Physiology and Pathophysiology of the Heart / Edition 2by Nicholas Sperelakis
Pub. Date: 01/31/1989
Publisher: Springer US
could go on for several pages. Thus the book edited This book emphasizes the fundamental, functional aspects of cardiology. Within the last thirty years, by Sperelakis IS a potent reminder of the almost for the rift between clinical and investigative cardiology gotten fact that cardiology has twO sites, inextrica has widened, because of the overwhelming
could go on for several pages. Thus the book edited This book emphasizes the fundamental, functional aspects of cardiology. Within the last thirty years, by Sperelakis IS a potent reminder of the almost for the rift between clinical and investigative cardiology gotten fact that cardiology has twO sites, inextrica has widened, because of the overwhelming devel bly related. opment of new clinical procedures, both diagnostic The book deals with subjects in which Dr. Sper and therapeutic. Almost forgotten is the fact that elakis has pioneered: ultrastructure of heart muscle, we owe most of the clinical advances to theoretical electrophysiology, cardiac contractility, and ion ex and experimental observations. I need not remind change. An extension of these subjects is the chapter the reader of the work of Carrel, who performed the dealing with fundamental topics of the coronary cir first experimental coronary bypass in 1902, or the culation. work of the brothers Curie in 1880, both physicists, This book is indeed a timely reminder of the im who discovered piezoelectricity, the keystone in ech portance of the fundamental aspects of cardiology. ogradiography; of the works of Langley, who intro Emphasis on clinical aspects of cardiology alone will duced the receptors concept; of Ahlquist in 1946, result in a sterile and unproductive future for a field who first differentiated between alpha and beta re that has made such stunning advances during the ceptors; of Fleckenstein, a physiologist who pi last thirty years to the benefit of millions of people.
Table of Contents
I. Cardiac Muscle.- 1. Ultrastructure of Mammalian Cardiac Muscle.- 2. Basic Pathologic Processes of the Heart: Relationship to Cardiomyopathies.- 3. Electrical Properties of Cells at Rest and Maintenance of the Ion Distributions.- 4. The Ionic Basis of Electrical Activity in the Heart.- 5. Electrogenesis of Pacemaker Potential as Revealed by AV Nodal Experiments.- 6. Cable Properties and Conduction of the Action Potential: Excitability, Sources, and Sinks.- 7. The Electrocardiogram and Its Relationship to Excitation of the Heart.- 8. The Slow Action Potential and Properties of the Myocardial Slow Channels.- 9. Excitation—Contraction Coupling: Relationship of the Slow Inward Current to Contraction.- 10. The Role of Na—Ca Exchange in Heart.- 11. Methods for Detecting Calcium Release from the Sarcoplasmic Reticulum of Skinned Cardiac Cells and the Relationships between Calculated Transsarcolemmal Calcium Movements and Calcium Release.- 12. Uptake of Calcium by the Sarcoplasmic Reticulum and Its Regulation and Functional Consequences.- 13. Contractile and Mechanical Properties of the Myocardium.- 14. Substrate and Energy Metabolism of the Heart.- 15. Neural Control of the Heart.- 16. The Development of Postsynaptic Cardiac Autonomic Receptors and Their Regulation of Cardiac Function during Embryonic, Fetal, and Neonatal Life.- 17. Mechanisms of Adrenergic and Cholinergic Regulation of Myocardial Contractility.- 18. The Pharmacology of Cardiac Glycosides.- 19. Effects of and the Mechanism of Action of Calcium Antagonists and Other Antianginal Agents.- 20. Cellular Electrophysiology and Ischemia.- 21. Mechanism of Action of Antiarrhythmic Drugs.- 22. Calcium and the Injured Cardiac Myocyte.- 23. Cell Coupling and Healing-over in Cardiac Muscle.- 24. Effects of Cardiotoxins on Membrane Ionic Channels.- 25. Cardiac Hypertrophy and Altered Cellular Electrical Activity of the Myocardium: Possible Electrophysiologic Basis for Myocardial Contractility Changes.- 26. Developmental Changes in Membrane Electrical Properties of the Heart.- 27. Aging of the Adult Heart.- 28. Hormonal Effects on Cardiac Performance.- 29. Cardioplegia: Principles and Problems.- 30. The Effects of the Volatile Anesthetic Agents on the Heart.- II. Coronary Circulation.- 31. Effects of Toxic Substances on the Heart.- 32. Vascular Smooth Muscle Cells and Other Periendothelial Cells of Mammalian Heart.- 33. The Pathogenesis of Coronary Atherosclerosis.- 34. Electrophysiology of Vascular Smooth Muscle.- 35. Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle.- 36. Vascular Muscle Membrane Properties in Hypertension.- 37. Mechanical Properties, Contractile Proteins, and Regulation of Contraction of Vascular Smooth Muscle.- 38. Metabolism and Energetics of Vascular Smooth Muscle.- 39. Control of the Coronary Circulation.- 40. Coronary Artery Spasm.
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