Physical Methods to Characterize Pharmaceutical Proteins / Edition 1

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This collection of state-of-the-art research describes the most frequently used techniques for structural analysis of proteins. Chapters focus on the impressive progress that has been made in the development of these techniques and identify future trends and research needs. Papers feature several spectroscopic techniques-including fluorescence spectroscopy, circular dichroism, and infrared spectroscopy.

Fourier transform infrared spectroscopy investigations of protein structure/capillary electrophoresis of proteins/etc.

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Editorial Reviews

Reports on the current status and research trends of methods to characterize the physical traits of proteins used in vaccines and therapeutic and diagnostic pharmaceuticals. Considers several spectroscopic techniques, chromatography, capillary electrophoresis, and genetic engineering to analyze such features as three-dimensional structure, hydrodynamic and thermodynamic properties, and kinetics, especially of liquid and freeze-dried products during their shelf life. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780306450266
  • Publisher: Springer US
  • Publication date: 9/30/1995
  • Series: Pharmaceutical Biotechnology (closed) Series, #7
  • Edition description: 1995
  • Edition number: 1
  • Pages: 362
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.88 (d)

Table of Contents

Ch. 1 Application of Fluorescence Spectroscopy for Determining the Structure and Function of Proteins
Ch. 2 Structural Information on Proteins from Circular Dichroism Spectroscopy: Possibilities and Limitations
Ch. 3 Fourier Transform Infrared Spectroscopy Investigations of Protein Structure
Ch. 4 Mass Spectrometry in Protein Structural Analysis
Ch. 5 Two-, Three-, and Four-Dimensional Nuclear Magnetic Resonance Spectroscopy of Protein Pharmaceuticals
Ch. 6 Thermodynamic Strategies for Rational Protein and Drug Design
Ch. 7 Chromatographic Techniques for the Characterization of Proteins
Ch. 8 Capillary Electrophoresis of Proteins
Ch. 9 Applying Genetic Engineering to the Structural Analysis of Proteins
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