Physiology of the Heart / Edition 4

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Overview

The Third Edition of this classic cardiac physiology text emphasizes the interrelationships of basic processes among cells, cardiac muscle function and the biophysics of contractile and electrical behavior. This edition of the critically acclaimed overview of cardiac function in health and disease has been revised to incorporate significant new concepts, expanded chapters on the ischemic heart and heart failure, and a revised illustration program. This book is a critical resource for cardiac physiology students, teachers, clinicians, and investigators.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Keith G Hickey, MD, BS (Ochsner Clinic Foundation)
Description: The first half of this remarkable single-authored textbook provides a detailed examination of the cellular, molecular and genetic processes involved in the physiology of the normal and diseased heart. The second half explains how these processes affect the function of heart as an entire organ, both in health and disease.
Purpose: This book presents the current understanding of the physiological and biophysical basis of cardiac function. This fourth edition examines both functional and proliferative signaling in great detail. In the last five years, abnormal proliferative signaling has emerged both as a major cause of heart disease and as a target for therapy.
Audience: Although written for students, residents, and clinicians, the book can also benefit basic scientists to relate a special area of research to the overall physiology of the heart. The goal is to help healthcare providers learn more about basic sciences, and basic scientists to learn more about how the heart works in health and disease.
Features: This book is divided into four parts. Part I reviews the structure, biochemistry, and biophysics of the normal heart. Part II contains three chapters covering regulation. Part III integrates the first two in describing the normal heart as a pump, and the electrical systems that control its beating. Lastly, part IV describes the pathophysiology of the three major types of heart disease, beginning with a review of the electrocardiogram and concluding with discussions of arrhythmias, ischemic heart disease, and heart failure.
Assessment: This fourth edition provides exactly what the author intended, a simple approach to complex issues intended to explain concepts to students, physicians, and scientists alike. Only Dr. Katz, with 40 to 50 years of experience as both a basic scientist and a clinical cardiologist, as well as a gifted teacher, could have completed this undertaking. He has dedicated his life to cardiac physiology, and this edition of his now classic text is the best yet.
Booknews
The first edition (1977) focused on the integration of organ physiology and cell biochemistry; the second adds new information about regulation by altered gene expression, for example, the ability of one protein isoform to replace another to adapt the energy-starved myocardium to the chronic overload commonly seen in patients with heart failure. The author's single-voice explains and integrates a broad range of topics from molecular biology to clinical cardiology. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780781755016
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 11/28/2005
  • Edition description: Fourth Edition
  • Edition number: 4
  • Pages: 640
  • Product dimensions: 6.20 (w) x 9.20 (h) x 1.40 (d)

Table of Contents

STRUCTURE, BIOCHEMISTRY, AND BIOPHYSICS

Structure of the Heart and Cardiac Muscle
Energetics and Energy Production
Energy Utilization (Work and Heat)
The Contractile Proteins
The Cytoskeleton
Active State, Length-Tension Relationship, and Cardiac Mechanics
Excitation-Contraction Coupling: Extracellular and Intracellular Calcium Cycles

SIGNAL TRANSDUCTION AND REGULATION

Signal Transduction: Functional Signaling
Signal Transduction: Proliferative Signaling
Regulation of Cardiac Muscle Performance: Functional and Proliferative Mechanisms

NORMAL PHYSIOLOGY

The Heart as a Muscular Pump
The Working Heart
Cardiac Ion Channels
The Cardiac Action Potential

CLINICAL PHYSIOLOGY

The Electrocardiogram
Arrhythmias
The Ischemic Heart
Heart Failure

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