Platelet Proteomics: Principles, Analysis, and Applications / Edition 1

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The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.

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Editorial Reviews

From the Publisher
"Experienced researchers looking for an up-to-date and comprehensive review of this rapidly developing field will find this book a valuable resource.” (American Society for Mass Spectrometry, 13 December 2011)
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Product Details

Meet the Author

Dr. Ángel García is currently a Ramón y CajalResearch Fellow at the Pharmacology Department, Universidade deSantiago de Compostela, Spain His main research is the area ofplatelet proteomics, with special emphasis in cardiovascularresearch and platelet signaling studies. He has written over twentypublications in peer-reviewed journals and has been an invitedlecturer at the Platelets 2010 International Symposium (Jerusalem,Israel), and the XXII Congress of the International Society onThrombosis and Haemostasis, held in Boston, United States, in 2009,where he chaired a session on novel approaches to understandingplatelet biology. Sr. Garcia was a postdoctoral research associateof the Proteomics Group at the Oxford Glycobiology Institute,University of Oxford ((UK), from 2001 to 2005.

Dr. Yotis Senis  is currently a British HeartFoundation Research Fellow at the University of Birmingham, UnitedKingdom. He is a senior member of the Birmingham Platelet Group.Dr. Senis’ research interests include the identification ofnovel platelet surface glycoproteins and determining theirbiological and molecular functions. He is also interested in thefunctional roles of protein tyrosine phosphatases in platelets andthrombosis. Dr. Senis has been an invited lecturer at the 2010International Symposium (Jerusalem, Israel) and the Gordon ResearchConference on the Cell Biology of Megakaryocytes and Platelets(Galveston, Texas). He has written over twenty publications onplatelet signaling and thrombosis.

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Table of Contents






1 Platelets and Their Role in Thrombotic and CardiovascularDisease: The Impact of Proteomic Analysis (Ronald G. Stanley,Katherine L. Tucker, Natasha E. Barrett, and Jonathan M.Gibbins).

2 Mass-Spectrometry-Based Proteomics: General Overview andPosttranslational Modification Analysis in the Context of PlateletResearch (Julia Maria Burkhart and Albert Sickmann).

3 Sample Preparation Variables in Platelet Proteomics forBiomarker Research (Maria Zellner and Rudolf Oehler).


4 Two-Dimensional Gel Electrophoresis: Basic Principles andApplication to Platelet Signaling Studies (AngelGarcia).

5 The Platelet Membrane Proteome (Yotis A. Senis).

6 Proteomics of Platelet Granules, Organelles, and Releasate(James P. McRedmond).

7 The Platelet Microparticle Proteome (David M.Smalley).

8 N-Terminal Combined Fractional Diagonal Chromatographic(COFRADIC) Analysis of the Human Platelet Proteome (FrancisImpens, Kenny Helsens, Niklaas Colaert, Lennart Martens, JoelVandekerckhove, and Kris Gevaert).


9 Serial Analysis of Gene Expression (SAGE) For Studying thePlatelet and Megakaryocyte Transcriptome (Michael G.Tomlinson).

10 The Application of Microarray Analysis and Its Integrationwith Proteomics for Study of Platelet-Associated Disorders(Dmitri V. Gnatenko and Wadie F. Bahou).

11 Platelet Functional Genomics (Isabelle I. Salles, Marie N.O’Connor, Daphne C. Thijssen-Timmer, Katleen Broos, and HansDeckmyn).

12 Systems Biology to Study Platelet-Related Bleeding Disorders(Jan-Willem N. Akkerman and Bernard De Bono).

13 Platelet Proteomics in Transfusion Medicine (ThomasThiele, Leif Steil, Uwe Vólker, and AndreasGreinacher).

14 Cardiovascular Proteomics (Fernando Vivanco, Fernando dela Cuesta, Maria G. Barderas, Irene Zubiri, and GloriaA´lvarez-Llamas).


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