Porphyric Pesticides: Chemistry, Toxicology, and Pharmaceutical Applications

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Focuses on the use of porphyrins and porphyrinogenic compounds as herbicides, insecticides, and pharmaceuticals. Discusses the synthesis, chemical structure, structure-activity relationships, and mode of action of porphyric herbicides. Examines the mammalian toxicology of porphyrins and porphyrinogenic compounds used in insecticides and therapeutic agents. Also describes the use of porphyrins and porphyrinogenic compounds as pharmaceuticals for the treatment of cancer and metabolic disorders.
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Editorial Reviews

Developed from a symposium at the 206th National Meeting of the American Chemical Society, held in Chicago, August 1993. About two- thirds of the volume discusses the use of porphyric pesticides as herbicides. Various chapters deal with the synthesis, chemical structures, quantitative structure-activity relationships, and mode of action of porphyric herbicides. The rest of the volume details the effects of porphyrins and porphyrinogenic compounds on animals. The use of porphyrins and porphyrinogenic compounds as insecticides and pharmaceuticals and their mammalian toxicology are covered. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780841229235
  • Publisher: American Chemical Society
  • Publication date: 1/28/1994
  • Series: ACS Symposium Series, #559
  • Pages: 318
  • Product dimensions: 9.10 (w) x 6.00 (h) x 0.80 (d)

Table of Contents

1 Porphyrin Biosynthesis as a Tool in Pest Management: An Overview 1
2 Synthetic Organic Chemicals That Act through the Porphyrin Pathway 18
3 Synthesis of Protoporphyrinogen Oxidase Inhibitors 34
4 [delta]-Aminolevulinic Acid Based Herbicides and Tetrapyrrole Biosynthesis Modulators 48
5 [delta]-Aminolevulinic Acid Induced Photodynamic Damage to Cucumber (Cucumis sativus L.) Plants Mediated by Singlet Oxygen 65
6 Characterization of Plant and Yeast Protoporphyrinogen Oxidase: Molecular Target of Diphenyl Ether Type Herbicides 81
7 Characterization of a Mutant of Chlamydomonas reinhardtii Resistant to Protoporphyrinogen Oxidase Inhibitors 91
8 Factors Affecting Protoporphyrin Accumulation in Plants Treated with Diphenyl Ether Herbicides 105
9 Variation in Crop Response to Protoporphyrinogen Oxidase Inhibitors 120
10 Structure-Activity Relationships of Protoporphyrinogen Oxidase Inhibiting Herbicides 133
11 Porphyrin Synthesis in Liverwort Cells Induced by Peroxidizing Herbicides 147
12 Modulators of the Porphyrin Pathway beyond Protoporphyrinogen Oxidase 161
13 Mechanisms of Plant Tolerance to Photodynamic Herbicides 177
14 Protoporphyrinogen Oxidase as the Optimal Herbicide Site in the Porphyrin Pathway 191
15 Porphyric Insecticides 206
16 Porphyrins as Chemotherapeutic Agents: Biochemistry of Protoporphyrin IX Accumulation in Mammalian Cells 233
17 Effect of Protoporphyrinogen Oxidase Inhibitors on Mammalian Porphyrin Metabolism 247
18 Photodynamic Therapy with Porphyrin Derivatives 255
19 Effects of Diphenyl Ether Herbicides on the Heme Pathway in Cultured Liver Cells 266
20 Protoporphyrinogen Oxidase Inhibitors for Tumor Therapy 280
21 Using [delta]-Aminolevulinic Acid in Cancer Therapy 291
Author Index 304
Affiliation Index 304
Subject Index 305
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