Platinum-Based Drugs in Cancer Therapy / Edition 1

by Lloyd R. Kelland, Nicholas P. Farrell

Overview

Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining their future therapeutic prospects. Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and such exciting new areas as DNA mismatch repair and replicative bypass, apoptosis, and the transport of platinum drugs into tumor cells. The emergent platinum drugs of the future-orally active agents, the sterically hindered ZD0473, and the polynuclear charged platinum BBR3464-are also fully considered. Timely and interdisciplinary, Platinum-Based Drugs in Cancer Therapy offers cancer therapeutics specialists an illuminating survey of every aspect of platinum drugs from mechanisms of action to toxicology, tumor resistance, and new analogs.

Product Details

ISBN-13:	9780896035997
Publisher:	Springer-Verlag New York, LLC
Publication date:	03/24/2000
Series:	Cancer Drug Discovery and Development
Edition description:	2000
Pages:	341
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

About the Author

Kelland, Lloyd R. (Institute of Cancer Research); Farrell, Nicholas P. (Virginia Commonwealth Univ)

Table of Contents

I: Platinum Chemistry.- 1 The Chemistry of Cisplatin in Aqueous Solution.- 2 Chemistry and Structural Biology of 1,2-Interstrand Adducts of Cisplatin.- 3 Transplatin-Modified Oligonucleotides as Potential Antitumor Drugs.- II: Platinum Biochemistry.- 4 Cisplatin Accumulation.- 5 Cisplatin Resistance in Ovarian Cancer: Mismatch Repairand Engagement of Apoptosis.- 6 DNA Adduct Tolerance and Bypass.- 7 How Does Cisplatin Kill Cells?.- III: Clinical Antitumor Activity and Toxicology of Platinum Drugs.- 8 Clinical Experience with Cisplatin and Carboplatin.- 9 Clinical Experience: Platinum and Taxanes.- 10 Clinical Experience: DACH-Based Platinum Drugs.- 11 Clinical Toxicology of Platinum-Based Cancer Chemotherapeutic Agents.- 12 Toxicology and Regulatory Aspects of Platinum Drugs.- IV: New Platinum Drugs of the Future.- 13 New Platinum Drugs: The Pathway to Oral Therapy.- 14 Polynuclear Charged Platinum Compounds as a New Class of Anticancer Agents: Toward a New Paradigm.

Editorial Reviews

This volume of the Cancer Drug Discovery and Development series provides comprehensive coverage of some of the basic science associated with cisplatin, its interaction with DNA and how recognitions and processing of platinum-DNA adducts may be associated with tumour response or resistance. ...Bringing together the most recent research in the area of platinum drugs...The editors of this book have produced a collection of articles which will be of interest to those who need an introduction to the field of platinum drugs. For anyone already familiar with the field, the chapters on the newer analogues and on some of the more recent basic molecular pharmacology issues will provide a useful update. -The Lancet

"The great attention is also paid to all toxicological aspects of platinum drugs from both clinical and regulatory perspective.... The Platinum-based Drugs in Cancer Therapy appears to be a comprehensive book useful for scientist, medical oncologist and pharmacist seeking answer on specific questions concerning preclinical and clinical data of platinum drugs."-Neoplasma

"The strength of the text lies in the diversity of topics that are covered in such a succinct fashion. Clinicians will benefit from the earlier focus on basic chemistry and biochemistry, while the bench scientist will better appreciate the practicalities of using these compounds from the lucid experiences of the clinical case studies."-Journal of Medicinal Chemistry

"This is a useful reference book for scientists and practitioners who have a focus or interest in the chemistry and biochemistry of the platinum compounds. Oncologists will find it helpful for its summary of applications of cisplatin and carboplatin, especially in combination with paclitaxel."—Oncology Journal, November, 2000

"...the book should find its place in the library of many laboratories involved mainly in preclinical oncological research."-Annals of Oncology

"This new bookby Kelland and Farrell is a well-constructed and authoritative account of current knowledge concerning the pharmacology and clinical application of platinum anticancer drugs. It is well illustrated with clear diagrams and appropriate data. ...Not only do platinum agents remain a key component of current cancer therapy for the majority of common solid tumours but recent advances have demonstrated the scope for expansion of the clinical spectrum of activity, the ability to overcome resistance, and the potential introduction of oral delivery." - Clinical Oncology

From the Publisher

Leading experts review all aspects of platinum anticancer drugs and their current use in treatment, and examine future therapeutic prospects. Writing from a variety of disciplines, they discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and new areas including DNA mismatch repair, replicative bypass, and the transport of platinum drugs into tumor cells. Antitumor activity and toxicology of platinum-based drugs is also addressed through discussion of clinical experience with cisplatin and carboplatin. Kelland is affiliated with the CRC Center for Cancer Therapeutics at the Institute of Cancer Research, UK. Farrell teaches chemistry at Virginia Commonwealth University. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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