Health and academics and now a billion industry. He is particularly incisive on how the drug industry distorts medical care by, say, encouraging the use of statins like Lipitor rather than advising patients to lose weight. But he seems contrarian in opposing chronic disease management because it provides drug companies the opportunity for long-term sales of drugs that manage, but do not cure, a condition. Still, Healy’s contrarian streak and sharpness make this a disturbing, well-documented indictment that echoes many others in recent years, and one worth heeding. Agent: Beverly Slopen, Beverly Slopen Literary Agency (Canada). (Mar.)
From the Publisher
"Healy's contrarian streak and sharpness make this a disturbing, well-documented indictment that echoes many others in recent years, and one worth heeding."—Publishers Weekly

"Powerful. . . . Healy exposes the secrets that enable drug companies to circumvent protections. . . . And he also offers a solution."—Human Givens

Human Givens

“Powerful. . . . Healy exposes the secrets that enable drug companies to circumvent protections. . . . And he also offers a solution.”
Metapsychology Online Reviews - E. James Lieberman
"We owe respect to David Healy for his knowledge, diligence and idealism. This and his other writings require expertise and courage..."
 
Library Journal
Healy (psychiatry, Cardiff Univ.; Let Them Eat Prozac: The Unhealthy Relationship Between the Pharmaceutical Industry and Depression) presents a well-documented and well-executed case against big pharma, forcing readers to think about both the pharmaceutical industry's role in their health care and the new development of drugs. Tracing how drug development and medical tests transitioned throughout the 20th century from addressing the diagnosis and cure of life-threatening diseases (e.g., X-rays, polio) to chronic disease management with potentially no end date (e.g., bone-density scans, bipolar disorder), the book tackles pharmaceutical companies' role in negligent clinical trials, ghostwriting in medical journals, new medical tests that encourage diagnosis, and the rise of blockbuster drugs. While other books address drug marketing (e.g., Marcia Angell's The Truth About the Drug Companies and John Abramson's Overdosed America), this title is much broader. Healy details the shift toward "lifestyle drugs," changes in patent law, hidden clinical trial results, off-label drugs use, and other topics. VERDICT Well written if sometimes dense, this book is for anyone who wishes to learn more about how the practice of medicine and development of drugs is changing.—Leigh Mihlrad, National Inst. of Health Lib., Bethesda, MD
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Product Details

  • ISBN-13: 9780520951815
  • Publisher: University of California Press
  • Publication date: 3/12/2012
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 1
  • Pages: 320
  • Sales rank: 405,486
  • File size: 355 KB

Meet the Author

David Healy is Professor of Psychiatry at Cardiff University in Britain and a former Secretary of the British Association for Psychopharmacology. He is the author of books including Let Them Eat Prozac: The Unhealthy Relationship Between the Pharmaceutical Industry and Depression, The Antidepressant Era, and Mania: A Short History of Bipolar Disorder.
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Read an Excerpt

Pharmageddon


By David Healy

UNIVERSITY OF CALIFORNIA PRESS

Copyright © 2012 David Healy
All rights reserved.
ISBN: 978-0-520-95181-5



CHAPTER 1

They Used to Call It Medicine


The careers of Alfred Worcester (1855–1951) and Richard Cabot (1868–1939) in Boston spanned the formative years of modern medicine. Worcester's medical training in the late nineteenth century included repeated visits to the homes of the sick and dying as a doctor's apprentice, whereas students of Cabot in the early twentieth century were trained in the new sciences basic to medicine, like bacteriology, and rarely got to meet the same patient more than once. Second-year medical students of 1912 knew more about diseases than the doctors of his generation ever did, Worcester conceded, but he argued that at the end of the day an exquisite knowledge of disease mechanisms was more likely to tell a doctor what his patients had died from rather than how to help them live or die. Older doctors, while not ignoring what they understood of disease processes, knew vastly more than their younger colleagues about human helplessness and were comfortable managing it. "It is when dealing with the mysteries of life that science fails the modern doctor," Worcester said.

Bemoaning a recent shift in Harvard that saw pharmacology now taught by someone who had never engaged in medical practice, Worcester noted that "in the modern medical schools science is enthroned. Carried away by the brilliance of etiological discoveries, the whole strength of the school is devoted to the study of disease. The art of medical practice is not taught; even its existence is hardly recognized." "Little wonder is it," he went on, that people "turn to the Christian Scientists, or other charlatans who, either in their absurd denial of the existence of disease or for mercenary reasons, at least leave some hope in the sick room."

