Placental Pharmacology / Edition 1

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1996 Hard cover New. Sewn binding. Cloth over boards. 224 p. CRC Pharmacology & Toxicology: Basic & Clinical Aspects. Audience: General/trade. BRAND NEW. gift quality. ... (shrinkwrap) NO DJ, as issued. Read more Show Less

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Overview

Placenta plays a very significant role in the development of secretory and regulatory functions for the maintenance of pregnancy and in the nutrition of the embryo. It shares many functions of the heart, lung, liver, endocrines, and other organs. In Placental Pharmacology, fourteen expert authors discuss how placenta and its component parts can be used effectively in drug development research and in the study of transfer mechanisms across membranes.
This reference begins by describing the use of modern biophysical methods to study placental function and prospects for their application in pharmacological research. The next three chapters deal with placental hemodynamics, use of placental tissues and cells in pharmacological assays, and placental transfer of drugs used in pregnancy. Three more chapters contain up-to-date information on molecular biological aspects of placenta currently receiving lots of attention - phospholipase A2 isozymes, imprinted genes and embryogenesis, and placental growth factors. The final chapter describes the clinically relevant topics of placental metabolism and toxicity of homocysteine in placenta.
Easy to understand, thorough, and complete, Placental Pharmacology is the perfect resource for scientists interested in placenta and its uses in drug development and testing.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

From The Critics
Reviewer: Edmund W. Quillen, Jr., MD (University of Illinois at Chicago College of Medicine)
Description: This book provides a general description of ways the placenta can be used in pharmacologic research together with appropriate physiologic background.
Purpose: The book purports to provide information on different ways the placenta can be used in investigation of mechanisms of drug and chemical transfer across the placenta. The book was not intended as a comprehensive treatise but rather as a useful monograph for scientists of different disciplines.
Audience: This book is appropriate for either scientists or students of any discipline interested in placental research. The editor and authors are all expert in a variety of aspects of placental function, so a reasonably broad review of placental pharmacology and physiology is provided.
Features: The book is well illustrated and referenced. Although the references are numerous, many are older, possibly reflecting the need for more current work. Each chapter is preceded by a contents listing, and most chapters are concluded with a summary section. The book has an overall good appearance, but the cover is bland. The book has pages with color Doppler and colored computerized image analyses of in situ hybridized slides.
Assessment: This book is useful to the researcher who has a background in placental function, but it is even more valuable as an introduction to investigators new to this field. The book was intended to present methodologic approaches to studies of placental function, but only two of its eight chapters are so oriented. Nevertheless, the reviews of techniques, drug transfer, and endocrine function make the book a worthwhile addition to both library and personal collections.
Edmund W. Quillen
This book provides a general description of ways the placenta can be used in pharmacologic research together with appropriate physiologic background. The book purports to provide information on different ways the placenta can be used in investigation of mechanisms of drug and chemical transfer across the placenta. The book was not intended as a comprehensive treatise but rather as a useful monograph for scientists of different disciplines. This book is appropriate for either scientists or students of any discipline interested in placental research. The editor and authors are all expert in a variety of aspects of placental function, so a reasonably broad review of placental pharmacology and physiology is provided. The book is well illustrated and referenced. Although the references are numerous, many are older, possibly reflecting the need for more current work. Each chapter is preceded by a contents listing, and most chapters are concluded with a summary section. The book has an overall good appearance, but the cover is bland. The book has pages with color Doppler and colored computerized image analyses of in situ hybridized slides. This book is useful to the researcher who has a background in placental function, but it is even more valuable as an introduction to investigators new to this field. The book was intended to present methodologic approaches to studies of placental function, but only two of its eight chapters are so oriented. Nevertheless, the reviews of techniques, drug transfer, and endocrine function make the book a worthwhile addition to both library and personal collections.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780849378119
  • Publisher: CRC Press
  • Publication date: 5/6/1996
  • Series: Handbooks in Pharmacology and Toxicology Series , #36
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 224
  • Product dimensions: 7.30 (w) x 10.20 (h) x 0.70 (d)

Table of Contents

Techniques: Biophysical Methods for Assessment of Placental Function, M. Panigel, J.S. Abramowicz and R.K. Miller
Factors Regulating Placental Hemodynamics, N.M. Gude, R.G. King and S.P. Brennecke
Techniques: Cultured Tissues and Cells to Study Placental Function, B.V. Rama Sastry
Drugs Used in Pregnancy and Their Placental Transfer, S. Mouton
Placental Phospholipases A2 Isozymes, G.E. Rice
The Role of Imprinted Genes in Human Embryogenesis, Placental Development, and Tumorigenesis, M.L. Glassman, N. de Groot and A. Hochberg
Placental Growth Factors, M.E. Fant
Metabolism and Toxicity of Homocysteine in Placenta, A.W. Toos Goddijn-Wessel
Index

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