Posttranslational Modification of Proteins: Expanding Nature's Inventory / Edition 1

Posttranslational Modification of Proteins: Expanding Nature's Inventory / Edition 1

by Christopher T. Walsh
     
 

ISBN-10: 0974707732

ISBN-13: 9780974707730

Pub. Date: 10/28/2005

Publisher: Roberts and Company Publishers

The number of protein isoforms in proteomes can be two to three orders of magnitude higher than the number of genes in the genomes. This is in large part due to posttranslational modifications of proteins that provide covalent alterations to protein backbones and side chains that increase proteome complexities. Greater than 5% of the genes in the human genome

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Overview

The number of protein isoforms in proteomes can be two to three orders of magnitude higher than the number of genes in the genomes. This is in large part due to posttranslational modifications of proteins that provide covalent alterations to protein backbones and side chains that increase proteome complexities. Greater than 5% of the genes in the human genome encode enzymes that perform such modifications, including hundreds of protein kinases and opposing phosphatases, ubiquitinyl ligases, acetylases and deacetylases, methyl transferases and glycosyl transferases. The major classes of posttranslational modifications (PTM) are codified according to types of residues modified, underlying chemistry, PTM catalysts, and biological consequences. This is the first comprehensive treatment of this burgeoning area of proteome diversification.

Product Details

ISBN-13:
9780974707730
Publisher:
Roberts and Company Publishers
Publication date:
10/28/2005
Edition description:
1st Edition
Pages:
576
Product dimensions:
10.30(w) x 8.80(h) x 1.30(d)

Table of Contents

1. Introduction
2. Phosphorylation and dephosphorylation
3. Sulfurylation of proteins
4. Sulfur redox transformations in proteins
5. Protein methylation
6. Protein acetylation
7. Lipid modifications of proteins
8. Posttranslational proteolysis
9. Ubiquitin and ubiquitin like protein tags
10. Protein glycosylation
11. ADP ribosylation of proteins
12. Protein hydroxylation
13. Automodification reactions of proteins
14. Swinging arms for covalent tethering of coenzymes
15. Protein carboxyaltion and amidation
 

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