Platelet Proteomics: Principles, Analysis, and Applications / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$103.63
Used and New from Other Sellers
Used and New from Other Sellers
from $60.38
Usually ships in 1-2 business days
(Save 44%)
Other sellers (Hardcover)
  • All (10) from $60.38   
  • New (5) from $80.99   
  • Used (5) from $60.36   

Overview

The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.

Read More Show Less

Editorial Reviews

From the Publisher
"Experienced researchers looking for an up-to-date and comprehensive review of this rapidly developing field will find this book a valuable resource.” (American Society for Mass Spectrometry, 13 December 2011)
Read More Show Less

Product Details

Meet the Author

Dr. Ángel García is currently a Ramón y CajalResearch Fellow at the Pharmacology Department, Universidade deSantiago de Compostela, Spain His main research is the area ofplatelet proteomics, with special emphasis in cardiovascularresearch and platelet signaling studies. He has written over twentypublications in peer-reviewed journals and has been an invitedlecturer at the Platelets 2010 International Symposium (Jerusalem,Israel), and the XXII Congress of the International Society onThrombosis and Haemostasis, held in Boston, United States, in 2009,where he chaired a session on novel approaches to understandingplatelet biology. Sr. Garcia was a postdoctoral research associateof the Proteomics Group at the Oxford Glycobiology Institute,University of Oxford ((UK), from 2001 to 2005.

Dr. Yotis Senis  is currently a British HeartFoundation Research Fellow at the University of Birmingham, UnitedKingdom. He is a senior member of the Birmingham Platelet Group.Dr. Senis’ research interests include the identification ofnovel platelet surface glycoproteins and determining theirbiological and molecular functions. He is also interested in thefunctional roles of protein tyrosine phosphatases in platelets andthrombosis. Dr. Senis has been an invited lecturer at the 2010International Symposium (Jerusalem, Israel) and the Gordon ResearchConference on the Cell Biology of Megakaryocytes and Platelets(Galveston, Texas). He has written over twenty publications onplatelet signaling and thrombosis.

Read More Show Less

Read an Excerpt

catalogimages.wiley.com/images/db/pdf/9780470463376.excerpt.pdf
Read More Show Less

Table of Contents

Contributors.

Foreword.

Preface.

Acronyms.

PART I GENERAL OVERVIEW: PLATELETS, SAMPLE PREPARATION, ANDMASS SPECTROMETRY-BASED PROTEOMICS.

1 Platelets and Their Role in Thrombotic and CardiovascularDisease: The Impact of Proteomic Analysis (Ronald G. Stanley,Katherine L. Tucker, Natasha E. Barrett, and Jonathan M.Gibbins).

2 Mass-Spectrometry-Based Proteomics: General Overview andPosttranslational Modification Analysis in the Context of PlateletResearch (Julia Maria Burkhart and Albert Sickmann).

3 Sample Preparation Variables in Platelet Proteomics forBiomarker Research (Maria Zellner and Rudolf Oehler).

PART II ANALYSIS OF THE PLATELET PROTEOME: GLOBALAPPROACHES AND SUBPROTEOMES.

4 Two-Dimensional Gel Electrophoresis: Basic Principles andApplication to Platelet Signaling Studies (AngelGarcia).

5 The Platelet Membrane Proteome (Yotis A. Senis).

6 Proteomics of Platelet Granules, Organelles, and Releasate(James P. McRedmond).

7 The Platelet Microparticle Proteome (David M.Smalley).

8 N-Terminal Combined Fractional Diagonal Chromatographic(COFRADIC) Analysis of the Human Platelet Proteome (FrancisImpens, Kenny Helsens, Niklaas Colaert, Lennart Martens, JoelVandekerckhove, and Kris Gevaert).

PART III INTEGRATED "OMICS" AND APPLICATIONTO DISEASE.

9 Serial Analysis of Gene Expression (SAGE) For Studying thePlatelet and Megakaryocyte Transcriptome (Michael G.Tomlinson).

10 The Application of Microarray Analysis and Its Integrationwith Proteomics for Study of Platelet-Associated Disorders(Dmitri V. Gnatenko and Wadie F. Bahou).

11 Platelet Functional Genomics (Isabelle I. Salles, Marie N.O’Connor, Daphne C. Thijssen-Timmer, Katleen Broos, and HansDeckmyn).

12 Systems Biology to Study Platelet-Related Bleeding Disorders(Jan-Willem N. Akkerman and Bernard De Bono).

13 Platelet Proteomics in Transfusion Medicine (ThomasThiele, Leif Steil, Uwe Vólker, and AndreasGreinacher).

14 Cardiovascular Proteomics (Fernando Vivanco, Fernando dela Cuesta, Maria G. Barderas, Irene Zubiri, and GloriaA´lvarez-Llamas).

Index.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)