Phosphatases in Cell Metabolism and Signal Transduction: Structure, Function and Mechanism of Action

Overview

This book is about the chemistry of phosphate monoester hydrolysis catalyzed by enzymes called phosphatases, focusing on their chemistry at a molecular level, i.e. their structure, function, and mechanism of action. At present, six classes of phosphatase are well characterized: (i) alkaline phosphatases, (ii) purple acid phosphatases, (iii) high molecular weight acid phosphatases, (iv) low molecular weight acid phosphatases, (v) phosphotyrosine phosphatases, and (vi) serine/threonine phosphatases. This book ...

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1995 Hardcover 1570592969. Brand New;

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Overview

This book is about the chemistry of phosphate monoester hydrolysis catalyzed by enzymes called phosphatases, focusing on their chemistry at a molecular level, i.e. their structure, function, and mechanism of action. At present, six classes of phosphatase are well characterized: (i) alkaline phosphatases, (ii) purple acid phosphatases, (iii) high molecular weight acid phosphatases, (iv) low molecular weight acid phosphatases, (v) phosphotyrosine phosphatases, and (vi) serine/threonine phosphatases. This book presents a comprehensive overview of phosphatases, comparing and contrasting Nature's different solutions to the problem of phosphate monoester hydrolysis. This is the first thorough survey and comparison of these different types of phosphatases. It focuses on chemistry, not biology.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Juergen Mollenhauer, PhD, DSc (Rush Medical College of Rush University)
Description: This book focuses on the enzyme chemistry of acid and alkaline phosphatases in the intracellular and extracellular environments and relates their chemical properties to the metabolic functions within the signal transduction pathways, lysosomal activities, and the generation of extracellular conditions, as in bone.
Purpose: The book is the first comprehensive overview on that matter. Besides a description of the chemical properties, an attempt is made to explain the properties of the various enzymes in the context of the metabolic needs of cells in different environments.
Audience: The book is written for persons with a significant background knowledge in enzyme chemistry and physical chemistry (spectroscopy), because most of the enzymes' particular chemistry is presented via raw data. Little attempt is made to explain the presented sets of original data to inexperienced readers.
Features: Because of how the data are presented, the book sometimes has the appearance of an original contribution in a typical scientific journal rather than of a review of a research field. However, this gives the technically experienced reader a chance for a personal interpretation of the data. Unfortunately, sometimes the technical quality of the printed graphs suffers: curves appear in part dotted although originally obtained as straight lines, because of insufficient reproduction of computer-generated laboratory data curves; some explanatory figures have a blurred appearance. The index is poor and does not help in searching for particular details.
Assessment: The title is somehow misleading, because the biological functions are not a major aspect. The book is very up-to-date, with literature included until 1995. This, together with the scientific content, is the real strength of the book. It deserves better editing, proofreading, and printing. In a time when most literature on phosphatases is written from the standpoint of molecular and cell biologists, this book offers a favorable contrast.
Juergen Mollenhauer
This book focuses on the enzyme chemistry of acid and alkaline phosphatases in the intracellular and extracellular environments and relates their chemical properties to the metabolic functions within the signal transduction pathways, lysosomal activities, and the generation of extracellular conditions, as in bone. The book is the first comprehensive overview on that matter. Besides a description of the chemical properties, an attempt is made to explain the properties of the various enzymes in the context of the metabolic needs of cells in different environments. The book is written for persons with a significant background knowledge in enzyme chemistry and physical chemistry (spectroscopy), because most of the enzymes' particular chemistry is presented via raw data. Little attempt is made to explain the presented sets of original data to inexperienced readers. Because of how the data are presented, the book sometimes has the appearance of an original contribution in a typical scientific journal rather than of a review of a research field. However, this gives the technically experienced reader a chance for a personal interpretation of the data. Unfortunately, sometimes the technical quality of the printed graphs suffers: curves appear in part dotted although originally obtained as straight lines, because of insufficient reproduction of computer-generated laboratory data curves; some explanatory figures have a blurred appearance. The index is poor and does not help in searching for particular details. The title is somehow misleading, because the biological functions are not a major aspect. The book is very up-to-date, with literature included until 1995. This, together with thescientific content, is the real strength of the book. It deserves better editing, proofreading, and printing. In a time when most literature on phosphatases is written from the standpoint of molecular and cell biologists, this book offers a favorable contrast.
Booknews
A summary of the mechanisms for phosphate monoester hydrolysis, first examining the manners in which this hydrolysis is catalyzed by simple model complexes. Subsequently, the six well-characterized classes of enzymes which catalyze phosphate monoester hydrolysis-- phosphatases--are examined in detail: serine/threonine phosphatases, purple acid phosphatases, low molecular weight acid phosphatases, and high molecular weight phosphatases. The discussions focus on the chemistry of these enzymes on a molecular level, i.e., their structure, function, and mechanism of action. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

Table of Contents

Preface
1 Introduction 1
2 Mechanisms and Models 3
3 Protein Phosphatases Part A: Phosphoprotein Serine/Threonine Phosphatases 7
4 Protein Phosphatases Part B: Phosphotyrosine Phosphatases 61
5 Metal-Containing Phosphatases Part A: Alkaline Phosphatases 99
6 Metal-Containing Phosphatases Part B: Purple Acid Phosphatases 111
7 Low Molecular Weight Acid Phosphatases 159
8 High Molecular Weight Acid Phosphatases 175
9 Other Phosphatases 193
10 Conclusion 199
Index 201
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