The Physiology of Truth: Neuroscience and Human Knowledge (L'Homme de Verite)

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In this wide-ranging book, one of the boldest thinkers in modern neuroscience confronts an ancient philosophical problem: can we know the world as it really is?

Drawing on provocative new findings about the psychophysiology of perception and judgment in both human and nonhuman primates, and also on the cultural history of science, Jean-Pierre Changeux makes a powerful case for the reality of scientific progress and argues that it forms the basis for a coherent and universal theory of human rights. On this view, belief in objective knowledge is not a mere ideological slogan or a naïve confusion; it is a characteristic feature of human cognition throughout evolution, and the scientific method its most sophisticated embodiment. Seeking to reconcile science and humanism, Changeux holds that the capacity to recognize truths that are independent of subjective personal experience constitutes the foundation of a human civil society.

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Editorial Reviews

Changeux's work advances an 'epigenetic hypothesis' as a means of explaining the philosophical significance of recent findings in the neurosciences. This is especially noteworthy because the hypothesis offers an evidence-based challenge to two popular ideas: namely, the largely functionalist idea that the brain is nothing more than a sophisticated computer and, alternatively, the nativist idea that the brain is 'the embodiment of a strictly predetermined genetic inheritance.' Among Changeux's many conclusions, two are particularly fascinating: first, that the brain is able to produce objective knowledge--a kind of universal framework of thought--that permits individuals to communicate through language; and secondly, that this fact about the human species may serve as the basis by which humans ultimately save themselves.
— H. Storl
Nature Neuroscience
The Physiology of not an essay on physiology, epistemology or semantics, but a tour de force covering selected chapters in neuroscience and their philosophical underpinning, colored by the author's interpretation of the interaction of phylogenesis, ontogenesis and epigenesis. The binding theme is the relationship of knowledge encoded in our brain with the world at large. The theory draws from forty years of research by the author and his colleagues, but as usual, it also rests on the shoulders of giants...The Physiology of Truth is a useful pointer to intellectual repercussions of brain research, as well as the epitome of the ability to bring blessed subjectivity to scientific texts. Many discussions in the book are thought provoking.
— Yadin Dudai
New Scientist
[Changeux] thinks it is time that scientists attempted to explain mythic thought, because only by understanding irrational belief can they explain the rational search for truth that grew out of it. An objective knowledge does exist, and our brains are equipped to recognise it. But the quest for it is often biased by political and economic forces, and the editorial decisions of journals which are at the mercy of those forces.
— Laura Spinney
New York Review of Books
Jean-Pierre Changeux is France's most famous neuroscientist...In his book The Physiology of Truth, Changeux connects memory to the acquisition of knowledge and the testing of its validity, as is done in science in general.
— Israel Rosenfield and Edward Ziff
In The Physiology of Truth, a translation of his L'Homme de vérité, Jean-Pierre Changeux provides an account whereby selection among an initial plethora of possibilities yields those that are true, a process evident both in brain development and in knowledge acquisition. Along the way, he espouses a hopeful naturalism: evolution ensures that our nervous systems aim at representing the truth, and aspects of our culture--notably freedom, communication, and pursuit of the scientific method--can ensure that we as a society have true beliefs...Changeux, a neurobiologist at the Institut Pasteur in Paris, begins by reviewing the philosophical problems and their recalcitrance. He then considers the neurobiology and its complexity and lastly extends his discussion to culture and society...His vision is at once that of the detached scientist and the deeply caring humanist--for him, the two go hand in hand. He believes that applying the standards of the scientific method to society will promote freedom of ideas and individual rights, and that from this a stable consensual agreement on truth can emerge. Let us hope that this attractive vision prevails.
— Ralph Adolphs and James Woodward
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Product Details

  • ISBN-13: 9780674012837
  • Publisher: Harvard University Press
  • Publication date: 4/28/2004
  • Series: Mind/Brain/Behavior Initiative Series
  • Edition description: New Edition
  • Pages: 336
  • Product dimensions: 6.40 (w) x 9.46 (h) x 0.96 (d)

Meet the Author

Jean-Pierre Changeux, author of the classic Neuronal Man, is Director of the Molecular Neurobiology Laboratory at the Institut Pasteur in Paris, Professor in the Collège de France, and a member of the French Academy of Sciences.

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Table of Contents

Introduction 1
1 Thinking Matter 7
2 The Acquisition of Knowledge 39
3 States of Consciousness 71
4 Knowledge and Social Life 111
5 From Genes to Brain 152
6 Neuronal Epigenesis and Cultural Evolution 184
7 Scientific Research and the Search for Truth 211
8 The Humanity of Science 236
Conclusion 258
Notes 267
Credits 305
Acknowledgments 311
Index 313
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