Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics

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This book reviews current science and applications of platelets research in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis and therapeutics of diseases involving platelets. Chapters are devised to provide a critical review of the most clinically relevant aspects of the subject.

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Editorial Reviews

Doody's Review Service
Reviewer: Lisa Boggio, MS, MD (Northwestern University Feinberg School of Medicine)
Description: Revealing the mystery of platelets — this is an excellent guide to the physiology and pathology of platelets. There are detailed chapters with information on platelet testing and on drugs that are used to alter platelet function. The book ends with descriptions of several diseases, the role platelets play in them, and the treatment options.
Purpose: There is increasing evidence that platelets play major roles in thrombotic disorders such as stroke, peripheral vascular disease, and myocardial infarction; platelets also are implicated in cancer and infection. Disorders of platelets or alteration in their number cause significant morbidity, but the pathophysiology of platelets is largely a mystery to clinicians. Understanding this cytoplasmic fragment can lead to great improvements in the care and prevention of disease.
Audience: This book is meant for researchers or clinicians who work with platelets or their related diseases. Cardiologists, neurologists, vascular surgeons, and hematologists will have a special interest in this book, although general practitioners who touch upon these areas may also use it.
Features: The book begins with a detailed look at the physiology of platelets. By taking each component and examining it completely, the full spectrum of platelet function can be ascertained. Commonly used laboratory evaluations for platelets are described and then the pathologic abnormalities of platelets including thrombotic and bleeding disorders are discussed. The myriad of drugs used to affect platelet function are described well with discussions of cardiac, neurologic, and vascular conditions completing the offering.
Assessment: Such a comprehensive collection of platelet structure, function, and pathology has not been achieved before. This is the complete, comprehensive reference for platelets and it is invaluable to anyone who is involved in the treatment or the study of conditions related to platelets.
From the Publisher
"The four editors have managed very well in having internationally renowned investigators reviewing their particular fields of interest related to platelet research and the result is a beautiful piece of work! I strongly recommend this book to those involved in medicine in general and vascular medicine and hemostasis and thrombosis research in particular!" H. ten Cate, Pathophysiology of Haemostasis and Thrombosis

"...provides a comprehensive, up-to-date and detailed insight into platelet biology...all the chapters are well written by leaders in their field...this book serves as an invaluable reference source and is a 'must have' for postgraduate students, clinicians and researchers, whether relative novices or experts in the field." Transfusion Medicine

"[A] landmark in hematology...comprehensive coverage of platelet biology and pathology. The editors have assembled the best authors, and the authors have all provided thorough reviews with comprehensive, current citations." The New England Journal of Medicine

"Such a comprehensive collection of platelet structure, function, and pathology has not been achieved before. This is the complete, comprehensive reference for platelets and it is invaluable to anyone who is involved in the treatment or the study of conditions related to platelets." Doody's Review Service

"There has been no comprehensive, timely, and authoritative reference book covering the subject in recent years. Platelets in Thrombotic and Non-thrombotic Disorders fills this gap by providing a book that is both detailed and exhaustive yet easily consulted for the latest developments." Chest

"Obligatory reading for anyone who wishes to embark on platelet studies." International Society on Thrombosis and Haemostasis

" Platelets in Thrombiotic and Non-thrombiotic Disorders is an highly informative and extensively referenced textbook that is highly recommended..." Immunohematology

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780521802611
  • Publisher: Cambridge University Press
  • Publication date: 5/28/2002
  • Pages: 1124
  • Sales rank: 1,087,611
  • Product dimensions: 8.62 (w) x 10.87 (h) x 2.60 (d)

Meet the Author

Paolo Gresele is Guest Professor of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Italy

Clive Page is Professor of Pharmacology at the Sackler Institute of Pulmonary Pharmacology and Therapeutics, Guy's, King's and St Thomas' School of Biomedical Sciences, London

Jos Vermylen is Professor of Internal Medicine, University of Leuven, Belgium

Valentin Fuster is Professor of Medicine, Mount Sinai Medical Center and School of Medicine, New York

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Table of Contents

Prologue; Part I. Physiology: 1. History of platelets; 2. Production of platelets; 3. Morphology and ultrastructure of platelets; 4. Platelet heterogeneity: physiology and pathological consequences; 5. Platelet membrane proteins as adhesion receptors; 6. Dynamics of the platelet cytoskeleton; 7. Platelet organelles; 8. Platelet receptors for thrombin; 9. Platelet receptors: ADP; 10. Platelet receptors: prostanoids; 11. Platelet receptors: collagen; 12. Platelet receptors: von Willebrand factor; 13. Platelet receptor: fibrinogen; 14. Platelet signalling: GTP-binding proteins; 15. Platelet phospholipases A2; 16. Roles of phospholipase C and phospholipase D in receptor-mediated platelet activation; 17. Platelet signalling: calcium; 18. Platelet signalling: protein kinase; 19. Platelet signalling: tyrosine kinases; 20. Platelet signalling: cAMP and cGMP; 21. Platelet adhesion; 22. The platelet shape change; 23. Aggregation; 24. Amplification loops: release reaction; 25. Amplification loops: thromboxane generation; 26. Platelet procoagulant activities: the amplification loops between platelets and the plasmatic clotting system; 27. Platelets and chemotaxis; 28. Platelet–leukocyte interactions relevant to vascular damage and thrombosis; 29. Vascular control of platelet function; Part II. Methodology: 30. In vitro assays for evaluating platelet functions; 31. Monitoring antiplatelet therapy; 32. Flow cytometric analysis of platelets function; 33. Animal models of platelet-dependent thrombosis; Part III. Pathology: A. Hemostasis: 34. Hereditary thrombocytopenias; 35. Thrombocytopenias due to bone marrow disorders; 36. Immune mediated thrombocytopenia; 37. Thrombocytopenia in childhood; 38. Alloimmune thrombocytopenia; 39. Drug-induced and drug-dependent immune thrombocytopenias; 40. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome; 41. Thrombocytosis and thrombocythemia; 42. Platelet adhesive protein defect disorders; 43. Congenital disorders of platelet secretion; 44. Congenital platelet signal transduction defects; 45. Acquired platelet function defects; 46. Platelet storage and transfusion; B. Thrombosis: 47. Phatophysiology of arterial thrombosis; 48. Platelets and atherosclerosis; 49. Platelet involvement in venous thrombosis and pulmonary embolism; 50. Gene regulation of platelet function; C. Non-hemostatic disorders: 51. Platelets and bacterial infections; 52. Interactions of viruses and platelets and the inactivation of viruses in platelet concentrates prepared for transfusion; 53. Platelets and parasites; 54. Platelets and tumours ; 55. Platelets and renal diseases; 56. Platelets and allergic diseases; 57. Platelet interactions with other cells related to inflammatory diseases; 58. Platelets and the preimplantation stage of embryo development; 59. Platelet in psychiatric and neurological disorders; 60. Platelets in inflammatory bowel disease; Part IV. Pharmacology: 61. Aspirin; 62. Pharmacology of ticlopidine clopidogrel; 63. Platelet membrane glycoprotein (GP) IIb1–IIIa antagonists and acute arterial thrombosis; 64. Other antiplatelet agents; 65. Pharmacogenetics as a new antiplatelet strategy; 66. Cardiovascular gene therapy: implications for platelet vessel wall interactions; 67. Pharmacological modulation of the inflammatory actions of platelets; Part V. Therapy: 68. Design of trials to evaluate antiplatelet agents; 69. Antiplatelet therapy in cardiology; 70. Antiplatelet therapies in neurology; 71. Antiplatelet treatment in peripheral vascular disease.

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