Phosphoinositide 3-kinase in Health and Disease: Volume 1 / Edition 1

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Overview

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phoshoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.

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Product Details

Table of Contents

Introduction Tina L. Yuan Lewis C. Cantley 1

PDK1: The Major Transducer of PI 3-Kinase Actions José Ramón Bayascas 9

Protein Kinase B (PKB/AKt), a Key Mediator of the PI3K Signaling Pathway Elisabeth Fayard Gongda Xue Arnaud Parcellier Lana Bozulic Brian A. Hemmings 31

PI3Ks in Lymphocyte Signaling and Development Klaus Okkenhaug David A. Fruman 57

The Regulation of Class IA PI 3-Kinases by Inter-Subunit Interactions Jonathan M. Backer 87

Phosphoinositide Signalling Pathways in Metabolic Regulation Lazaros C. Foukas Dominic J. Withers 115

Role of RAS in the Regulation of PI 3-Kinase Esther Castellano Julian Downward 143

More Than Just Kinases: The Scaffolding Function of PI3K Carlotta Costa Emilio Hirsch 171

PI3K Signaling in Neutrophils Phillip T. Hawkins Len R. Stephens Sabine Suire Michael Wilson 183

PI 3-Kinase p110β Regulation of Platelet Integrin αIIbβ3 Shaun P. Jackson Simone M. Schoenwaelder 203

Regulatory Subunits of Class IA PI3K David A. Fruman 225

The Neurodevelopmental Implications of PI3K Signaling Kathryn Waite Britta J. Eickholt 245

PI3 Kinase Regulation of Skeletal Muscle Hypertrophy and Atrophy David J. Glass 267

Taking PI3Kδ and PI3Kγ One Step Ahead: Dual Active PI3Kδ/γ Inhibitors for the Treatment of Immune-Mediated Inflammatory Diseases Christian Rommel 279

Index 301

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