Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook / Edition 1

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A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of hematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.

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Editorial Reviews

From the Publisher
"A comprehensive clinical handbook...Each aspect of the platelet is covered in detail by leading experts in the field...The first 19 chapters contain a good mix of basic science and clinical medicine...The last seven chapters of the book cover [the development of antiplatelet drugs] in great detail. Tables and graphs summarizing the main clinical trials of antiplatelet therapy complement the information and recommendations presented in these treatment-oriented chapters...I enjoyed reading this book and believe that it will be a useful guide for residents, graduate students, physicians, and scientists."
—New England Journal of Medicine
Doody's Review Service
Reviewer: Chandra S. Bomma, M.D.(Ochsner Clinic Foundation)
Description: This comprehensive update relates recent developments regarding platelets and their role in hematological and cardiovascular diseases.
Purpose: The intention was to bring together a book on platelet function, including synthesis, activation, diagnostics, and therapeutic options for various hematological and cardiovascular disorders relating to structural and functional disorders of platelets.
Audience: This could be an excellent source of knowledge for medical students, residents/fellows and clinicians interested in hematological, cardiovascular, and inflammatory diseases.
Features: Laboratory diagnostic testing, the clinical approach to the bleeding patient, platelet transfusion therapy, and antiplatelet therapy in cardiovascular disease are discussed in detail. The book includes excellent illustrations, schematics, flow charts, "take home message" sections, and references to support the facts in this book.
Assessment: In recent years, a large body of scientific knowledge has been acquired on the role of platelets in hematological and cardiovascular diseases. This is a well done composition by qualified authors.
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Product Details

  • ISBN-13: 9780521881159
  • Publisher: Cambridge University Press
  • Publication date: 12/28/2007
  • Edition number: 1
  • Pages: 526
  • Product dimensions: 7.44 (w) x 9.69 (h) x 1.18 (d)

Meet the Author

Paolo Gresele is a Professor of Internal Medicine at the University of Perugia, Italy.

Valentin Fuster is the Director of Mount Sinai Heart School of Medicine, New York.

José A. López is the Executive Vice President for Research at the University of Seattle, Washington.

Clive P. Page is a Professor of Pharmacology at King's College London.

Jos Vermylen is an Emeritus Professor of Medicine at the University of Leuven, Belgium.

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Table of Contents

Preface; 1. The structure and production of blood platelets Joseph E. Italiano, Jr; 2. Platelet immunology: structure, functions and polymorphisms of membrane glycoproteins Yasuo Ikeda, Yumiko Matsubara and Tetsuji Kamata; 3. Mechanisms of platelet activation Lawrence Brass and Timothy J. Stalker; 4. Platelet priming Paolo Gresele, Emanuela Dalcinelli and Stafania Momi; 5. Platelets and coagulation José A. López and Ian del Conde; 6. Vessel-wall-derived substances affecting platelets Azad Raiesdana and Joseph Loscalzo; 7. Platelet-Leukocyte-Endothelial cross talk Kevin J. Croce, Masashi Sakuma and Daniel I. Simon; 8. Laboratory investigation of platelets Eduard Shantsila, Timothy Watson and Gregory Y. H. Lip; 9. Clinical approach to the bleeding patient Jos Vermylen and Kathelijne Peerlinck; 10. Thrombocytopenia James Bussel and Andrea Primiani; 11. Reactive and clonal thrombocytosis Ayalew Tefferi; 12. Congenital disorders of platelet function Marco Cattaneo; 13. Acquired disorders of platelet function Michael H. Kroll and Amy A. Hassan; 14. Platelet transfusion therapy Sherrill J. Slichter and Ronald G. Strauss; 15. Clinical approach to the patient with thrombosis Brian G. Choi and Valentin Fuster; 16. Pathophysiology of arterial thrombosis Juan José Badimon, Borja Ibanez and Gemma Vilahur; 17. Platelets and atherosclerosis Stephan Lindemann and Meinrad Gawaz; 18. Platelets in other thrombotic conditions David L. Green, Peter W. Marks and Simon Karpatkin; 19. Platelets in respiratory disorders and inflammatory conditions Paolo Gresele, Stefania Momi, Simon C. Pitchford and Clive P. Page; 20. Platelet pharmacology Dermot Cox; 21. Antiplatelet therapy versus other antithrombotic strategies Nicolai Mejevoi, Catalin Boiangiu and Marc Cohen; 22. Laboratory monitoring of antiplatelet therapy Paul Harrison and David Keeling; 23. Antiplatelet therapy in cardiology Pierluigi Tricoc and Robert A. Harrington; 24. Antiplatelet therapy in cerebrovascular disease James Castle and Gregory W. Albers; 25. Antiplatelet treatment in peripheral arterial disease Raymond Verhaeghe and Peter Verhamme; 26. Antiplatelet treatment of venous thromboembolism Menno V. Huisman, Jaapjan D. Snoep, Jouke T. Tamsma and Marcel M. C. Hovens; Index.

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