Physiology and Pharmacology of Biological Rhythms / Edition 1

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This volume provides a concise and accessible account of recent developments in chronobiology and of the implications and applications of chronobiological principles in pharmacology and medicine. The molecular biology and genetics of circadian clocks are considered along with the neuroanatomy and neurochemistry of the vertebrate clock. Recent advances in our understanding of entrainment mechanisms are also described. Special emphasis is placed on the importance of chronobiology in pharmacology and therapeutics, and the existence of biological rhythms in physiological and pathological processes.

Regulation of cell division cycles by circadian oscillators, rhythms in second messenger mechanisms, etc.

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Editorial Reviews

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"...a milestone in the development of chronophysiology and chronopharmacology...This outstanding publication is recommended to pharmacologists and chronobiologists, whether basic, applied, or clinical." Chronobiology International
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Product Details

  • ISBN-13: 9783642082658
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 12/9/2010
  • Series: Handbook of Experimental Pharmacology Series, #125
  • Edition description: Softcover reprint of hardcover 1st ed. 1997
  • Edition number: 1
  • Pages: 668
  • Product dimensions: 1.39 (w) x 9.21 (h) x 6.14 (d)

Table of Contents

1 The Vertebrate Clock: Localisation, Connection and Entrainment.- 2 Regulation of Cell Division Cycles by Circadian Oscillators: Signal Transduction Between Clocks.- 3 Genetics and Molecular Biology of Circadian Clocks.- 4 Chemical Neuroanatomy of the Mammalian Circadian System.- 5 Chronobiology of Development and Aging.- 6 Rhythms in Second Messenger Mechanisms.- 7 5-Hydroxytryptamine and Noradrenaline Synthesis, Release and Metabolism in the Central Nervous System: Circadian Rhythms and Control Mechanisms.- 8 Rhythms in Pharmacokinetics; Absorption, Distribution, Metabolism and Excretion.- 9 Progress in the Chronotherapy of Nocturnal Asthma.- 10 Chronopharmacology of Cardiovascular Diseases.- 11 Chronopharmacology of Anticancer Agents.- 12 The Endocrine System and Diabetes.- 13 Gastrointestinal Tract.- 14 The Pineal Gland, Circadian Rhythms and Photoperiodism.- 15 Problems in Interpreting the Effects of Drugs on Circadian Rhythms.- 16 Rhythms in Retinal Mechanisms.- 17 Circadian Rhythms and Depression: Clinical and Experimental Models.- 18 Chronobiology and Chronopharmacology of the Haemopoietic System.- 19 Chronobiology of the Haemostatic System.- 20 New Trends in Chronotoxicology.- 21 Chronopharmacology of H1-Receptor Antagonists: Experimental and Clinical Aspects (Allergic Diseases).- 22 Local Anaesthetics.- 23 Biological Rhythms in Pain and Analgesia.

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