Physical Biology: From Atoms to Medicine

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Overview

This is an avant-garde book edited by Nobel Laureate Ahmed Zewail with contributions from eminent scientists including four Nobel prize winners. The perspectives of these world leaders in physics, chemistry, and biology define potential new frontiers at the interface of disciplines and including physical, systems, and synthetic biology.

The book brings about the confluence of concepts and tools, and that of different disciplines, to address significant problems of our time: visualization; theory and computation for complexity; macromolecular function, protein folding and misfolding; and systems integration from cells to consciousness. The scope of tools is wide-ranging, spanning imaging, crystallography, microfluidics, single-molecule spectroscopy, and synthetic probe targeting. Concepts such as dynamic self-assembly, molecular recognition, non-canonical amino acids, and others are covered in various chapters as they are cornerstones in building the trilogy description of behavior-structure, dynamics, and function.

The volume is uniquely structured to provide overviews with historical perspectives on the evolution of ideas and on the future of physical biology and biological complexity, from atoms to medicine.

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Product Details

  • ISBN-13: 9781848161993
  • Publisher: Imperial College Press
  • Publication date: 5/28/2008
  • Pages: 567
  • Product dimensions: 6.30 (w) x 9.10 (h) x 1.50 (d)

Table of Contents

Prologue Ahmed H. Zewail Zewail, Ahmed H.

Ch. 1 The Preoccupations of Twenty-First-Century Biology David Baltimore Baltimore, David 1

Ch. 2 The World as Physics, Mathematics and Nothing Else Alexander Varshavsky Varshavsky, Alexander 7

Ch. 3 Physical Biology: 4D Visualization of Complexity Ahmed H. Zewail Zewail, Ahmed H. 23

Ch. 4 Revolutionary Developments from Atomic to Extended Structural Imaging John Meurig Thomas Thomas, John Meurig 51

Ch. 5 Physical Biology at the Crossroads Carlos J. Bustamante Bustamante, Carlos J. 115

Ch. 6 The Challenge of Quasi-Regular Structures in Biology Roger D. Kornberg Kornberg, Roger D. 137

Ch. 7 The Future of Biological X-Ray Analysis Douglas C. Rees Rees, Douglas C. 145

Ch. 8 Reinterpreting the Genetic Code: Implications for Macromolecular Design, Evolution and Analysis David A. Tirrell Tirrell, David A. 165

Ch. 9 Designing Ligands to Bind Tightly to Proteins George M. Whitesides Whitesides, George M. Phillip W. Snyder Snyder, Phillip W. Demetri T. Moustakas Moustakas, Demetri T. Katherine A. Mirica Mirica, Katherine A. 189

Ch. 10 Biology by the Numbers Rob Phillips Phillips, Rob 217

Ch. 11 Eppur si muove Michele Parrinello Parrinello, Michele 247

Ch. 12 Protein Folding and Beyond: Energy Landscapes and the Organization of Living Matter in Time and Space Peter G. Wolynes Wolynes, Peter G. 267

Ch. 13 Protein Folding and Misfolding: From Atoms to Organisms Christopher M. Dobson Dobson, Christopher M. 289

Ch. 14 A Systems Approach to Medicine Will Transform Healthcare Leroy Hood Hood, Leroy 337

Ch. 15 The Neurobiology of Consciousness Christof Koch Koch, Christof Florian Mormann Mormann, Florian 367

Ch. 16Computer-Aided Drug Discovery: Physics-based Simulations from the Molecular to the Cellular Level J. Andrew McCammon McCammon, J. Andrew 401

Ch. 17 Precision Measurements in Biology Stephen R. Quake Quake, Stephen R. 411

Ch. 18 Potassium Channels and the Atomic Basis of Selective Ion Conduction Roderick MacKinnon MacKinnon, Roderick 431

The 2007 Welch Award Papers 463

Ch. 19 Symmetry Breaking, Delocalization and Dynamics in Electron Transfer Systems Noel S. Hush Hush, Noel S. 465

Ch. 20 The Initial Value Representation of Semiclassical Theory: A Practical Way for Adding Quantum Effects to Classical Molecular Dynamics Simulations of Complex Molecular Systems William H. Miller Miller, William H. 505

Biographies 527

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