Platelet Function: Assessment, Diagnosis, and Treatment / Edition 1

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Platelet function, or clot formation, is difficult to assess, but extremely important because inadvertent or excessive platelet activation underlies many common cardiovascular disorders, such as myocardial infarction, unstable angina, and stroke. In Platelet Function: Assessment, Diagnosis, and Treatment, a panel of leading researchers and clinicians review the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.

Comprehensive and state of the art, Platelet Function: Assessment, Diagnosis, and Treatment offers vascular researchers and clinicians a sound foundation for understanding platelet biology, assessing thrombotic risk in patients, and determining the rational dosing of antiplatelet agents.

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Editorial Reviews

From the Publisher
From the reviews:

" outstanding book for those who want a concise review of platelet function and its relevance to thrombotic disorders and current pharmacology." - Circulation

"...a very useful book for anyone interested in the fundamentals of platelet function, platelet biomarkers, techniques for activation measurement, and thrombotic disorders." - Circulation

"This book is directed to the attention of clinicians practicing clinical and or laboratory medicine, basic scientists interested in platelet physiology, pharmocologists focusing on cardiovascular drugs, and teachers of medical students and physicians in training. … The most advanced investigative techniques are presented in separate chapters to explore platelet membrane receptors, signal-dependant translation in platelets and for identifying products that regulate thrombosis and inflammation. … a relatively small book, but with 397 pages of pertinent and practical knowledge from major professionals in the field." (Harry L. Messmore and William H. Wehrmacher, Clinical and Applied Thrombosis/Hemostasis, Vol. 12 (1), January, 2006)

Doody's Review Service
Reviewer: Anaadriana Zakarija, MD (Northwestern University Feinberg School of Medicine)
Description: This book provides a summary of platelet structure and function and methods of assessment of platelet function. The clinical implications of platelet function and inhibition are discussed as they relate primarily to cardiovascular disorders.
Purpose: The primary objectives are to present current information on platelet biology, function, and clinical implications. This understanding is important as the use of antiplatelet therapy increases. The book does an excellent job of separating the different components of platelet function and presenting them in a manner that is easy to understand. The discussion of clinically relevant platelet disorders is limited in this book, with the primary focus on cardiovascular disorders.
Audience: The authors have designed the book to reach a wide audience — from scientists involved in platelet biology to physicians involved in clinical practice. The book provides an excellent background on platelet function to this group. However, clinicians will not find an in-depth review of platelet disorders and their management in this book.
Features: The first section offers a comprehensive review of platelet physiology, including excellent chapters on platelet cytoskeleton, integrins and the various platelet receptors. The information is very current, and there is even a discussion of the evolving field of proteomics as it relates to platelet research. Methods of assessing platelet function are described, but the review has limited clinical applicability. The book does not focus on highlighting platelet disorders and how testing should be used in a diagnostic algorithm. For example, actual platelet aggregometry curves that are representative of classic platelet disorders would have been informative. The title implies a comprehensive review of platelet function disorders including treatments of such, but this is not the case. Platelet disorders such as Bernard-Soulier and Glanzmann's thrombasthenia are briefly discussed, but other disorders such as storage pool disorders are not mentioned. The clinical focus of the book is on the platelet's role in cardiovascular disorders and the use of antiplatelet therapy. This aim is achieved by a good summary of this topic.
Assessment: This book is a good resource for s scientists and clinicians as it provides a summary of the current knowledge of platelet biology. It is not a good source for those looking to diagnose and treat patients with platelet disorders.
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Product Details

  • ISBN-13: 9781617374470
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/9/2010
  • Series: Contemporary Cardiology Series
  • Edition description: Softcover reprint of hardcover 1st ed. 2005
  • Edition number: 1
  • Pages: 398
  • Product dimensions: 5.98 (w) x 9.02 (h) x 0.84 (d)

Table of Contents

Part I. Platelet Physiology

Platelet Physiology
Martin Quinn

Platelet Integrins and Signaling
Karlheinz Peter

Platelet Adhesion
Brian Savage and Zaverio M. Ruggeri

Structure-Function of the Platelet Cytoskeleton
Elaine L. Bearer

Platelets and Inflammation
Meinrad Gawaz

Platelet Signal-Dependent Protein Synthesis
Stephan Lindemann, Thomas M. McIntyre, Stephen M. Prescott, Guy A. Zimmerman, and Andrew S. Weyrich

Phosphoproteomics of Human Platelets
Katrin Marcus and Helmut E. Meyer

Part II. Assessing Platelet Function

Platelet Function Studies
Dermot Cox

Platelet Function Under Flow
José A. López, Ian del Conde, and Jing-Fei Dong

Pharmacodynamics of GPIIb-IIIa Receptor Blockade
Lisa K. Jennings and Melanie M. White

Prostanoid Generation in Platelet Function: Assessment and Clinical Relevance
Bianca Rocca and Carlo Patrono

Platelets and Prothrombin
Michael Kalafatis, Emil Negrescu, Tatiana Byzova, and Edward F. Plow

Markers of Platelet Activation and Granule Secretion
Alan D. Michelson and Mark I. Furman

Genomic and Proteomic Analysis of Platelets: Clinical Applications
Andrew Maree and James McRedmond

Part III. Clinical Applications

Antiplatelet Agents
Jacqueline Saw and David J. Moliterno

Assessing Platelet Function in Clinical Trials
Neal Kleiman


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