Phospholipid Metabolism in Apoptosis / Edition 1

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The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. It is now well recognised that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The molecular mechanisms of apoptosis are presently unknown and the subject of focused research effort. It is clear that cell membrane structure and properties play an early part in the induction process. There is increasing evidence that the arrangement of polar lipids in the membrane lipid matrix is an important factor coupled with the homeostatic mechanisms responsible for preserving membrane lipid composition and asymmetry. Changes in membrane permeability are also likely to be involved, possibly as a direct consequence of disturbances in the lipid bilayer matrix.
The purpose of this volume is to examine the involvement of membrane lipids in early events of apoptosis. In particular, the role of phospholipids in mihondrial permeability, membrane lipid asymmetry, and sphingolipid and phospholipid signalling processes in early apoptotic events are reviewed by current researchers in these fields.

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Editorial Reviews

From The Critics
Reports on recent progress made in understanding the role membrane lipids play in the molecular mechanisms of apoptosis. In particular, the role of phospholipids in mitochondrial permeability, membrane lipid asymmetry, and sphingolipid and phospholipid signaling processes in early apoptotic events are reviewed. The action of ceramides in regulating glycerophospholipid biosynthesis and the generation of signaling molecules is addressed in several chapters. Other topics of the 16 papers include the release of cytochrome c from mitochondria, the induction of apoptosis by redox-cycling quinones, and the role of nitric oxide and membrane phospholipid polyunsaturation in oxidative cell death. Annotation c. Book News, Inc., Portland, OR
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Product Details

  • ISBN-13: 9780306467820
  • Publisher: Springer US
  • Publication date: 5/31/2002
  • Series: Subcellular Biochemistry Series, #36
  • Edition description: 2002
  • Edition number: 1
  • Pages: 340
  • Product dimensions: 6.34 (w) x 9.22 (h) x 1.13 (d)

Table of Contents

Lipid Metabolism and Release of Cytochrome c from Mitochondria 1
Interaction between Cytochrome c and Oxidized Mitochondrial Lipids 19
Plasma Membrane Phospholipid Asymmetry 39
Apoptosis by Phosphatidylserine in Mammalian Cells 61
Phosphatidylserine Peroxidation during Apoptosis 79
Role of Nitric Oxide and Membrane Phospholipid Polyunsaturation in Oxidative Cell Death 97
Oxidized LDL-induced Apoptosis 123
Induction of Apoptosis by Redox-cycling Quinones 151
Apoptosis Induced by Ionizing Radiation 171
Ceramidases in the Regulation of Ceramide Levels and Function 187
Effect of Ceramides on Phospholipid Biosynthesis and Its Implication for Apoptosis 207
Acid Sphingomyelinase-derived Ceramide Signaling in Apoptosis 229
Cellular Signaling by Sphingosine and Sphingosine 1-phosphate 245
Ceramide in Regulation of Apoptosis 269
Lipid Signaling in CD95-mediated Apoptosis 285
Phosphatidylinositol 3-kinase, Phosphoinositides and Apoptosis 309
Index 335
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