Phosphatase Modulators

Overview

Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one “how to” manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” decisions in high throughput screening (HTS) and ...

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Overview

Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one “how to” manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results.

Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts.

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Product Details

  • ISBN-13: 9781627035613
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 7/31/2013
  • Series: Methods in Molecular Biology Series , #1053
  • Edition description: 2013
  • Edition number: 1
  • Pages: 315
  • Product dimensions: 7.16 (w) x 10.30 (h) x 0.94 (d)

Table of Contents

1. Chemical Probe Development Versus Drug Development

Michael R. Jackson

2. Phosphatase High-Throughput Screening Assay Design and Selection

Eduard A. Sergienko

3. Multisystemic Functions of Alkaline Phosphatases

René Buchet, José Luis Millán, and David Magne

4. Robotic Implementation of Assays: Tissue-Nonspecific Alkaline Phosphatase (TNAP) Case Study

Thomas D.Y. Chung

5. Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP): From Hits to Leads

Peter Teriete, Anthony B. Pinkerton, and Nicholas D.P. Cosford

6. A Method for Direct Assessment of Tissue-Nonspecific Alkaline Phosphatase (TNAP) Inhibitors in Blood Samples

Eduard Sergienko, Qing Sun, and Chen-Ting Ma

7. Isolation and Characteristics of Matrix Vesicles

René Buchet, Slawomir Pikula, David Magne, and Saïda Mebarek

8. The Use of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 Inhibitors to Affect Mineralization by Cultured Cells

Tina Kiffer-Moreira and Sonoko Narisawa

9. Modulators of Intestinal Alkaline Phosphatase

Ekaterina V. Bobkova, Tina Kiffer-Moreira, and Eduard A. Sergienko

10. New Activity Assays for ENPP1 with Physiological Substrates ATP and ADP

Chen-Ting Ma and Eduard Sergienko

11. Structure of Acid Phosphatases

César L. Araujo and Pirkko T. Vihko

12. Purification of Prostatic Acid Phosphatase (PAP) for Structural and Functional Studies

Annakaisa M. Herrala, Ileana B. Quintero, and Pirkko T. Vihko

13. Protein Tyrosine Phosphatases: Structure, Function, and Implication in Human Disease

Lutz Tautz, David A. Critton, and Stefan Grotegut

14. High-Throughput Screening for Protein Tyrosine Phosphatase Activity Modulators

Lutz Tautz and Eduard A. Sergienko

15. Evaluating Effects of Tyrosine Phosphatase Inhibitors on T Cell Receptor Signaling

Souad Rahmouni, Laurence Delacroix, Wallace H. Liu, and Lutz Tautz

16. Interactor-Guided Dephosphorylation by Protein Phosphatase-1

Shannah Boens, Kathelijne Szekér, Aleyde Van Eynde, and Mathieu Bollen

17. Structure, Regulation, and Pharmacological Modulation of PP2A Phosphatases

Caroline Lambrecht, Dorien Haesen, Ward Sents, Elitsa Ivanova, and Veerle Janssens

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