Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery

by Jens-Uwe Peters
     
 

View All Available Formats & Editions

An essential outline of the main facets of polypharmacology in drug discovery research

Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of

…  See more details below

Overview

An essential outline of the main facets of polypharmacology in drug discovery research

Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide:

  • Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes

  • Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles

  • Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology

  • Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology

A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.

Read More

Editorial Reviews

From the Publisher
“The book is well presented and the price is reasonable for anyone (drug designers, medicinal chemists, biochemists, biologists, clinicians and toxicologists) interested in any of the many facets that come together to make polypharmacology.”  (British Toxicology Society, 1 July 2013)

“However, anyone interested in the complex issues relating to drug promiscuity should find this very timely and topical book to be a reliable and stimulating reference that they will revisit many times.”  (ChemMedChem, 2012)

Doody's Review Service
Reviewer: Rachel R Chennault, PhD (American College of Clinical Pharmacy)
Description: This book examines the emerging polypharmacological philosophy in drug discovery research (a single compound with multiple targets), challenging the current "one-drug-one-target" approach to drug discovery. It reviews the necessary considerations during safety profiling to assess the delicate balance between promiscuous drugs' therapeutic efficacies (benefits) and adverse drug reactions, or ADRs (risks).
Purpose: Historically, researchers have sought to develop highly selective drugs in an effort to minimize ADRs due to unintended off-target effects. However, this book educates readers about the unique advantages that polypharmacological therapies have over single-target compounds, particularly in treating complex disease states, where either multiple factors contribute to pathogenicity or drug resistance arises.
Audience: This book is intended to guide drug development researchers in academic and industry sectors alike through the inherent challenges of the polypharmacological approach, with in-depth discussion of the benefits and dangers of promiscuous ligands and targets. Additionally, as the chapters of this book are authored by highly qualified experts in the pharmaceutical sciences, pharmacology students will benefit from the discussion of the fundamental concepts of polypharmacology.
Features: Organized into four distinct sections, the book begins with a discussion of the safety concerns due to off-target activities, as well as rationale for considering these activities early in the drug discovery process. The next section describes the advantages of a polypharmacological approach to drug development over a single-target philosophy by targeting networks of disease-related pathways, citing therapies for psychiatric diseases, cancer, bacterial infections, and epilepsy. The third section reviews state-of-the-art interdisciplinary approaches to promiscuous drug development that combine computational modeling with in vitro and in vivo screening assays. Finally, the last section contains various case studies with real examples of currently marketed multitargeted compounds that modulate diverse networks in the treatment of complex, polygenic diseases.
Assessment: To date, the discussion surrounding polypharmacology has been limited to a small number of journal articles and a single chapter in Drug Repositioning: Bringing New Life to Shelved Assets and Existing Drugs, Barratt and Frail Wiley-Blackwell, 2012). This book is a unique and comprehensive resource for navigating the field of promiscuous drug development and research.

Read More

Product Details

ISBN-13:
9780470590904
Publisher:
Wiley
Publication date:
03/06/2012
Pages:
544
Product dimensions:
6.20(w) x 9.20(h) x 1.60(d)

What People are saying about this

From the Publisher
“Only recently, the characterization of promiscuous ligands turned from ‘dirty drugs’ into ‘agents being rich in pharmacology.’ … Polypharmacology in Drug Discovery covers all aspects, the good, the bad and the ugly. On the one hand, a lack of specificity (the ‘bad’) causes more or less serious side effects; inhibition of certain antitargets (the ‘ugly’), e.g. the hERG channel, results in a termination of a development project, in the past even the withdrawal of already marketed drugs; on the other hand, a desired promiscuity (the ‘good’) may be beneficial, e.g. in the case of certain CNS drugs and of anti-tumor kinase inhibitors. In Peters‘ book, all these topics are discussed in great detail by internationally leading authors. Therefore, Polypharmacology in Drug Discovery is of utmost importance for all drug designers, medicinal chemists as well as biochemists and biologists. The price of the book is in excellent relationship to its 500 pages and the overall quality, in content and presentation.”—Prof. Dr. Hugo Kubinyi

Read More

Meet the Author

Jens-Uwe Peters, PhD, works in the Medicinal Chemistry Department at F. Hoffmann-La Roche. In his ten years at Roche, he has been involved in numerous drug discovery projects, has contributed to Early Safety Profiling initiatives, and has researched opportunities for polypharmacological drug discovery. Dr. Peters is author or coauthor on twenty-six journal papers and is named on twenty-two patents.

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >