Polycystic Kidney Disease / Edition 1

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Overview

Many inherited diseases and non-herediatry disorders have in common the development of renal cyctic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation.
Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis of polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: B. Peter E. Sawaya, MD (University of Kentucky College of Medicine)
Description: This is an extensive and comprehensive overview of polycystic kidney disease, a relatively common renal illness.
Purpose: According to the authors, this book is a state-of-the-art review of the rapidly changing knowledge of polycystic kidney disease. These objectives are very much worthy given the recent advances seen in polycystic kidney disease, particularly at the genetic and molecular biology front. The authors have met their objectives.
Audience: This book is written primarily for nephrologists and urologists. It can also be very useful to scientists and geneticists who have interest in the genetic and pathogenesis of renal cystic disease. The editors have sought the expertise of a variety of well-known scientists and clinicians to include geneticists, molecular biologists, and physiologists.
Features: This book contains an adequate number of illustrations, radiographs, figures, and tables that are pertinent to its content. References are extensive and recent. The overall appearance of the book is excellent.
Assessment: This is an excellent book. It covers extensively and comprehensively polycystic kidney disease from the laboratory bench to the bedside. More than one fourth of the book was designated to address the complex aspects of cystic genesis and the genetics of polycystic kidney disease. The editors also did not neglect to include a chapter dealing with the sensitive and very complex issue of counseling and ethical considerations in this relatively common and serious genetic disorder. This book is highly recommended for nephrologists, urologists, geneticists, and scientists who have interests in polycystic kidney disease.
B. Peter Sawaya
This is an extensive and comprehensive overview of polycystic kidney disease, a relatively common renal illness. "According to the authors, this book is a state-of-the-art review of the rapidly changing knowledge of polycystic kidney disease. These objectives are very much worthy given the recent advances seen in polycystic kidney disease, particularly at the genetic and molecular biology front. The authors have met their objectives. "This book is written primarily for nephrologists and urologists. It can also be very useful to scientists and geneticists who have interest in the genetic and pathogenesis of renal cystic disease. The editors have sought the expertise of a variety of well-known scientists and clinicians to include geneticists, molecular biologists, and physiologists. "This book contains an adequate number of illustrations, radiographs, figures, and tables that are pertinent to its content. References are extensive and recent. The overall appearance of the book is excellent. "This is an excellent book. It covers extensively and comprehensively polycystic kidney disease from the laboratory bench to the bedside. More than one fourth of the book was designated to address the complex aspects of cystic genesis and the genetics of polycystic kidney disease. The editors also did not neglect to include a chapter dealing with the sensitive and very complex issue of counseling and ethical considerations in this relatively common and serious genetic disorder. This book is highly recommended for nephrologists, urologists, geneticists, and scientists who have interests in polycystic kidney disease.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780192625786
  • Publisher: Oxford University Press, USA
  • Publication date: 7/28/1996
  • Series: Oxford Clinical Nephrology Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 608
  • Product dimensions: 8.81 (w) x 9.75 (h) x 1.49 (d)

Table of Contents

Part I: Cystic renal disease: experimental models and pathology
1. Principles of molecular biology as applied to the study of disease
2. In vitro models in the study of renal cystogenesis
3. Mouse models of polycystic kidney disease
4. In vivo models in non-murine species
5. Pathogenesis of polycystic kidney disease: basement membrane and extracellular matric
6. Pathogenesis of polycystic kidney disease: altered cellular function Part II: Cystic renal disease: clinical spectrum
7. Classification of cystic kidneys
8. Diagnostic imaging of renal cystic diseases
9. Autosomal recessive polycystic kidney disease: clinical and gentic profiles
10. Acquired renal cystic disease
11. Tuberous sclerosis
complex
12. Von Hippel-Lindau Disease Part III: Adult polycystic kidney disease: natural history and genetics
13. Definition and natural history of autosomal dominant polycystic kidney disease
14. Cloning strategies and genetics of type 1 autosomal dominant polycystic kidney disease Part IV: Adult polycystic kidney disease: clinical features
16. Hypertension in polycystic kidney disease
17. Progression to renal insufficiency
18. Management of end-stage renal failure and problems of transplantation in autosomal dominant polycystic kidney disease
19. Chronic pain and its medical and surgical management in renal cystic disease Part V: Adult polycystic kidney disease: complications
20. Miscellaneous renal and systemic complications of autosomal dominant polycystic kidney disease including infection
21. Polycystic liver disease
22. Intracranial aneurysms in autosomal dominant polycystic kidney disease
23. Particular problems in childhood and adolescents in autosomal dominant polycystic kidney disease
24. Counselling and ethical considerations in autosomal polycystic kidney disease

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