Physiology and Pathophysiology of the Heart / Edition 2

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Overview

Physiology and Pathophysiology of the Heart, Third Edition like its predecessors, provides the foundation of the basic science aspects of cardiac function and dysfunction, and attempts to bridge the gap between basic cardiovascular science and clinical science. As before, the third edition is divided into two major sections, cardiac muscle and coronary circulation. The book is multidisciplinary in approach, and integrates all relevant aspects of the factors influencing the function of the heart under normal and several abnormal conditions. It also provides a foundation for understanding the mechanism of action of various types of cardioactive drugs, including antiarrhythmic drugs and positive inotropic agents. The third edition includes 14 new chapters covering topics that were not covered in the second edition. These include two new chapters on the molecular structure of ion channels and several new chapters on the ionic channels of myocardial cells, vascular smooth muscle cells, and endothelial cells. New chapters are also included on release of Ca[superscript 2+] from the SR, and on the action of phospholipids released during ischemia on ion channels and production of disrhythmias. These new additions make Physiology and Pathophysiology of the Heart, Third Edition substantially more complete and up-to-date with respect to recent developments in cardiovascular science.

Ultrastructure of mammalian cardiac muscle/cardiac sodium- calcium exchange system/cell coupling & healing over/etc.

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Editorial Reviews

Booknews
A reference that provides the foundation of the basic science aspects of cardiac function and dysfunction, bridging the gap between basic cardiovascular science and clinical science. Divided into two major sections on cardiac muscle and coronary circulation, the volume integrates all relevant aspects of the factors influencing the function of the heart under normal and several abnormal conditions. It also provides a foundation for understanding of the mechanism of action of various types of cardioactive drugs, including antiarrhythmic drugs and positive inotropic agents. This revised and updated edition adds 14 new chapters, including two on the molecular structure of ion channels, and several on the ionic channels of myocardial cells, vascular smooth muscle cells, and endothelial cells. Annotation c. Book News, Inc., Portland, OR (booknews.com)
From the Publisher
'It is a book worth reading and presents an outstanding overview about the present day knowledge in this field which has been thankfully put together in this edited version by Sperelakis. This book deserves to be recommended for those who are interested in the biochemistry, biochemical physiology, pharmacology and pathophysiology of the heart.'
Heart and Circulation, 17:9 (1985)
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Product Details

Table of Contents

Contributing Authors
Foreword to the Third Edition
Foreword to the Second Edition
Foreword to the First Edition
Preface to the Third Edition
Preface to the Second Edition
Preface to the First Edition
1 Ultrastructure of Mammalian Cardiac Muscle 1
2 Basic Pathological Processes of the Heart: Relationship to Cardiomyopathies 37
3 Basis of the Cardiac Resting Potential 55
4 Ionic Basis of Electrical Activity in the Heart 77
5 Molecular Structure of the Cardiac Calcium Channel 91
6 Molecular Structure of Potassium and Sodium Channels and their Structure-Function Correlation 101
7 Calcium Regulation of Ion Channels in Cardiomyocytes 115
8 ATP-Sensitive K[superscript +] Channels in the Cardiovascular System 125
9 Electrogenesis of the Pacemaker Potential as Revealed by Atrioventricular Nodal Experiments 137
10 Cardiac Excitability, Gap Junctions, Cable Properties, and Impulse Propagation 153
11 The Electrocardiogram and its Relationship to Excitation of the Heart 201
12 The Slow Action Potential and Properties of the Myocardial Slow Ca Channels 241
13 Excitation-Contraction Coupling: Relationship of Calcium Currents to Contraction 269
14 Cardiac Excitation-Contraction Coupling: From Global to Microscopic Models 289
15 Cardiac Sodium-Calcium Exchange System 309
16 Basic Calculations of Transsarcolemmal Calcium Movements in Cardiac Excitation-Contraction Coupling 319
17 Uptake of Calcium by Sarcoplasmic Reticulum and its Regulation and Functional Consequences 333
18 Control Mechanisms Regulating Contractile Activity of Cardiac Myofilaments 355
19 Contractile and Mechanical Properties of the Myocardium 367
20 Substrate and Energy Metabolism of the Heart 385
21 Autonomic Neural Control of Cardiac Function 413
22 Embryonic Development and Regulation of Cardiac Autonomic Responsiveness 431
23 Alpha-Adrenergic Modulation of Cardiac Rhythm in the Developing Heart 457
24 Mechanisms of Adrenergic and Cholinergic Regulation of Myocardial Contractility 467
25 Pharmacology of Cardiac Glycosides 495
26 Calcium Channels and the Mechanism of Action of Calcium Antagonists 511
27 Lipid-Derived Amphiphiles and their Contribution to Arrhythmogenesis During Ischemia 527
28 Cellular Electrophysiology and Ischemia 547
29 Basic Principles of Pharmacokinetics: Antiarrhythmic Drugs 565
30 Mechanism of Action of Antiarrhythmic Drugs 589
31 Role of Calcium in Cardiac Cell Damage and Dysfunction 605
32 Cell Coupling and Healing-Over in Cardiac Muscle 625
33 Interactions of Natural Toxins with Ion Channels in Heart 635
34 Cellular Electrical Activity of the Myocardium: Possible Electrophysiological Basis for Myocardial Contractility Changes 653
35 Developmental Changes in Membrane Electrical Properties of the Heart 669
36 Aging of the Adult Heart 701
37 Hormonal Effects on Cardiac Performance 719
38 Cardioplegia Principles and Problems 731
39 Effects of the Volatile Anesthetic Agents on the Heart 745
40 Effects of Toxic Substances on the Heart 769
41 Adenosine and Adenine Nucleotide Action on Cardiac Cellular Excitation 789
42 Vascular Smooth Muscle Cells and Other Periendothelial Cells of Mammalian Heart 803
43 Pathogenesis of Coronary Atherosclerosis 827
44 Endothelial Control of Vascular Smooth Muscle: The Importance of Nitric Oxide 849
45 Electrophysiology of Vascular Smooth Muscle 859
46 Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle Cells 895
47 Regulation of Calcium and Chloride Channels in Vascular Smooth Muscle Cells by Norepinephrine 909
48 Calcium-Activated K[superscript +] Channels from Coronary Smooth Muscle: Mechanisms of Modulation and Role in Cardiac Function 919
49 ATP-Sensitive Potassium Channels: Properties, Distribution, and Role in Cardiovascular Regulation 935
50 Mechanisms of Action of K[superscript +] Channel Openers and Closers in Smooth Muscle Cells 945
51 Ion Channels of Endothelial Cells 961
52 Cyclic Nucleotides and Protein Phosphorylation in Vascular Smooth Muscle Relaxation 975
53 Vascular Muscle Membrane Properties in Hypertension 999
54 Contractile Proteins of Smooth Muscle 1011
55 Mechanical Properties and Regulation of Vascular Smooth Muscle Contraction 1047
56 Metabolism and Energetics of Vascular Smooth Muscle 1069
57 Control of the Coronary Circulation 1087
58 Extravascular Coronary Resistance 1109
59 Myocardial Infarction 1125
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