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Doody's Review ServiceReviewer: Janet Myra Noel, MD (Loyola University Stritch School of Medicine)
Description: This comprehensive overview of the polycystic ovary syndrome (PCOS) reviews the pathophysiology, provides updates of the most current genetic and steroidogenic advances, and offers clinical guidance in diagnosis and treatment. Because of its broad scope, it appeals to multiple disciplines.
Purpose: Although not stated, the main objectives of this book are to update readers on the most recent advances in the pathogenesis of PCOS and review clinical management. Overall, these objectives are met, but the clinical management review is limited to ovulation induction and omits the management of other aspects of PCOS, such as metabolic effects, obesity and hirsutism.
Audience: The book is written for a broad audience, particularly practitioners in endocrinology and gynecology.
Features: It begins with a good introduction that defines PCOS and then reviews the diagnosis of PCOS, before providing a current update in the genetics of PCOS. The book then explores the unique action of insulin and its interplay in the syndrome, as well as the abnormalities in PCOS at the molecular level, reviewing steroidogenic abnormalities of biosynthesis, gene expression, and signaling. It details an approach to ovulation induction and ends with a concise review of the long term morbidity associated with the disease.
Assessment: The well written chapters provide a concise, current update on recent advances in PCOS. At times, transitions between chapters are abrupt, giving the impression of separate manuscripts in a journal, but the book does cover all the major topics in PCOS. It is useful to clinicians who will be evaluating and treating patients with PCOS, particularly endocrinologists.