The Pituitaryby Shlomo Melmed
The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a
The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary.
The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing.
The first chapter will be completely new – placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years – from new advances in growth hormones to pituitary tumor therapy.
- Presents a comprehensive, translational source of information about the pituitary in one reference work
- Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches
- Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders
- Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches
Description: This multiauthored text is intended to encompass the biochemistry, molecular biology, physiology, pathophysiology, and clinical aspects of both the anterior and posterior pituitary.
Purpose: The text is divided into five sections: hypothalamic-pituitary function; hypothalamic-pituitary dysfunction; pituitary tumors; pituitary disease in systemic disorders; and diagnostic procedures. This structure, as well as the fact that the clinical and basic chapters within a given area (e.g., ACTH secretion) are authored by different individuals, artificially separates the clinical from the basic science aspects of pituitary disease. This structure also leads to significant redundancy in the text. On balance, there is a lesser emphasis on clinical aspects of pituitary disease.
Audience: The author wishes the text to serve the internist, obstetrician/gynecologist, and pediatrician at any level of training.
Features: The illustrations are generally good, but are too few in number. Color illustrations are lacking and photomicrographs are often poorly reproduced. The references are up-to-date and adequate in number. Although the topic of the clinically nonfunctioning pituitary tumor is discussed in the chapter on gonadotroph adenomas, this is not clear from the table of contents or the index. The most useful section of the book includes a discussion of the pituitary in pregnancy, the effect of eating disorders on pituitary function, and the effect of medications on pituitary function. Finally, the appendix of the evaluation of pituitary function is useful.
Assessment: Although there are several unique and useful features of this book, it will not entirely satisfy either clinician or basic scientist. Given the plethora of excellent textbooks of endocrinology that include most of what is covered here, there seems to be no obvious advantage to including this book in one's library.
- Elsevier Science
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Meet the Author
Dr. Melmed co-edits Endocrinology: Basic and Clinical Principles, is the Neuroendocrine Section Editor for DeGroot and Jameson's Textbook of Endocrinology, and Williams Textbook of Endocrinology; and is pituitary section author for Harrison's Textbook of Medicine. In addition to being the Editor-in-Chief of Pituitary, he is on the editorial board of Journal of Clinical Investigation and past Editor-in-Chief of Endocrinology.
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