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Platelet Function: Assessment, Diagnosis, and Treatment / Edition 1
     

Platelet Function: Assessment, Diagnosis, and Treatment / Edition 1

by Martin Quinn, Desmond Fitzgerald, Dermott Cox
 

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ISBN-10: 1617374474

ISBN-13: 9781617374470

Pub. Date: 11/09/2010

Publisher: Springer-Verlag New York, LLC

Platelet function, or clot formation, is difficult to assess, but extremely important because inadvertent or excessive platelet activation underlies many common cardiovascular disorders, such as myocardial infarction, unstable angina, and stroke. In Platelet Function: Assessment, Diagnosis, and Treatment, a panel of leading researchers and clinicians review the

Overview

Platelet function, or clot formation, is difficult to assess, but extremely important because inadvertent or excessive platelet activation underlies many common cardiovascular disorders, such as myocardial infarction, unstable angina, and stroke. In Platelet Function: Assessment, Diagnosis, and Treatment, a panel of leading researchers and clinicians review the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.

Comprehensive and state of the art, Platelet Function: Assessment, Diagnosis, and Treatment offers vascular researchers and clinicians a sound foundation for understanding platelet biology, assessing thrombotic risk in patients, and determining the rational dosing of antiplatelet agents.

Product Details

ISBN-13:
9781617374470
Publisher:
Springer-Verlag New York, LLC
Publication date:
11/09/2010
Series:
Contemporary Cardiology Series
Edition description:
Softcover reprint of hardcover 1st ed. 2005
Pages:
398
Product dimensions:
5.98(w) x 9.02(h) x 0.03(d)

Related Subjects

Table of Contents

Part I. Platelet Physiology

Platelet Physiology
Martin Quinn

Platelet Integrins and Signaling
Karlheinz Peter

Platelet Adhesion
Brian Savage and Zaverio M. Ruggeri

Structure-Function of the Platelet Cytoskeleton
Elaine L. Bearer

Platelets and Inflammation
Meinrad Gawaz

Platelet Signal-Dependent Protein Synthesis
Stephan Lindemann, Thomas M. McIntyre, Stephen M. Prescott, Guy A. Zimmerman, and Andrew S. Weyrich

Phosphoproteomics of Human Platelets
Katrin Marcus and Helmut E. Meyer

Part II. Assessing Platelet Function

Platelet Function Studies
Dermot Cox

Platelet Function Under Flow
José A. López, Ian del Conde, and Jing-Fei Dong

Pharmacodynamics of GPIIb-IIIa Receptor Blockade
Lisa K. Jennings and Melanie M. White

Prostanoid Generation in Platelet Function: Assessment and Clinical Relevance
Bianca Rocca and Carlo Patrono

Platelets and Prothrombin
Michael Kalafatis, Emil Negrescu, Tatiana Byzova, and Edward F. Plow

Markers of Platelet Activation and Granule Secretion
Alan D. Michelson and Mark I. Furman

Genomic and Proteomic Analysis of Platelets: Clinical Applications
Andrew Maree and James McRedmond

Part III. Clinical Applications

Antiplatelet Agents
Jacqueline Saw and David J. Moliterno

Assessing Platelet Function in Clinical Trials
Neal Kleiman

Index

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