Polymorphism in Molecular Crystals 2e / Edition 2

by Joel Bernstein

Overview

Most people are familiar with the fact that diamond and graphite are both composed only of carbon; yet they have very different properties which result from the very different structures of the two solids - they are polymorphs of carbon. Understanding the relationship between the structures and the properties of materials is of fundamental importance in developing and producing new materials with improved or new properties. The existence of polymorphic systems allows the direct study of the connection between structures and properties. This book provides grounding on the fundamental structural and energetic basis for polymorphism, the preparation and characterization of polymorphic substances and its importance in the specific areas of pharmaceuticals, pigments and high energy (explosive) materials. The closing chapter describes the intellectual property implications and some of the precedent patent litigations in which polymorphism has played a central role. The book contains over 2500 references to provide a ready entry into the relevant literature.

Product Details

ISBN-13:	9780199655441
Publisher:	Oxford University Press
Publication date:	07/14/2020
Series:	International Union of Crystallography Monographs on Crystallography
Edition description:	2nd ed.
Pages:	608
Product dimensions:	9.30(w) x 6.10(h) x 1.30(d)

About the Author

Joel Bernstein, Professor Chemistry, Emeritus, Ben-Gurion University of the Negev

Joel Bernstein earned his Ph.D. in physical chemistry at Yale University for research on solid-state spectroscopy of organic compounds. Following postdoctoral stints at UCLA and the Weizmann Institute of Science, he joined the faculty of the newly established Ben-Gurion University of the Negev, where until 2010 he was the Carol and Barry Kaye Professor of Applied Science in the Chemistry Department. From 2010-2016, he was Global Distinguished Professor of Chemistry at New York University, both in Abu Dhabi and Shanghai. His research interests center on the organic solid state, with emphasis on understanding and utilizing polymorphism, structure-property relationships, hydrogen-bonding patterns and graph sets and organic conducting materials. He has published nearly 200 research and review articles and chapters on these subjects. He has served as a consultant to many multinational pharmaceutical companies and as a testifying witness in patent litigations on the solid-state chemistry of drugs.

Table of Contents

1. Introduction and historical background2. Fundamentals3. Exploring the crystal form landscape4. Analytical techniques for studying and characterizing polymorphs and polymorphic transitions5. Computational aspects of polymorphism6. Polymorphism and structure-property relations7. Polymorphism of pharmaceuticals8. Polymorphism of pigments and dyes9. Polymorphism of high energy materials10. Polymorphism and patents

Editorial Reviews

"excellent and very informative. . . Many well selected examples are discussed which guide a new researcher into the field. It is also a fantastic source of historical, fundamental and up to date papers and reviews (110 pages of references). This book then can be read by a beginner in the field but also by an active researcher in polymorphism, crystal engineering or crystal chemistry." — Claude Lecomte, Universite de Lorraine, Acta Crystallographica

From the Publisher