Worcester's words have an uncomfortable ring of truth. But while we undoubtedly hope our doctor will be "old school," few if any of us are prepared to give up the benefits science has brought to medicine over the past century. Aware of the hazards of a narrowly "medical" approach, many medical schools, Harvard in particular, attempt to ensure that students realize an illness is but an episode in their patient's lives. But despite these efforts, clinical practice still seems to be degenerating.

Patients treated by Worcester might have seen him with an apprentice in tow or when they went to see Cabot at Massachusetts General they could well have encountered medical students sitting in on the visit. But now the pharmaceutical industry has been able to persuade doctors to allow trainee drug reps to sit in on clinics—recently illustrated in the movie Love and Other Drugs. For example, as part of her training as a sales representative, Jeanette got to sit in with Dr. N on a "medication management clinic." Dr. N is the fictional name for a real doctor—a high-volume prescriber of drugs—who is the subject of a research project looking at modern clinical practice. Jeanette was struck by the amount of paperwork he had to fill out on each patient—charts tracking both the doctor's and patient's perceptions of whether a drug was working and whether any side effects were apparent. He was so busy filling out the forms that he barely looked up during his 10- to 15-minute sessions with patients.

One day, a middle-aged man came in, and while Dr. N completed the paperwork for the previous patient, Jeanette engaged him. He seemed to be in a good mood considering he was in a wheelchair and recently had had both legs amputated because of vascular problems. Dr. N began to ask the usual questions, ticking boxes as he went.

Finally, the patient interrupted: "Look at me, Dr. Do you notice anything different about me?" He repeated this several times until Dr. N looked up and focused directly on the man, while pushing his glasses up with his thumb. He stared at the patient for several seconds and finally said, "No, I don't notice anything different, what's up?" The patient smiled and said excitedly, "I got my legs cut off since that last time you saw me!" Dr. N steered the conversation back to the patient's medication, and the session ended a few minutes later.

While this neglect may have been extreme even for the fictional Dr. N, many of us face something similar when we visit our doctors today; even the best seem to spend an increasing proportion of their time looking at computer screens rather than at us. While Cabot was more committed to the latest science than Worcester, there is little doubt that he would have been as appalled at this as Worcester might have been. There is moreover no reason to believe that an embrace of science should lead to such degradation of medical practice. The case of Dr. N, comically extreme as it is, puts in stark relief a type of medical practice encouraged by the dominant forces in healthcare today.

This book sets out to explain how we have come to a situation where a Dr. N can not just exist but may become something of the norm in the near future. As a first step we need to outline two histories, one a relatively traditional history of medicine's relation to drugs culminating with the emergence of a set of truly effective magic-bullet treatments in the middle years of the twentieth century and the other a history of marketing that starts in the late nineteenth century. These two histories initially have little in common but in recent years, as we shall show, medicine seems to have become the home of the most sophisticated marketing on earth. The transformation is undeniable but if we wish to change things it is not sufficient to simply assert there has been a transformation—we need to pinpoint the mechanisms driving the change.


FROM MEDICINE TO MARKETING

In a 1951 ad featuring American soldiers at war, the pharmaceutical company Eli Lilly outlined the contribution it and other companies were making to the United States:

A record of American Achievement. Thousands of Americans and of our allies too, are alive today because of the lifesaving gains made in World War II. The mortality rate of our own wounded dropped to the lowest level in the history of any army in the world. This was accomplished through better methods and techniques of medical care and especially through the use of new and improved pharmaceuticals. Tremendous quantities of penicillin, anesthetic agents, sulfonamides and processed blood were quickly supplied by such manufacturers as Eli Lilly and Company. The rewards of free enterprise had built an American industry large enough to do the job.


Ironically, most of the treatments mentioned in this ad were produced not through free enterprise but through government funding or by the prewar German pharmaceutical industry cartel IG Farben. During the 1950s and 1960s, Czechoslovakia, then part of the Soviet bloc, produced more new drugs per capita than any other country. Nevertheless, capitalism and free markets at some level "work." Everyone now recognizes this. And, given a choice between a system that produces the best hi-tech healthcare in the world and contributes to the development of breakthrough drugs but is run as a business or a system that isn't run as a business, puts a premium more on caring than on breakthrough drugs, and takes social factors into account in considering appropriate care, the average person will opt for breakthroughs every day of the week.

