Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

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Editorial Reviews

papers from the January 1991 symposium are presented in sections on synthetic chemistry and biochemistry, biochemical and molecular pharmacology, toxicology and clinical pharmacology of new drugs, and clinical trials. Some specific topics: modelling platinum-DNA interactions; structurally novel platinum antitumor compounds; activation of a genetic program for cell death; metallothioneins and cisplatin resistance; a protein from mammalian cells that recognizes platinated DNA; and optimizing dose-intensity--combining carboplatin with cisplatin. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9781489907400
  • Publisher: Springer US
  • Publication date: 12/31/2013
  • Edition description: Softcover reprint of the original 1st ed. 1991
  • Pages: 546
  • Product dimensions: 6.10 (w) x 9.25 (h) x 1.14 (d)

Table of Contents

Synthetic Chemistry and Biochemistry: Platinum DNA Chemistry; S. Lippard. New Insights about the Interaction of Cisplatinum with Intracellular Components; J. Reedijk. Modelling Platinum-DNA Interactions; B. Lippert. From the Modelization of DNA Platination to the Conception of New Drugs; J.C. Chottard. Biochemical and Molecular Pharmacology: Role of Membrane Ion Transport in Cisplatin Accumulation; P.A. Andrews. Enhancement of the Antiproliferative Effect of Cisdiamminedichloroplatinum (II) and Other Antitumor Agents by Inhibitors of Enzymes Involved in Growth Factor SignalTransduction; H.H. Grunicke. Signal Transduction Pathway Regulation of DDP Sensitivity; S.B. Howell. The Role of Platinum-DNA Lesions in the Inhibition of DNA Replication; N.P. Johnson. Toxicology and Clinical Pharmacology of New Drugs: Pharmacokietics of Carboplatin in Children and the Development of a Pediatric Dose Equation; H. Calvert. Clinical Studies with Cisplatin Analogues, 254S, DWA2114R and NK121; H. Majima. Clinical Trials: Dose Intensity Analysis May Help Resolve Issues in Chemotherapy with Platinum Compounds; W. Hryniuk. Cisplatin DoseIntensity in Testicular Cancer Treatment: Analysis of a Randomized Clinical Trial; C.R. Nichols, et al. 39 additional articles. Index.

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