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Phosphoinositide 3-kinase in Health and Disease: Volume 2 / Edition 1

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Overview

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trails of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.

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Product Details

Table of Contents

PI3K: From the Bench to the Clinic and Back Bart Vanhaesebroeck Peter K. Vogt Christian Rommel 1

Oncogenic Mutations of PIK3CA in Human Cancers Yardena Samuels Todd Waldman 21

Structural Effects of Oncogenic PI3Kα Mutations Sandra B. Gabelli Chuan-Hsiang Huang Diana Mandelker Oleg Schmidt-Kittler Bert Vogelstein L. Mario Amzel 43

Comparing the Roles of the pll0α and pll0β Isoforms of PI3K in Signaling and Cancer Nina Ilic Thomas M. Roberts 55

Phosphatidylinositol 3-Kinase: The Oncoprotein Peter K. Vogt Jonathan R. Hart Marco Gymnopoulos Hao Jiang Sohye Kang Andreas G. Bader Li Zhao Adam Denley 79

AKT Signaling in Physiology and Disease Krishna M. Vasudevan Levi A. Garraway 105

Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse Caterina Nardella Arkaitz Carracedo Leonardo Salmena Pier Paolo Pandolfi 135

PI3K as a Target for Therapy in Haematological Malignancies Asim Khwaja 169

Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors Carlos L. Arteaga 189

From the Bench to the Bed Side: PI3K Pathway Inhibitors in Clinical Development Saveur-Michel Maira Peter Finan Carlos Garcia-Echeverria 209

New Inhibitors of the PI3K-Akt-mTOR Pathway: Insights into mTOR Signaling from a New Generation of Tor Kinase Domain Inhibitors (TORKinibs) Morris E. Feldman Kevan M. Shokat 241

Small Molecule Inhibitors of the PI3-Kinase Family Zachary A. Knight 263

Targeting the RTK-PI3K-mTOR Axis in Malignant Glioma: Overcoming Resistance Qi-Wen Fan William A. Weiss 279

Index 297

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