Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications / Edition 1

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More About This Textbook


The platinum-containing chemotherapeutic agents remain key components of many of the most effective regimens for the treatment of cancer. New information about the chemistry, pharmacology and molecular mechanisms by which these drugs work is leading to both the development of new drugs and more effective use of existing members of this class. Better definition of the genetic basis of malignancies is offering intriguing new insights in to how to use these drugs in a more individualized manner. "Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications", edited by Andrea Bonetti, Steve B. Howell, Roberto Leone, and Franco Muggia, provides succinct summaries of the major new developments in field of platinum drug therapy drawn from presentations made at the 10th International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy that took place in Verona, Italy, in December 2007. This meeting, held once every 4 years, brought together the world’s leading investigators working on platinum drugs and their contributions provide a detailed survey of the major research directions in this rapidly evolving field.

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Product Details

  • ISBN-13: 9781603274586
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/16/2008
  • Series: Cancer Drug Discovery and Development Series
  • Edition description: 2009
  • Edition number: 1
  • Pages: 383
  • Product dimensions: 6.30 (w) x 9.30 (h) x 1.00 (d)

Table of Contents

Platinum chemotherapy: an oncologic success story Lawerence H. Einhorn Platinum compounds in clinical development Hilary Calvert Satraplatin: overview Cristiana Sessa Satraplatin in prostate cancer Cora Sternberg New formulations Roman Perez-Soler Novel drug delivery systems: AP5346 Stephen B. Howell CTR1 as a determinant of platinum drug transport Stephen B. Howell ATP7B regulates intracellular sequestration of Pt drugs Rouhi Safaei Molecular alterations of oxaliplatin-resistant cell exhibiting accumulation defects Paola Perego How to overcome cisplatin resistance through proton pump inhibitors Stefano Fais Multiple mechanisms of resistance to cisplatin in cancer cells Michael Gottsman Platinum drug damage to DNA and nucleosomes: recognition/repair and cell-response mechanisms Stephen J. Lippard Molecular rationale to improve platinum selectivity Maurizio D’Incalci Recognition and processing of platinum drugs-DNA adducts Stephen G. Chaney Platinum drugs and DNA repair: lessons from the NCI-60 panel and clinical correlates Jacques Robert Effects of platinated compounds in signal transduction: role of interaction with other drugs Godefridus J. Peters Platinum drugs as radio-sensitizer Silvia Formenti Head and Neck cancer Lisa Licitra Non-colorectal cancer Florian Lordick Colorectal cancer Andrea Bonetti New drugs for the management of chemotherapy-induced nausea and vomiting Matti Aapro Breast cancer Luca Gianni Ovarian cancer Franco Muggia Cancer of the uterus Paul Hoskins Lung cancer Giuseppe Giaccone Heavy metal compounds in cancer chemotherapy: positive findings Gianni Sava, Heavy metal compounds in cancer chemotherapy: negative findings Jan Schellens Neurotoxicity Guido Cavalletti Anemia and myelosuppression Fabio Benedetti Platinum drugs and the children with cancer Riccardo Riccardi Allergic reactions Eleni Andreopoulou Optimizing dose using patient characteristics Etienne Chatelut The real impact of intraperitoneal chemotherapy in ovarian cancer Franco Muggia IP Therapy - Where do we go from here Stephen B Howell

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