The Polycystic Ovary Syndrome: Current Concepts on Pathogenesis and Clinical Care / Edition 1

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Polycystic ovary syndrome (PCOS) is a classic female infertility problem affecting an estimated 6-10% of all women and many of whom are unaware of the problem. PCOS is the single most common endrocrinologic abnormality that affects women. It is a disease that affects women from adolescence to menopause. Patients with PCOS are seen by a variety of specialists, including: reproductive, medical and pediatric endocrinologists; general internists, and dermatologists. This book is an edited collection from diagnosis and epidemiology of PCOS to clinical evaluation. There are additional factors that complicate this disease, such as insulin levels and obesity. Women with PCOS are known to be at a high risk for type 2 diabetes.

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Editorial Reviews

Doody's Review Service
Reviewer: Janet Myra Noel, MD (Loyola University Stritch School of Medicine)
Description: This comprehensive overview of the polycystic ovary syndrome (PCOS) reviews the pathophysiology, provides updates of the most current genetic and steroidogenic advances, and offers clinical guidance in diagnosis and treatment. Because of its broad scope, it appeals to multiple disciplines.
Purpose: Although not stated, the main objectives of this book are to update readers on the most recent advances in the pathogenesis of PCOS and review clinical management. Overall, these objectives are met, but the clinical management review is limited to ovulation induction and omits the management of other aspects of PCOS, such as metabolic effects, obesity and hirsutism.
Audience: The book is written for a broad audience, particularly practitioners in endocrinology and gynecology.
Features: It begins with a good introduction that defines PCOS and then reviews the diagnosis of PCOS, before providing a current update in the genetics of PCOS. The book then explores the unique action of insulin and its interplay in the syndrome, as well as the abnormalities in PCOS at the molecular level, reviewing steroidogenic abnormalities of biosynthesis, gene expression, and signaling. It details an approach to ovulation induction and ends with a concise review of the long term morbidity associated with the disease.
Assessment: The well written chapters provide a concise, current update on recent advances in PCOS. At times, transitions between chapters are abrupt, giving the impression of separate manuscripts in a journal, but the book does cover all the major topics in PCOS. It is useful to clinicians who will be evaluating and treating patients with PCOS, particularly endocrinologists.
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Product Details

  • ISBN-13: 9780387692463
  • Publisher: Springer US
  • Publication date: 7/3/2007
  • Series: Endocrine Updates Series, #27
  • Edition description: 2007
  • Edition number: 1
  • Pages: 134
  • Product dimensions: 6.10 (w) x 9.30 (h) x 0.50 (d)

Meet the Author

Dr. Azziz is President and member of the Board of Directors of the Society of Reproductive Surgeons and a past member of the Board of Directors of the American Society for Reproductive Medicine (ASRM) and The Society of Reproductive Endocrinologists. He is also a member of the Endocrine Society and The Society for Gynecologic Investigation, among others. He serves as Executive Director of the Androgen Excess Society, of which he is also a founding member.

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Table of Contents

Definition, Diagnosis, and Epidemiology of the Polycystic Ovary Syndrome.- Clinical Evaluation of PCOS.- Genetics of PCOS.- Insulin Action in Polycystic Ovary Syndrome: In Vivo and In Vitro.- Ovarian Steroidogenic Abnormalities in PCOS.- Role of Obesity and Adiposity in PCOS.- Strategies for Ovulation Induction in the Management of Anovulatory Polycystic Ovary Syndrome.- Long-Term Morbidity of PCOS.

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