The problem with this free market view of the world, nowhere more so than in the pharmaceutical industry, is that the free markets that supposedly lead to better mousetraps were cannibalized in the twentieth century by what became a few large firms, one of them being Eli Lilly, that were then in a position to favor marketing over innovation as the ultimate key to their profits. Where the research and development budgets of large pharmaceutical companies like Lilly and Pfizer were once much greater than their marketing budgets, the reverse is now true. The pharmaceutical industry, for example, now spends $30 billion annually on marketing in the United States alone. In 2002, Pfizer devoted roughly $1.2 billion to marketing the statin Lipitor as a treatment for raised cholesterol levels, an amount equivalent to the US National Institutes of Health budget for research on Alzheimer's disease, arthritis, autism, epilepsy, influenza, multiple sclerosis, sickle cell disease, and spinal cord injury combined. Given that Lipitor was only one of six statins on the market at the time, anyone trying to get out a competing medical message—that statins have a very limited role in healthcare or that there are alternate ways to lower cholesterol through diet and other approaches—faces a daunting challenge. With money like this behind them, twenty-first-century corporate marketers are supremely confident they can sell anything. Bottled water, oxygen, and with the right packaging, even inferior mousetraps. And if they can do this, why not homeopathic or relatively worthless medicines?

Pharmaceutical companies have perhaps done more to undermine traditional markets than any other industrial companies. Not coincidentally, from Lilly's 1951 ad to a 2005 book by Hank McKinnell, then CEO of Pfizer, they are also the corporations most active in spreading the message that there is no alternative to a free enterprise system. But while in fact many industrial corporations came to the conclusion a century ago that the capitalism of cutthroat competition and free markets didn't work as well as it might—at least not for them—no other branch of industry has been able to pursue this agenda in quite the way pharmaceutical companies have.

To begin to see how pharmaceutical companies have engineered what they have, we need to return to the mid-nineteenth century when the first science-based companies began producing goods made possible by the new physical and chemical sciences. These sciences formed the basis of electrical manufacturing as well as the chemical and metal industries, leading to a string of new goods from automobiles to plastics, explosives, dyes, rubber products, artificial fibers, and, later, pharmaceuticals. In all these cases, competition between companies should in theory drive prices down in an open market, especially when increasing automation reduced the cost of production. Faced with the risk of falling profits, the new manufacturing companies commonly banded together in cartels to keep prices artificially high. A cartel presents the world with apparent competition between companies when in fact the companies have agreed among themselves to coordinate prices and market arrangements, allowing them to enjoy the advantages of de facto monopolies. But government resistance to cartels mounted in the United States and Europe at the end of the nineteenth century.

Companies needed to find another way to maintain or increase their profits. It was this that led to a turn to marketing. For manufacturers the problem was that as the genuine need for automobiles, plastics, dyes, nuts and bolts as well as mousetraps were increasingly met with capacity to spare, ever more production could only drive prices down. If prices could not be rigged by cartels, could demand be maintained or increased by tapping into what people might be persuaded they wanted or needed?

An appreciation of the opportunities that marketing opened up led to the emergence of marketing departments within companies and the first university courses on marketing in the 1920s. In a supreme irony, much of the raw material for these courses came from a brilliant set of ad hoc developments that underpinned the marketing of proprietary, over-the-counter medicines in the nineteenth century. The early exponents of the new science of marketing realized that the true experts on understanding what people might be persuaded they needed were quacks pushing worthless medical remedies. It was these who more than anyone else created advertising and shaped modern marketing.

One of the first lessons that proprietary medicines taught later marketers came in the 1830s, when a war broke out in the newspapers between Samuel Lee, Jr. of Connecticut who produced "Bilious Pills" and another Samuel Lee from Connecticut who also produced a Bilious Pills remedy. Far from leading to market collapse, this dispute spurred demand for Bilious Pills, and soon other proprietors across the country were joining in with their own preparations. In contrast to the producers of dyes and metal goods, these businessmen found competition among producers led to increase in sales for their commodities, without prices falling. In the drug domain this phenomenon has been demonstrated again and again from the marketing of Aspirin as a brand name product in the nineteenth century to that of Lipitor and Vioxx in this century.

In 1804, there were some ninety over-the-counter proprietary medicines listed in New York. By 1857, this had swollen to more than fifteen hundred countrywide. The growth in business paralleled the growth of the press and literacy. Where there were two hundred newspapers in 1800, there were four thousand by 1860. The proprietors of these remedies took advantage of this explosive growth and were among the first to market nationally. They also marketed heavily: the proprietary medicines industry spent more than any other industry on advertising in the second half of the nineteenth century. By the end of that century up to $1 million was being spent on telling the American people about the benefits of Scott's Emulsion, just one of an estimated fifty thousand compounds in a trade that had a retail value of several hundred million dollars.

The proprietary medicines industry was the first to market lifestyles rather than the compounds per se—this was marketing before the modern term had come into being. There was a simple reason for this: there was little if any value in these substances.The key ingredients were on the bottle rather than in it—the branding. It was no accident that one of the leading early lights in advertising, Claude Hopkins, would say that "the greatest advertising men of my day were schooled in the medicine field"—schooled, that is, in how to persuade the public that Carter's Little Liver Pills, Lydia Pinkham's Vegetable Compound, Clark Stanley's Snake Oil Liniment, or Coca Cola or, later, 7-UP would restore health or beauty, resolve halitosis, conquer fatigue, or ward off calamity. The money thrown into the marketing campaigns came from huge markups in the selling price of these compounds, typically inflated to five times their cost of production.

Marketing does exactly the same thing today when it gets us to believe that a particular running shoe or music system is not only necessary for its stated function but will deliver what we desire more generally in life—our unmet needs. These are the suggestions that underpin the marketing of bottled water and other such items that most people for most of the twentieth century never imagined could be marketed. And as the bottled waters of the twenty-first century along with the proprietary medicines of the nineteenth century (which contained little more than water) show so clearly, the differentiation between one product and another is seldom based on actual differences in the products but hinges rather on brand recognition, on how effective competing marketers are in encapsulating wish fulfillment, and in saturating potential purchasers with their message.

While there were differences in emphasis between medical men like Cabot and Worcester, during the period from 1850 to 1950 medicine was united in an implacable opposition to medical quackery and proprietary remedies—and by extension to marketing. In early nineteenth-century Europe and the United States, there was no licensing of physicians and no training in science as part of their education. Hospitals were almshouses for the poor rather than institutions with a mission to treat effectively. When people got sick, they increasingly turned to the remedies being advertised nationally and sold by salesmen, who peddled everything from cures for cancer to elixirs for love or eternal youth.

Faced with a proliferation in wild claims for cures for everything from consumption to nervous problems, the first European and American associations of physicians that emerged in the mid-nineteenth century committed themselves to ensuring medical doctors knew what they were prescribing and knew what there was to know about the conditions they were treating. In cases where no treatment seemed to work any better than judicious waiting, the new breed of doctors were educated in the virtue of waiting with their patients, trained to recognize as had Philippe Pinel that there was often a greater art in knowing when not to prescribe than in prescribing.

In Europe the greatest concern regarding these remedies was voiced over markups of 500 percent or more for compounds that contained little that might actually help patients. In the United States, where the proprietary industry flourished to the greatest extent, physicians expressed greater concern over the injuries some of these potions could cause. As Oliver Wendell Holmes put it at a meeting of the Massachusetts Medical Society in 1860,"I firmly believe that if the whole materia medica [the available drugs] could be sunk to the bottom of the sea it would be all the better for mankind—and all the worse for the fishes."


(Continues...)

Excerpted from Pharmageddon by David Healy. Copyright © 2012 David Healy. Excerpted by permission of UNIVERSITY OF CALIFORNIA PRESS.
All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.
Excerpts are provided by Dial-A-Book Inc. solely for the personal use of visitors to this web site.

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Table of Contents

Acknowledgments

Introduction
1. They Used to Call It Medicine
2. Medicine and the Marketers
3. Follow the Evidence
4. Doctoring the Data
5. Trussed in Guidelines
6. The Mismeasurement of Medicine
7. The Eclipse of Care
8. Pharmageddon

Notes
Index
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